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Graves' Disease in a Down's Syndrome Patient

  • Mohammad Hayat Bhat , Sameena Saba , Irfan Ahmed , M. M. A. Kamili and Shaukat A. Khan
Published/Copyright: December 22, 2010
Journal of Pediatric Endocrinology and Metabolism
From the journal Volume 23 Issue 11

ABSTRACT

Thyroid dysfunction in patients with Down's syndrome is well known. Although the majority of children with Down's syndrome appear to have normal thyroid function, however, hypothyroidism is commonly seen. The presence of hyperthyroidism is rare. The etiology is believed to be autoimmune. We report a patient with Down syndrome and Graves' disease who responded well to antithyroid drugs. The rarity of this association, especially in a child younger than eight years of age, has prompted us to report this case.

KEY WORDS: Down's syndrome; Graves' disease
Corresponding author: Dr Mohammad Hayat Bhat,
Published Online: 2010-12-22
Published in Print: 2010-November

© Freund Publishing House Ltd. 2010

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  1. The Low-dose ACTH and High dose ACTH Test Biology is not Mathematics
  2. The Low-Dose ACTH Test Does Not Identify Mild Insufficiency of the Hypothalamic-Pituitary-Adrenal Axis in Children with Inadequate Stress Response
  3. Smith-Lemli-Opitz Syndrome: Autopsy with New Morphological Findings
  4. Common Skeletal Growth Retardation Disorders Resulting from Abnormalities within the Mesenchymal Stem Cells Reservoirs in the Epiphyseal Organs Pertaining to the Long Bones
  5. Disorders of Sexual Development: An Overview of 18 Years Experience in the Pediatric Endocrinology Department of Ankara University
  6. Cognitive Profile, Parental Education and BMI in Children: Reflections on Common Neuroendrocrinobiological Roots
  7. The Relationship between Abdominal Aortic Intima-Media Thickness and Lipid Profile in Neonates Born to Mothers with Preeclampsia
  8. Clinical Presentation and Autoimmune Characteristics of Very Young Children at the Onset of Type 1 Diabetes Mellitus
  9. Identification of Two Novel Chromosome Regions Associated with Isolated Growth Hormone Deficiency
  10. Pericardial Effusion in Severe Hypothyroidism in Children
  11. Effect of Gluten-Free Diet on Growth and Glycemic Control in Children with Type 1 Diabetes and Asymptomatic Celiac Disease
  12. Rathke's Cleft Cysts in Children and Adolescents: Association with Female Puberty
  13. Graves' Disease in a Down's Syndrome Patient
  14. Subcutaneous Fat Necrosis and Hypercalcemia Following Therapeutic Hypothermia – a Patient Report and Review of the Literature
  15. Patient Reports: Two Novel Frameshift Mutations in the SOX9 Gene in Two Patients with Campomelic Dysplasia who showed Long-Term Survival
  16. Leydig Cell Tumour Revealed by Bilateral Gynecomastia in a 15-Year Old Adolescent: A Patient Report
  17. 21-hydroxylase Autoantibody-negative Addison's Disease in a 5-year-old Boy with Adrenal Crisis and Type 1 Diabetes Mellitus
  18. Letter to the Editor
  19. Response to the letter by Drs. Vanden Eijnden and Martinovici
https://doi.org/10.1515/jpem.2010.185
Keywords for this article
Down's syndrome; Graves' disease

Articles in the same Issue

  1. The Low-dose ACTH and High dose ACTH Test Biology is not Mathematics
  2. The Low-Dose ACTH Test Does Not Identify Mild Insufficiency of the Hypothalamic-Pituitary-Adrenal Axis in Children with Inadequate Stress Response
  3. Smith-Lemli-Opitz Syndrome: Autopsy with New Morphological Findings
  4. Common Skeletal Growth Retardation Disorders Resulting from Abnormalities within the Mesenchymal Stem Cells Reservoirs in the Epiphyseal Organs Pertaining to the Long Bones
  5. Disorders of Sexual Development: An Overview of 18 Years Experience in the Pediatric Endocrinology Department of Ankara University
  6. Cognitive Profile, Parental Education and BMI in Children: Reflections on Common Neuroendrocrinobiological Roots
  7. The Relationship between Abdominal Aortic Intima-Media Thickness and Lipid Profile in Neonates Born to Mothers with Preeclampsia
  8. Clinical Presentation and Autoimmune Characteristics of Very Young Children at the Onset of Type 1 Diabetes Mellitus
  9. Identification of Two Novel Chromosome Regions Associated with Isolated Growth Hormone Deficiency
  10. Pericardial Effusion in Severe Hypothyroidism in Children
  11. Effect of Gluten-Free Diet on Growth and Glycemic Control in Children with Type 1 Diabetes and Asymptomatic Celiac Disease
  12. Rathke's Cleft Cysts in Children and Adolescents: Association with Female Puberty
  13. Graves' Disease in a Down's Syndrome Patient
  14. Subcutaneous Fat Necrosis and Hypercalcemia Following Therapeutic Hypothermia – a Patient Report and Review of the Literature
  15. Patient Reports: Two Novel Frameshift Mutations in the SOX9 Gene in Two Patients with Campomelic Dysplasia who showed Long-Term Survival
  16. Leydig Cell Tumour Revealed by Bilateral Gynecomastia in a 15-Year Old Adolescent: A Patient Report
  17. 21-hydroxylase Autoantibody-negative Addison's Disease in a 5-year-old Boy with Adrenal Crisis and Type 1 Diabetes Mellitus
  18. Letter to the Editor
  19. Response to the letter by Drs. Vanden Eijnden and Martinovici
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