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Mode of delivery of women with Swyer syndrome in a German case series

  • Karen Weisshaupt EMAIL logo , Wolfgang Henrich , Jörg Neymeyer and Alexander Weichert
Published/Copyright: March 17, 2021
Journal of Perinatal Medicine
From the journal Journal of Perinatal Medicine Volume 49 Issue 6

Abstract

Objectives

For women with Swyer Syndrome, a 46,XY gonadal dysgenesis, full term pregnancies are possible after oocyte donation. According to literature, mode of delivery is almost always by Caesarean section for various reasons. Medical indications are multiple pregnancies and related complications, preeclampsia, an androgynous shaped pelvis and failed induction of labor. Elective Caesarean sections were performed based on maternal request and medical recommendation.

Methods

Following careful examination and shared decision making, we planned a spontaneous delivery with a patient with Swyer syndrome and tested the different hypotheses regarding anatomical and functional features according to literature. In addition, deliveries of women with Swyer Syndrome were analyzed in a German multicenter case series.

Results

A total of seven women with Swyer syndrome with a total of 10 pregnancies were identified, who later gave birth to twelve live-born children. Seven out of 10 births were performed by elective and non-elective Caesarean section, three births took place vaginally.

Conclusions

In summary, the risk of Caesarean section delivery has increased, but spontaneous delivery can be attempted in the event of inconspicuous findings.

Keywords: oocyte donation; Swyer syndrome; XY gonadal dysgenesis
Corresponding author: Karen Weisshaupt, Department of Obstetrics, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany, Phone: +49 30 450 664139, Email:
Jörg Neymeyer and Alexander Weichert contributed equally to this work.

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Acknowledgments: We are indebted to the women who have participated in this study.

  5. Ethical approval: The study was conducted in accordance with the ethical principles found in the Declaration of Helsinki and the principles of Good Clinical Practice. The data examined in the present retrospective analysis were processed anonymously. An ethical approval was not required.

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Received: 2020-11-30
Accepted: 2021-02-16
Published Online: 2021-03-17
Published in Print: 2021-07-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Special Section: Coronavirus Disease 2019 (COVID-19) in Obstetrics
  3. Editorial
  4. COVID-19 in pregnancy: where are we now?
  5. Review
  6. Newborns at risk of Covid-19 ― lessons from the last year
  7. Opinion Paper
  8. Ethical challenges in management of critically ill pregnant patients with coronavirus disease 2019 (COVID-19)
  9. Corner of Academy
  10. Antenatal depression and anxiety during the COVID-19 pandemic: a cross-sectional study in pregnant women from routine health care contact in Greece
  11. Original Articles – Obstetrics
  12. Pregnant women’s psychological state and influence factors: anxiety, and depression during COVID-19 outbreak
  13. Anxiety and depression during pregnancy in the era of COVID-19
  14. COVID-19 vaccine hesitancy in perinatal women: a cross sectional survey
  15. Covid-19 and pregnancy: the experience of a tertiary maternity hospital
  16. Infant outcomes and maternal COVID-19 status at delivery
  17. Assessment of fetal Doppler parameters in pregnant women with COVID-19 infection: a prospective case-control study
  18. SARS-CoV-2 in pregnancy and possible transfer of immunity: assessment of peripartal maternal and neonatal antibody levels and a longitudinal follow-up
  19. Peripartal anti-SARS-CoV-2-IgA/IgG in asymptomatic pregnant women during regional SARS-CoV-2-outbreak
  20. SARS-CoV-2 in asymptomatic pregnant women in South Brazil: RT-PCR and serological detection
  21. Letter to the Editor
  22. COVID-19 vaccine: the gender disparity
  23. Regular Papers
  24. Original Articles – Obstetrics
  25. Mode of delivery of women with Swyer syndrome in a German case series
  26. Risk factors and outcomes of abnormal bleeding after external cephalic version
  27. Causal analysis of fetal death in high-risk pregnancies
  28. Original Article – Neonates
  29. Prediction of encephalopathy in perinatal asphyxia score: reaching the unreached
  30. Short Communication
  31. Deoxyribonuclease activity negative correlates with extracellular DNA in uncomplicated singleton pregnancies in the third trimester
  32. Online Only: Congress Abstracts
  33. World Congress of Perinatal Medicine
https://doi.org/10.1515/jpm-2020-0562
Keywords for this article
oocyte donation; Swyer syndrome; XY gonadal dysgenesis

Articles in the same Issue

  1. Frontmatter
  2. Special Section: Coronavirus Disease 2019 (COVID-19) in Obstetrics
  3. Editorial
  4. COVID-19 in pregnancy: where are we now?
  5. Review
  6. Newborns at risk of Covid-19 ― lessons from the last year
  7. Opinion Paper
  8. Ethical challenges in management of critically ill pregnant patients with coronavirus disease 2019 (COVID-19)
  9. Corner of Academy
  10. Antenatal depression and anxiety during the COVID-19 pandemic: a cross-sectional study in pregnant women from routine health care contact in Greece
  11. Original Articles – Obstetrics
  12. Pregnant women’s psychological state and influence factors: anxiety, and depression during COVID-19 outbreak
  13. Anxiety and depression during pregnancy in the era of COVID-19
  14. COVID-19 vaccine hesitancy in perinatal women: a cross sectional survey
  15. Covid-19 and pregnancy: the experience of a tertiary maternity hospital
  16. Infant outcomes and maternal COVID-19 status at delivery
  17. Assessment of fetal Doppler parameters in pregnant women with COVID-19 infection: a prospective case-control study
  18. SARS-CoV-2 in pregnancy and possible transfer of immunity: assessment of peripartal maternal and neonatal antibody levels and a longitudinal follow-up
  19. Peripartal anti-SARS-CoV-2-IgA/IgG in asymptomatic pregnant women during regional SARS-CoV-2-outbreak
  20. SARS-CoV-2 in asymptomatic pregnant women in South Brazil: RT-PCR and serological detection
  21. Letter to the Editor
  22. COVID-19 vaccine: the gender disparity
  23. Regular Papers
  24. Original Articles – Obstetrics
  25. Mode of delivery of women with Swyer syndrome in a German case series
  26. Risk factors and outcomes of abnormal bleeding after external cephalic version
  27. Causal analysis of fetal death in high-risk pregnancies
  28. Original Article – Neonates
  29. Prediction of encephalopathy in perinatal asphyxia score: reaching the unreached
  30. Short Communication
  31. Deoxyribonuclease activity negative correlates with extracellular DNA in uncomplicated singleton pregnancies in the third trimester
  32. Online Only: Congress Abstracts
  33. World Congress of Perinatal Medicine
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