Fetal renal artery impedance in pregnancies affected by preeclampsia
-
Marwan Ma’ayeh
,
Vidhya Krishnan
Abstract
Background
Preeclampsia (PE) is a pregnancy-specific vascular endothelial disorder characterized by multi-organ system involvement. This includes the maternal kidneys, with changes such as continuous vasospasm of renal arteries and reduced renal blood flow. However, it is unclear whether similar renal vascular changes are seen in the fetus. This study sought to compare renal artery impedance in fetuses of women with and without PE.
Methods
This was a prospective Doppler assessment study of the fetal renal artery impedance in 48 singleton fetuses. The group with PE consisted of 24 appropriately grown fetuses in pregnancy complicated by both mild and severe PE and a control group of 24 uncomplicated pregnancies. Doppler studies included renal artery systolic/diastolic (S/D) ratio, pulsatility index (PI), resistance index (RI), and identification of end-diastolic blood flow.
Results
Fetuses of mothers with PE were more likely to have a lower renal artery Doppler S/D ratio (7.85 [6.4–10.2] vs. 10.8 [7.75–22.5], P = 0.03) and lower RI (0.875 [0.842–0.898] vs. 0.905 [0.872–0.957], P = 0.03). However, there was no statistically significant difference in PI. There was also no difference in the incidence of absent end-diastolic flow.
Conclusion
This study suggests that PE results in changes in blood flow to the renal arteries of the fetus. This may be associated with long-term adverse health effects later in adulthood.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Women and children first: the need for ringfencing during the COVID-19 pandemic
- Review
- The decline of amniocentesis and the increase of chorionic villus sampling in modern perinatal medicine
- Original Articles – Obstetrics
- Fetal renal artery impedance in pregnancies affected by preeclampsia
- The effect of maternal position on fetal middle cerebral artery Doppler indices and its association with adverse perinatal outcomes: a pilot study
- Interpregnancy interval and the risk for recurrence of placental mediated pregnancy complications
- Short- and long-term outcomes of preterm spontaneous twin anemia-polycythemia sequence
- How do sustained birth tears after vaginal birth affect birth tear patterns in a subsequent birth?
- Disorders of placental villous maturation in fetal death
- Atrial septal aneurysm in pregnancy: echocardiography and obstetric outcomes
- Appropriate delivery method for cardiac disease pregnancy based on noninvasive cardiac monitoring
- Original Articles – Fetus
- Success rate of five fetal cardiac views using HDlive Flow with spatiotemporal image correlation at 18–21 and 28–31 weeks of gestation
- Fetal brain development in small-for-gestational age (SGA) fetuses and normal controls
- Can fetal fractions in the cell-free DNA test predict the onset of fetal growth restriction?
- Original Articles – Newborns
- Presence of neonatal intensive care services at birth hospital and early intervention enrollment in infants ≤1500 g
- The contribution of twins conceived by in vitro fertilization to preterm birth rate: observations from a quarter of century
- Burnout in neonatal intensive care unit nurses: relationships with moral distress, adult attachment insecurities, and proneness to guilt and shame
Articles in the same Issue
- Frontmatter
- Editorial
- Women and children first: the need for ringfencing during the COVID-19 pandemic
- Review
- The decline of amniocentesis and the increase of chorionic villus sampling in modern perinatal medicine
- Original Articles – Obstetrics
- Fetal renal artery impedance in pregnancies affected by preeclampsia
- The effect of maternal position on fetal middle cerebral artery Doppler indices and its association with adverse perinatal outcomes: a pilot study
- Interpregnancy interval and the risk for recurrence of placental mediated pregnancy complications
- Short- and long-term outcomes of preterm spontaneous twin anemia-polycythemia sequence
- How do sustained birth tears after vaginal birth affect birth tear patterns in a subsequent birth?
- Disorders of placental villous maturation in fetal death
- Atrial septal aneurysm in pregnancy: echocardiography and obstetric outcomes
- Appropriate delivery method for cardiac disease pregnancy based on noninvasive cardiac monitoring
- Original Articles – Fetus
- Success rate of five fetal cardiac views using HDlive Flow with spatiotemporal image correlation at 18–21 and 28–31 weeks of gestation
- Fetal brain development in small-for-gestational age (SGA) fetuses and normal controls
- Can fetal fractions in the cell-free DNA test predict the onset of fetal growth restriction?
- Original Articles – Newborns
- Presence of neonatal intensive care services at birth hospital and early intervention enrollment in infants ≤1500 g
- The contribution of twins conceived by in vitro fertilization to preterm birth rate: observations from a quarter of century
- Burnout in neonatal intensive care unit nurses: relationships with moral distress, adult attachment insecurities, and proneness to guilt and shame
