Association of SUMO4 M55V Polymorphism with Type 1 Diabetes in Chinese Children
-
Yanmei Sang
ABSTRACT
Objective: A functional polymorphism at codon 55 of the small ubiquitin like modifier 4 (SUMO4) gene (methionine to valine;M55V) was recently found to be associated with type 1 diabetes mellitus mainly in Asian populations (T1D). In the present study, we aimed to investigate whether this locus also contributes to the genetic susceptiblity to type 1 diabetes in Chinese.
Research design and methods: A case-control study was performed using genomic DNA samples from 165 unrelated Chinese childhood T1D subjects and 160 normal blood donors. The SUMO4 M55V single nucleotide polymorphism (SNP) was genotyped using polymerase chain reaction (PCR) amplification followed by digestion with the restriction enzyme Mse I.
Results: The frequencies of SUMO4 163G allele were significantly increased in T1D patients (38. 2% vs healthy control subjects 28. 7%, P<0. 05, OR=1. 51, 95% CI 1. 03-2. 13). SUMO4 163 GG genotype was also significantly increased in the T1D patients (17% vs healthy control subjects 8%, P<0. 05).
Conclusions: This study indicates that the SUMO4 gene M55V variant is associated with the genetic susceptibility of T1D in Chinese children.
© Freund Publishing House Ltd.
Articles in the same Issue
- A Warning Sign from the Thyroid
- Variable Associations of Klinefelter Syndrome in Children
- Diabetes Insipidus in a Young Child
- Evaluation and Follow-up of Clinically Euthyroid Children with Normal Free T4 and Suppressed TSH
- Bicalutamide plus Anastrozole for the Treatment of Gonadotropin-Independent Precocious Puberty in Boys with Testotoxicosis: A Phase II, Open-Label Pilot Study (BATT)
- Endocannabinoid (EC) Receptor, CB1, and EC Enzymes' Expression in Primary Adipocyte Cultures of Lean and Obese Pre-pubertal Children in Relation to Adiponectin and Insulin
- The Relationship of Insulin Secretion and GAD65 Antibody Levels at Diagnosis on Glycemic Control in Type 2 Diabetes
- Morning Cortisol is Not Associated with Truncal Fatness or Resting Blood Pressure in Children: Cross-Sectional and 1-2 Year Follow-Up Analyses
- Decreased Plasma Apelin Levels in Pubertal Obese Children
- Adolescent Acromegaly: Clinical Parameters and Treatment Outcome
- Left Ventricular Diastolic Dysfunction in Adolescents with Type 1 Diabetes Reflects the Long- but Not Short- Term Metabolic Control
- Effects of a Structured Exercise Program on Insulin Resistance, Inflammatory Markers and Physical Fitness in Obese Korean Children
- Case Series of Neonatal Hypocalcemia due to Pseudohypoparathyroidism
- A Case of Antenatal Bartter Syndrome with Sensorineural Deafness
- Association of SUMO4 M55V Polymorphism with Type 1 Diabetes in Chinese Children
- Mayer-Rokintansky-Kuster-Hauser Syndrome Associated with Atrial Septal Defect, Partial Anomalous Pulmonary Venous Connection and Unilateral Kidney – An Unusual Triad of Anomalies
Articles in the same Issue
- A Warning Sign from the Thyroid
- Variable Associations of Klinefelter Syndrome in Children
- Diabetes Insipidus in a Young Child
- Evaluation and Follow-up of Clinically Euthyroid Children with Normal Free T4 and Suppressed TSH
- Bicalutamide plus Anastrozole for the Treatment of Gonadotropin-Independent Precocious Puberty in Boys with Testotoxicosis: A Phase II, Open-Label Pilot Study (BATT)
- Endocannabinoid (EC) Receptor, CB1, and EC Enzymes' Expression in Primary Adipocyte Cultures of Lean and Obese Pre-pubertal Children in Relation to Adiponectin and Insulin
- The Relationship of Insulin Secretion and GAD65 Antibody Levels at Diagnosis on Glycemic Control in Type 2 Diabetes
- Morning Cortisol is Not Associated with Truncal Fatness or Resting Blood Pressure in Children: Cross-Sectional and 1-2 Year Follow-Up Analyses
- Decreased Plasma Apelin Levels in Pubertal Obese Children
- Adolescent Acromegaly: Clinical Parameters and Treatment Outcome
- Left Ventricular Diastolic Dysfunction in Adolescents with Type 1 Diabetes Reflects the Long- but Not Short- Term Metabolic Control
- Effects of a Structured Exercise Program on Insulin Resistance, Inflammatory Markers and Physical Fitness in Obese Korean Children
- Case Series of Neonatal Hypocalcemia due to Pseudohypoparathyroidism
- A Case of Antenatal Bartter Syndrome with Sensorineural Deafness
- Association of SUMO4 M55V Polymorphism with Type 1 Diabetes in Chinese Children
- Mayer-Rokintansky-Kuster-Hauser Syndrome Associated with Atrial Septal Defect, Partial Anomalous Pulmonary Venous Connection and Unilateral Kidney – An Unusual Triad of Anomalies
