Effect of maternal asthma on fetal pulmonary artery Doppler parameters: a case-control study

Akgün Aktaş Betül; Agaoglu Zahid; Haksever Murat; Uzuner Feriha Petek; Ocal Fatma Doga; Tanacan Atakan; Sahin Dilek

doi:10.1515/jpm-2024-0123

Article

Effect of maternal asthma on fetal pulmonary artery Doppler parameters: a case-control study

Akgün Aktaş Betül , Agaoglu Zahid , Haksever Murat , Uzuner Feriha Petek , Ocal Fatma Doga , Tanacan Atakan and Sahin Dilek

Published/Copyright: May 20, 2024

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From the journal Journal of Perinatal Medicine Volume 52 Issue 6

Abstract

Objectives

To compare fetal pulmonary artery Doppler parameters between pregnant women with asthma and healthy pregnant women.

Methods

This prospective, cross-sectional study was conducted on 50 pregnant women diagnosed with asthma and 61 healthy pregnant women. Fetal pulmonary artery Doppler parameters and the fetal main pulmonary artery acceleration time/ejection time (PATET) ratio were compared between the study and control groups. Thereafter, the study group was divided into two subgroups as non-severe and severe asthma. PATET ratio was compared between the subgroups.

Results

The fetal main pulmonary artery acceleration time was 25 ms in pregnant women with asthma and 33 ms in the healthy group, indicating a statistically significant difference (p=0.001). The acceleration time/ejection time ratio was statistically lower in the asthma group (0.185 vs. 0.240, p<0.001). The acceleration time/ejection time ratio was 0.172 in patients with severe asthma and 0.195 ms in the non-severe study group (p=0.156). In the maternal asthma group, the PATET ratio of those who went to the NICU due to respiratory distress was also 0.188, and the PATET ratio of those who went to the NICU for other reasons was 0.269 (p=0.053).

Conclusions

Fetal pulmonary artery acceleration time and PATET decreased statistically in pregnant women with severe or non-severe asthma. Maternal asthma is associated with changes in pulmonary Doppler parameters in the fetus.

Keywords: maternal asthma; fetal pulmonary artery; Doppler parameters; PATET

Corresponding author: Akgün Aktaş Betül, Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Üniversiteler Mahallesi, 1604. Cadde No: 9 Çankaya, Ankara, Türkiye, Phone: +905457352990, E-mail: drbetul07@gmail.com

Acknowledgments

This study received no financial support. The authors do not have any conflicts of interest. We would like to thank all hospital staff who care for maternal and fetal health.

Research ethics: The study has been approved by the Ethics Committee No E2-22-2876 of the University of Health Sciences Ankara City Hospital.
Informed consent: Written consent was obtained from all participants.
Author contributions: B.A.A. and D.S. designed the study. A.T. analyzed the data statistics. Z.A. and M.H. collected the data. F.P.U and F.D.O created figures and performed data analysis. All authors read and approved the final manuscript.
Competing interests: The authors state not conflict of interest.
Research funding: None declared.
Data availability: Data will be made available upon reasonable request.

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Received: 2024-03-19

Accepted: 2024-05-06

Published Online: 2024-05-20

Published in Print: 2024-07-26

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Articles in the same Issue

https://doi.org/10.1515/jpm-2024-0123

Keywords for this article

maternal asthma; fetal pulmonary artery; Doppler parameters; PATET