The first-trimester serum decorin levels as a potential predictor of preeclampsia
-
Gültekin Adanaş Aydın
,
Habibe Ayvacı
Abstract
Background
Preeclampsia (PE) is a multisystem disease and is still among the leading causes of maternal and neonatal morbidity and mortality. Inadequate trophoblast invasion plays a key role in the PE pathogenesis. The proliferation, migration, and invasion of extravillous trophoblasts (EVTs) is primarily controlled by the decidua-derived transforming growth factor beta (TGF-β) and decorin. In this study, we aimed to investigate the clinical utility of serum decorin levels measured in the 11th to 14th gestational weeks to predict preeclampsia during the following weeks of gestation.
Materials and Methods
A total of 600 pregnant women, whose age and gestational age ranged from 18 to 40 years and 11 to 14 weeks, were included. Venous blood samples were obtained and stored at −80 °C. Subsequently, the patients who developed preeclampsia and healthy controls with a similar body mass index were identified and their first-trimester blood samples were analyzed for serum decorin levels.
Results
The mean serum decorin level was 8.76 ± 6.88 ng/mL for the PE group while 9.75 ± 9.82 ng/mL for the control group. No statistically significant difference was found between the two groups (p=0.838).
Conclusion
We observed that the serum decorin levels during the 11th to 14th weeks of gestation showed no predictive value for preeclampsia in pregnant women. However, more accurate conclusions about the clinical utility of decorin as a biomarker of preeclampsia would require further studies with larger samples including more patients with EOS-PE.
Research funding: Non declared.
Author contributions: Gültekin Adanaş Aydın, Gülten Özgen and Habibe Ayvacı designed the study, searched the literature, planned the concept, and prepared and edited the manuscript. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The study protocol was approved by the Ethical Review Board of the Bursa Yüksek Ihtisas Training and Research Hospital (2011-KAEK-25 2019/12-16).
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
- What is known and what remains unresolved regarding gestational diabetes mellitus (GDM)
- Corner of Academy
- Stillbirth and subsequent pregnancy outcome – a cohort from a large tertiary referral hospital
- Postmortem examination protocol and systematic re-evaluation reduce the proportion of unexplained stillbirths
- Original Articles – Obstetrics
- The first-trimester serum decorin levels as a potential predictor of preeclampsia
- Increased of the carotid intima media thickness in preeclampsia
- Maternal and neonatal outcomes among pregnant women with myasthenia gravis
- The effect of an oxytocin washout period on blood loss at cesarean delivery
- Clinical analysis of the preoperative condition and operative prognosis of post-cesarean section scar diverticulum: a case series
- Prolonged interpregnancy interval: how does it impact the length of second stage of labor?
- Furcate insertion of the umbilical cord: pathological and clinical characteristics in 132 cases
- Assisted reproductive technologies (ART) and placental abnormalities
- Pregnancy, oral health and dental education: an overview on the northeast of Italy
- Impact of an on-site perinatal mood disorders clinic in the diagnosis and management of perinatal mood disorders
- Original Articles – Newborn
- C-reactive protein as a predictor of meningitis in early onset neonatal sepsis: a single unit experience
- Short Communication
- Pharmaco-vigilance of oral MethylErgometrine prescriptions for delayed and secondary postpartum haemorrhage
Articles in the same Issue
- Frontmatter
- Review
- What is known and what remains unresolved regarding gestational diabetes mellitus (GDM)
- Corner of Academy
- Stillbirth and subsequent pregnancy outcome – a cohort from a large tertiary referral hospital
- Postmortem examination protocol and systematic re-evaluation reduce the proportion of unexplained stillbirths
- Original Articles – Obstetrics
- The first-trimester serum decorin levels as a potential predictor of preeclampsia
- Increased of the carotid intima media thickness in preeclampsia
- Maternal and neonatal outcomes among pregnant women with myasthenia gravis
- The effect of an oxytocin washout period on blood loss at cesarean delivery
- Clinical analysis of the preoperative condition and operative prognosis of post-cesarean section scar diverticulum: a case series
- Prolonged interpregnancy interval: how does it impact the length of second stage of labor?
- Furcate insertion of the umbilical cord: pathological and clinical characteristics in 132 cases
- Assisted reproductive technologies (ART) and placental abnormalities
- Pregnancy, oral health and dental education: an overview on the northeast of Italy
- Impact of an on-site perinatal mood disorders clinic in the diagnosis and management of perinatal mood disorders
- Original Articles – Newborn
- C-reactive protein as a predictor of meningitis in early onset neonatal sepsis: a single unit experience
- Short Communication
- Pharmaco-vigilance of oral MethylErgometrine prescriptions for delayed and secondary postpartum haemorrhage
