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The role of vitamin B1-B2 and plasma lipid profile in intrahepatic cholestasis of pregnancy

  • Serdar Başaranoğlu EMAIL logo , Elif Ağaçayak , Feyzullah Uçmak , Senem Yaman Tunç , Aysegül Deregözü , Zeynep Meltem Akkurt , Nurullah Peker , Mustafa Acet , Hatice Yüksel and Talip Gül
Published/Copyright: April 6, 2016

Abstract

Aim:

The present study aimed to determine the levels of total cholesterol, triglycerides (TG), low-density lipoproteins (LDL), high-density lipoproteins (HDL), and vitamins B1 and B2 in intrahepatic cholestasis of pregnancy (ICP) patients, and to evaluate if these were involved in the pathophysiology of the disease.

Methods:

The prospective randomized study included 35 pregnant patients who were admitted to the Gynecology and Obstetrics Polyclinic, Faculty of Medicine at Dicle University and who were diagnosed with ICP (Group 1), and 40 healthy pregnant women who were admitted in the same period and who had no systemic diseases that might complicate the pregnancy during the pregnancy follow-up (Group 2). Serum lipid levels and vitamins B1 and B2 were determined and compared, and statistical comparisons of the groups were made.

Results:

There was no difference between the TG levels of the two groups (P=0.631). Total cholesterol, LDL, HDL, and vitamin B1 and B2 levels were higher in Group 1 than in Group 2 (P=0.001, P=0.001, P=0.001, P=0.001, and P=0.032, respectively).

Conclusions:

Increased levels of vitamins B1 and B2 may indicate a need for increased energy metabolism at the fetus. So we believe that new studies are required, which will be supported by the placental analyses of the pyruvate and lactate levels in maternal blood at delivery and fetal cord blood in order to develop a better understanding on the fetal effects of energy metabolism.


Corresponding author: Assist. Prof. Dr. Serdar Başaranoğlu, Eski Londra Asfaltı, Hürriyet Mah., Dumlupınar Cad. No: 10 Şirinevler-Bahçelievler, Istanbul, Tel.: +90 212 901 03 60, Mobile: +90 532 789 14 58

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  1. The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2015-9-30
Accepted: 2016-2-29
Published Online: 2016-4-6
Published in Print: 2017-5-24

©2017 Walter de Gruyter GmbH, Berlin/Boston

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