Behcet’s disease and pregnancy: obstetrical and neonatal outcomes in a population-based cohort of 12 million births
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Seohyuk Lee
Abstract
Background
Behcet’s disease (BD) is a rare, multi-systemic inflammatory disorder for which only limited and contradictory data exists in the context of pregnancy. Our objective was to estimate the prevalence of BD in pregnancy and to evaluate maternal and fetal outcomes associated with pregnant women living with BD.
Methods
Using the 1999–2013 Healthcare Cost and Utilization Project-Nationwide Inpatient Sample from the United States, we performed a population-based retrospective cohort study consisting of pregnancies that occurred during this time period. ICD-9 codes were used to identify delivery admissions to women with or without BD. Multivariate logistic regression was used to estimate the adjusted effects of BD on maternal and fetal outcomes.
Results
Among the 12,592,676 pregnancies in our cohort, 144 were to women with BD, for an overall prevalence of 1.14 cases/100,000 births between 1999 and 2013. Over the study period, the prevalence of BD rose from 0.5 to 2.4/100,000 births. Women with BD demonstrated a two-fold greater frequency of non-delivery hospital admissions during pregnancy, and were more likely to be Caucasian, have private medical insurance, be of the upper income quartiles, and deliver at an urban teaching hospital. Women with BD were at greater risk for preterm labor and postpartum venous thromboembolism, while their newborns were more likely to be born premature.
Conclusion
BD-associated pregnancies are increasing in prevalence and are associated with a greater risk for adverse maternal and fetal outcomes in pregnancy. Appropriate thromboprophylaxis during pregnancy should be considered given the increased risk for venous thromboembolism.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Mini Review
- Skin pathologies in pregnancy
- Research Articles – Obstetrics
- Behcet’s disease and pregnancy: obstetrical and neonatal outcomes in a population-based cohort of 12 million births
- Twin anemia-polycythemia sequence and routine monitoring practices amongst maternal-fetal medicine specialists in the United States: an initial investigation
- Gestational age-related changes in shear wave speed of the uterine cervix in normal pregnancy at 12–35 weeks’ gestation
- Effects of maternal obesity, excessive gestational weight gain and fetal macrosomia on the frequency of cesarean deliveries among migrant and non-migrant women – a prospective study
- An exploratory study into social and healthcare variables of maternal mortality: a case-control study
- Research Articles – Fetus
- Fetal abdominal cysts: antenatal course and postnatal outcomes
- Reference range of fetal myocardial area by three-dimensional ultrasonography and its applicability in fetuses of pre-gestational diabetic women
- Neurological development may be accelerated in growth-restricted fetuses: a 4D ultrasound study
- Characterization of fetal monocytes in preeclampsia and fetal growth restriction
- Computerized fetal cardiotocography analysis in early preterm fetal growth restriction – a quantitative comparison of two applications
- Research Articles – Newborn
- Identification of growth patterns of preterm and small-for-gestational age children from birth to 4 years – do they catch up?
- Association of maternal disease and medication use with the risk of congenital heart defects in offspring: a case-control study using logistic regression with a random-effects model
- Continuous infusion vs. intermittent flushing of peripheral cannulas in neonates using a needleless connector: a prospective cohort study
- Mesenchymal stromal cells and TGF-β1 in tracheal aspirate of premature infants: early predictors for bronchopulmonary dysplasia?
- Erythropoietin in perinatal hypoxic-ischemic encephalopathy: a systematic review and meta-analysis
Articles in the same Issue
- Frontmatter
- Mini Review
- Skin pathologies in pregnancy
- Research Articles – Obstetrics
- Behcet’s disease and pregnancy: obstetrical and neonatal outcomes in a population-based cohort of 12 million births
- Twin anemia-polycythemia sequence and routine monitoring practices amongst maternal-fetal medicine specialists in the United States: an initial investigation
- Gestational age-related changes in shear wave speed of the uterine cervix in normal pregnancy at 12–35 weeks’ gestation
- Effects of maternal obesity, excessive gestational weight gain and fetal macrosomia on the frequency of cesarean deliveries among migrant and non-migrant women – a prospective study
- An exploratory study into social and healthcare variables of maternal mortality: a case-control study
- Research Articles – Fetus
- Fetal abdominal cysts: antenatal course and postnatal outcomes
- Reference range of fetal myocardial area by three-dimensional ultrasonography and its applicability in fetuses of pre-gestational diabetic women
- Neurological development may be accelerated in growth-restricted fetuses: a 4D ultrasound study
- Characterization of fetal monocytes in preeclampsia and fetal growth restriction
- Computerized fetal cardiotocography analysis in early preterm fetal growth restriction – a quantitative comparison of two applications
- Research Articles – Newborn
- Identification of growth patterns of preterm and small-for-gestational age children from birth to 4 years – do they catch up?
- Association of maternal disease and medication use with the risk of congenital heart defects in offspring: a case-control study using logistic regression with a random-effects model
- Continuous infusion vs. intermittent flushing of peripheral cannulas in neonates using a needleless connector: a prospective cohort study
- Mesenchymal stromal cells and TGF-β1 in tracheal aspirate of premature infants: early predictors for bronchopulmonary dysplasia?
- Erythropoietin in perinatal hypoxic-ischemic encephalopathy: a systematic review and meta-analysis
