Abstract
Epithelial solid tumors which are rare in childhood are responsible for about 9% of all childhood cancers. However, differentiated thyroid carcinomas (DTCs) are the most common of the endocrine neoplasia (0.5%–3%) in all childhood malignancies. Pediatric thyroid cancers have some clinicopathological differences from adult thyroid cancers. This analysis investigates the clinical behavior and pathological characteristics of childhood thyroid cancers, with treatment options and outcomes. A total of 26 patients who had been diagnosed as having differentiated thyroid cancer when they were younger than 18 years old, and who took radioiodine ablation treatment, were included in this analysis. The incidence of multifocality, capsule invasion and lymph node metastasis were calculated as 11.5%, 42.3% and 53.8%, respectively. At the 6th month, an absence of I-131 uptake in the neck, with a serum thyroglobulin (Tg) level <1 ng/mL in the T4 off state, was accepted as the criterion for ablation of thyroid remnant. The mean follow-up period was 20.4 months (range 6 months–5 years). As a result, 19 patients were ablated with a single dose of I-131 (2–4 GBq). A total of 6 patients took a second dose of radioiodine treatment for lymph node or distant metastases. One of these patients was 6 years old and had recently received ablation. He had diffuse lung metastasis, which was detected on the 6th day post ablation with whole body scintigraphy, and he is now under follow-up. Successful surgery and an effective radioiodine ablation have a crucial role in good outcomes of childhood DTCs.
©2011 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Editorial
- IGF-I in extremely low birth weight (ELBW): a long-term observation
- Original Articles
- A potential role for adjunctive vitamin D therapy in the management of weight gain and metabolic side effects of second-generation antipsychotics
- Intracranial hypertension in pediatric patients treated with recombinant human growth hormone: data from 25 years of the Genentech National Cooperative Growth Study
- Effects of recombinant human growth hormone on protein turnover in the fasting and fed state in adolescents with Crohn disease
- Circular IGFBP-3 level affected by the gene transfer of different growth hormone isoforms
- Changes in plasma FGF23 in growth hormone deficient children during rhGH therapy
- Insulin-like growth factor-1 (IGF-1) serum concentration among 7-year-old extremely low birth weight children – an indicator of growth problems
- The effect of the length of the prodromal period on the metabolic control within the first 2 years in children with diabetic ketoacidosis manifestation
- Clinical characteristics at presentation of type 1 diabetes mellitus in children younger than 15 years in Croatia
- Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia
- The relationship between serum magnesium levels wıth childhood obesity and insulin resistance: a review of the literature
- Fulminant type 1 diabetes mellitus in Korean adolescents
- Retinol-binding protein 4 correlates with triglycerides but not insulin resistance in prepubertal children with and without premature adrenarche
- The energy expenditure of an activity-promoting video game compared to sedentary video games and TV watching
- Acanthosis nigricans and truncal fat in overweight and obese children
- The effects of antiepileptic drugs on the relationships between leptin levels and bone turnover in prepubertal children with epilepsy
- The association between morning cortisol and adiposity in children varies by weight status
- Evaluation of two dietary treatments in obese hyperinsulinemic adolescents
- Early cardiac abnormalities and serum N-terminal pro B-type natriuretic peptide levels in obese children
- Multivariate analyses of factors that affect neonatal screening thyroid stimulating hormone
- Establishment of reference range of plasma amino acids for younger Chinese children by reverse phase HPLC
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- Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents
- Two cases of Fanconi-Bickel syndrome: first report from China with novel mutations of SLC2A2 gene
- Short Communications
- Idiopathic Fanconi’s syndrome with nephrogenic diabetes insipidus in a child who presented as vitamin D resistant rickets – a case report and review of literature
- U.S. News and World Report’s rankings of the top 50 children’s hospitals for diabetes and endocrinology reflect reputation more than objective measures
- Patient Reports
- A V59M KCNJ11 gene mutation leading to intermediate DEND syndrome in a Chinese child
- Congenital hypopituitarism presenting as dilated cardiomyopathy in a child
- Seventeen-year-old adolescent with pituitary abscess
- Blastomycosis of the central nervous system in a child: a rare cause of hypopituitarism
- A novel homozygous HESX1 mutation causes panhypopituitarism without midline defects and optic nerve anomalies
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- Congenital hypothyroidism in association with chromosome 3p25.3-pter deletion
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- Report of two unrelated patients with hereditary vitamin D resistant rickets due to the same novel mutation in the vitamin D receptor
- Vitamin D dependent rickets, diagnostic and therapeutic difficulties: two case reports
- A novel AVPR2 missense mutation in a Chinese boy with severe inherited nephrogenic diabetes insipidus
- From idiopathic diabetes insipidus to neurodegenerative Langerhans cell histiocytosis – an unusual presentation and progression of disease
- Unique concurrent appearance of two rare conditions in a young girl: central precocious puberty due to hypothalamic hamartoma and uncommon type of diabetes
- Hyperinsulinism associated with gestational exposure to bupropion in a newborn infant
- Child abuse suspicion masquerading new onset insulin dependent diabetes mellitus
- Identification of two novel BCKDHA mutations in a Chinese patient with maple syrup urine disease
- Unexpected finding of an intact distal vagina in an infant with mixed gonadal dysgenesis
- Acrogigantism and facial asymmetry: McCune-Albright syndrome
- Surgical enucleation of testicular leydigioma in a young child: case report and literature review
- A rare case of severe lactic acidosis in a preterm infant: lack of thiamine during total parenteral nutrition
- Autoimmune polyendocrinopathy associated with ring chromosome 18
- SADDAN syndrome
- Primary adrenal insufficiency in a child after busulfan and cyclophosphamide-based conditioning for hematopoietic stem cell transplantation
- Letters to the Editor
- Maple syrup urine disease in mainland China
- Evidence does not support the conclusion that soy is an endocrine disruptor
- Medical iodophobia is contagious
- Meetings
- Meetings Calendar