Rathke's Cleft Cysts in Children and Adolescents: Association with Female Puberty
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Paravee Katavetin
ABSTRACT
There are few pediatric data regarding manifestations and outcomes of Rathke's cleft cysts (RCC). We retrospectively reviewed 13 cases treated at Massachusetts General Hospital over 10 years. Age at presentation was 12-17 years, except for one 7-year-old who presented with sexual precocity. There was a female preponderance [11 females, 2 males, p=0.01], and all were pubertal at diagnosis. Common features at presentation were headaches (11/13), endocrine abnormalities (5/13) and visual disturbances (2/13). Four patients underwent transsphenoidal surgery. Symptoms improved in all but one, in whom headaches persisted. Recurrent growth in one patient was treated successfully by excision. For conservatively treated patients, cyst size was unchanged over follow-up (6 months-5 years). Female preponderance and pubertal presentation suggest a possible link between sex hormones and RCC pathogenesis. Although estrogen and progesterone receptor immunostaining was negative in the cyst lining, estrogen receptor immunostaining was positive in adjacent pituitary cells. Further investigations regarding this issue are warranted.
© Freund Publishing House Ltd. 2010
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Articles in the same Issue
- The Low-dose ACTH and High dose ACTH Test Biology is not Mathematics
- The Low-Dose ACTH Test Does Not Identify Mild Insufficiency of the Hypothalamic-Pituitary-Adrenal Axis in Children with Inadequate Stress Response
- Smith-Lemli-Opitz Syndrome: Autopsy with New Morphological Findings
- Common Skeletal Growth Retardation Disorders Resulting from Abnormalities within the Mesenchymal Stem Cells Reservoirs in the Epiphyseal Organs Pertaining to the Long Bones
- Disorders of Sexual Development: An Overview of 18 Years Experience in the Pediatric Endocrinology Department of Ankara University
- Cognitive Profile, Parental Education and BMI in Children: Reflections on Common Neuroendrocrinobiological Roots
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- Identification of Two Novel Chromosome Regions Associated with Isolated Growth Hormone Deficiency
- Pericardial Effusion in Severe Hypothyroidism in Children
- Effect of Gluten-Free Diet on Growth and Glycemic Control in Children with Type 1 Diabetes and Asymptomatic Celiac Disease
- Rathke's Cleft Cysts in Children and Adolescents: Association with Female Puberty
- Graves' Disease in a Down's Syndrome Patient
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- Letter to the Editor
- Response to the letter by Drs. Vanden Eijnden and Martinovici
