Abstract
Introduction: Factor XI deficiency is predominantly found in the Ashkenazi Jewish population with a prevalence of 9%, but also seen in other ethnicities. Little information is available on obstetric anesthesia management in women with Factor XI deficiency. Therefore, we undertook a study to evaluate obstetric, anesthetic and perinatal outcomes in parturients with Factor XI deficiency.
Methods: A retrospective study was conducted with chart reviews from 1996 to 2011 resulted in 74 women with Factor XI level deficiency. We compared anesthetic and obstetric management in parturients with low (≤30%) level of Factor XI to those with higher levels.
Results: Ninety-one pregnancy outcomes were reviewed in these 74 women with Factor XI deficiency. Forty-three women had levels ≤30% in 46 labors while 31 women had levels >30% in 45 labors. Women with low levels of Factor XI were significantly more likely to receive FFP and less likely to receive neuroaxial anesthesia. There were no anesthetic complications and no difference in mode of delivery or neonatal outcomes.
Discussion: This study is the first step in building a national database for anesthetic cases and outcomes of parturients with Factor XI deficiency. Further efforts must be made to provide safe analgesia for these women.
Acknowledgments
We would like to thank Professor Stephen Halpern from the Department of anesthesiology, Sunnybrook Health Sciences Centre, and University of Toronto, Canada for his input in writing of this article.
References
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©2014 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Academy’s Corner – a new section at JPM
- Academy’s Corner
- Global education in perinatal medicine: will the bureaucracy or smartocracy prevail?
- Review articles
- Placental chorioangioma: literature review
- Sonographic measurement of cervical length as a predictor of preterm delivery: a systematic review
- Original articles – Obstetrics
- Peripartum anesthetic management of patients with Factor XI deficiency
- Risk of inferior vena cava compression syndrome during fetal MRI in the supine position – a retrospective analysis
- Fetal behavioral states are stable over daytime – evidence by longitudinal and cross-sectional fetal biomagnetic recordings
- Diet or medically treated gestational diabetes: is there any difference for obstetrical and neonatal complications? A French cohort study
- Cerebroplacental Doppler ratio and placental histopathological features in pregnancies complicated by fetal growth restriction
- Placental syndecan-1 and sulphated glycosaminoglycans are decreased in preeclampsia
- Pharmacological anti-thrombotic prophylaxis after elective caesarean delivery in thrombophilia unscreened women: should maternal age have a role in decision making?
- Values of T/QRS ratios measured during normal and post-term pregnancies
- The factors associated with the failure of transcatheter pelvic arterial embolization for intractable postpartum hemorrhage
- Hysteroscopic and laparoscopic management of uterine defects on previous cesarean delivery scars
- Chemerin concentrations in maternal and fetal compartments: implications for metabolic adaptations to normal human pregnancy
- Repetitive administration of acetylcholine receptor agonist rescues brain inflammation and brain damage after hypoxia-ischemia in newborn rat
- Original article – Fetus
- Fetal hydronephrosis: natural history and risk factors for postnatal surgery
- Original article – Newborn
- Cytomegalovirus infection among infants in California neonatal intensive care units, 2005–2010
- Letter to the Editors
- Origin of the long-term variability and acceleration of FHR studied for the prevention of cerebral palsy in fetal hypoxia and general insults
- Neonatal phototherapy, fluids, and photorelaxation
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Editorial
- Academy’s Corner – a new section at JPM
- Academy’s Corner
- Global education in perinatal medicine: will the bureaucracy or smartocracy prevail?
- Review articles
- Placental chorioangioma: literature review
- Sonographic measurement of cervical length as a predictor of preterm delivery: a systematic review
- Original articles – Obstetrics
- Peripartum anesthetic management of patients with Factor XI deficiency
- Risk of inferior vena cava compression syndrome during fetal MRI in the supine position – a retrospective analysis
- Fetal behavioral states are stable over daytime – evidence by longitudinal and cross-sectional fetal biomagnetic recordings
- Diet or medically treated gestational diabetes: is there any difference for obstetrical and neonatal complications? A French cohort study
- Cerebroplacental Doppler ratio and placental histopathological features in pregnancies complicated by fetal growth restriction
- Placental syndecan-1 and sulphated glycosaminoglycans are decreased in preeclampsia
- Pharmacological anti-thrombotic prophylaxis after elective caesarean delivery in thrombophilia unscreened women: should maternal age have a role in decision making?
- Values of T/QRS ratios measured during normal and post-term pregnancies
- The factors associated with the failure of transcatheter pelvic arterial embolization for intractable postpartum hemorrhage
- Hysteroscopic and laparoscopic management of uterine defects on previous cesarean delivery scars
- Chemerin concentrations in maternal and fetal compartments: implications for metabolic adaptations to normal human pregnancy
- Repetitive administration of acetylcholine receptor agonist rescues brain inflammation and brain damage after hypoxia-ischemia in newborn rat
- Original article – Fetus
- Fetal hydronephrosis: natural history and risk factors for postnatal surgery
- Original article – Newborn
- Cytomegalovirus infection among infants in California neonatal intensive care units, 2005–2010
- Letter to the Editors
- Origin of the long-term variability and acceleration of FHR studied for the prevention of cerebral palsy in fetal hypoxia and general insults
- Neonatal phototherapy, fluids, and photorelaxation
- Congress Calendar
- Congress Calendar