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Maternal plasma LPCAT 1 mRNA correlates with lamellar body count

  • Robert A. Welch EMAIL logo , Maurice-Andre Recanati , Kathryn C. Welch und Michael K. Shaw
Veröffentlicht/Copyright: 19. September 2017
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 46 Heft 4

Abstract

Human lysophosphatidylcholine acyltransferase 1 (hLPCAT1) is a protein which helps produce surfactant in the fetal lung. We previously reported that levels of cell-free fetal mRNA for hLPCAT1 in amniotic fluid are correlated with lamellar body count (LBC) (r2=0.93). This short communication demonstrates that fetal hLPCAT1 mRNA is also present in maternal blood. Its quantity also correlates with amniotic fluid LBC (r2=0.81). Research in maternal plasma hLPCAT1 may assist in understanding fetal and placental maturational processes.

Keywords: Lamellar body count; LPCAT1; surfactant
Corresponding author: Robert A. Welch, MSA, MD, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Hutzel Hospital, 7 Brush North, 3900 John R., Detroit, MI 48201, USA, Tel.: +734-223-1926; Fax: +313-993-4109

  1. Author’s statement

  2. Conflict of interest: Authors state no conflict of interest.

  3. Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.

  4. Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

References

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Received: 2017-2-22
Accepted: 2017-9-2
Published Online: 2017-9-19
Published in Print: 2018-5-24

©2018 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Maternal medicine: an evolving discipline
  4. Corner of Academy
  5. Pregnancy after malignant disease – challenges and possibilities
  6. Review articles
  7. Animatio: a history of ideas on the beginning of personhood
  8. Expectant management of caesarean scar ectopic pregnancy: a systematic review
  9. Highlight articles
  10. Maternal outcomes in first and second trimester termination of pregnancy: which are the risk factors?
  11. A preliminary study of uterine scar tissue following cesarean section
  12. Catastrophic antiphospholipid syndrome (Ronald Asherson syndrome) and obstetric pathology
  13. Comparison of healthcare utilization and outcomes by gestational diabetes diagnostic criteria
  14. Adverse pregnancy outcomes and inherited thrombophilia
  15. Effect of female genital cutting performed by health care professionals on labor complications in Egyptian women: a prospective cohort study
  16. Letters to the Editor
  17. Effect of female genital cutting performed by health care professionals on labor complications in Egyptian women: methodological concerns
  18. Reply to: Effect of female genital cutting performed by health care professionals on labor complications in Egyptian women: methodological concerns
  19. Short communication
  20. Maternal plasma LPCAT 1 mRNA correlates with lamellar body count
  21. Original articles
  22. Experimental neonatal hypoxia ischemia causes long lasting changes of oxidative stress parameters in the hippocampus and the spleen
  23. Altered thymocyte and T cell development in neonatal mice with hyperoxia-induced lung injury
https://doi.org/10.1515/jpm-2017-0057
Schlagwörter für diesen Artikel
Lamellar body count; LPCAT1; surfactant

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Maternal medicine: an evolving discipline
  4. Corner of Academy
  5. Pregnancy after malignant disease – challenges and possibilities
  6. Review articles
  7. Animatio: a history of ideas on the beginning of personhood
  8. Expectant management of caesarean scar ectopic pregnancy: a systematic review
  9. Highlight articles
  10. Maternal outcomes in first and second trimester termination of pregnancy: which are the risk factors?
  11. A preliminary study of uterine scar tissue following cesarean section
  12. Catastrophic antiphospholipid syndrome (Ronald Asherson syndrome) and obstetric pathology
  13. Comparison of healthcare utilization and outcomes by gestational diabetes diagnostic criteria
  14. Adverse pregnancy outcomes and inherited thrombophilia
  15. Effect of female genital cutting performed by health care professionals on labor complications in Egyptian women: a prospective cohort study
  16. Letters to the Editor
  17. Effect of female genital cutting performed by health care professionals on labor complications in Egyptian women: methodological concerns
  18. Reply to: Effect of female genital cutting performed by health care professionals on labor complications in Egyptian women: methodological concerns
  19. Short communication
  20. Maternal plasma LPCAT 1 mRNA correlates with lamellar body count
  21. Original articles
  22. Experimental neonatal hypoxia ischemia causes long lasting changes of oxidative stress parameters in the hippocampus and the spleen
  23. Altered thymocyte and T cell development in neonatal mice with hyperoxia-induced lung injury
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