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Insulin-like growth factor-1 (IGF-1) serum concentration among 7-year-old extremely low birth weight children – an indicator of growth problems

  • Przemko Kwinta EMAIL logo , Maógorzata Klimek , Maógorzata Wójcik , Andrzej Grudzieó , Dorota Drożdż and Jacek Józef Pietrzyk
Published/Copyright: September 8, 2011
Journal of Pediatric Endocrinology and Metabolism
From the journal Volume 24 Issue 9-10

Abstract

Background: The study aim was to compare somatic development, body composition, insulin growth factor-1 (IGF-1) serum concentration and serum lipid profile between small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) 7-year-old extremely low birth weight (ELBW) children and full-term (FT) controls.

Materials and methods: Fifty-seven AGA ELBW children [mean birth weight (BW) 850 g and mean gestational age (GA) 26.4 weeks] and 24 SGA ELBW children (mean BW 833 g, mean GA 29.5 weeks) were evaluated. The control group included 37 age- and sex-matched FT children from one outpatient center.

Results: Nine AGA and four SGA were found to have short stature defined as height <3rd percentile for chronological age (p=0.9). In the AGA cohort, the results of weight, head circumference, triceps skin fold and body mass index (BMI) measurements were significantly reduced in the short-stature subgroup. IGF-1 serum concentrations differed significantly between short-stature and normal-stature subgroups (121 vs. 193 ng/mL; p=0.02). In the SGA cohort, weight and serum concentrations of total cholesterol (5.03 vs. 4.26 mmol/L; p=0.04), LDL cholesterol (3.24 vs. 2.38 mmol/L; p=0.01) and IGF-1 (113 vs. 211 ng/mL; p=0.01) differed significantly between the short-stature and normal-stature subgroups.

Conclusions: Short stature at the age of 7 years was diagnosed in a similar percentage of AGA and SGA former ELBW infants. In both cohorts short-stature children have significantly lower weight and serum IGF-1 levels. IGF-1 seems to be involved in prolonged growth restriction among ELBW infants, regardless of whether they were AGA or SGA.


Corresponding author: Przemko Kwinta, MD, PhD, Department of Pediatrics, Polish-American Children’s Hospital, Jagiellonian University, Ul. Wielicka 265, Cracow 30-663, Poland Phone: +48 126580256, Fax: +48 126584446

Received: 2011-5-1
Accepted: 2011-7-31
Published Online: 2011-09-08
Published in Print: 2011-10-01

©2011 by Walter de Gruyter Berlin Boston

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