Mean Platelet Volume in Obese Adolescents with Nonalcoholic Fatty Liver Disease
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Nur Arslan
ABSTRACT
Background: Nonalcoholic fatty liver disease (NAFLD) is the accumulation of excess fat in the liver in the absence of alcohol consumption, which commonly coexists with obesity. NAFLD is associated with increased risk of atherosclerosis and insulin resistance Mean platelet volume (MPV) is a marker of platelet activation, which is a determinant of atherosclerosis.
Aims: The first aim of the present study was to investigate the MPV levels in obese adolescents and compare the MPV levels in patients with and without NAFLD and also with healthy controls. The second aim of this study was to evaluate the relationship between IR and MPV.
Patients and Methods: Case records of 128 exogenous obese adolescents were retrospectively evaluated. Laboratory parameters were collected by using a computerized patient database. Insulin resistance was calculated by a homeostasis model assessment (HOMA-IR) index. Patients were divided into two groups: patients with NAFLD (Group 1) and patients without NAFLD (Group 2). Forty-seven healthy children constituted the control group.
Results: MPV was significantly higher in obese adolescents than their healthy peers. Group 1 had significantly higher MPV than group 2. HOMA-IR was significantly higher in group 1 than group 2. MPV was significantly higher in patients with IR than patients without IR. There was a positive correlation between MPV and HOMA-IR. MPV was inversely correlated with HDL cholesterol and platelet count.
Conclusion: MPV may be used as a follow-up marker in patients with NAFLD at the point of atherosclerosis.
© Freund Publishing House Ltd. 2010
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Articles in the same Issue
- Selection of Elite Athletes, Hormones and Genes
- Association of Serum Adiponectin Levels with Artherosclerosis and the Metabolic Syndrome in Obese Children
- Septo-optic Dysplasia
- Hyperandrogenism among Elite Adolescent Female Athletes
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- GHR and VDR Genes do not Contribute to the Growth Hormone (GH) Response in GH Deficient and Turner Syndrome Patients
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- Genital Surgery for Disorders of Sex Development: Implementing a Shared Decision-Making Approach
- Mean Platelet Volume in Obese Adolescents with Nonalcoholic Fatty Liver Disease
- Congenital Hypothyroidism: Etiology
- Familial Hyperinsulinism-Hyperammonemia Syndrome in a Family with Seizures: Case Report
- Genital Sanguineous Discharge in Prepuberty: A Case of Mullerian Papilloma of Vagina in a 9 Year-Old Girl
- Glycogen Storage Disease Type III with Hypoketosis
- McCune-Albright Syndrome (MAS): Early and Extensive Bone Fibrous Dysplasia Involvement and “Mistaken Identity” Oophorectomy
- Two New Unrelated Cases of Hereditary 1,25-Dihydroxyvitamin D-resistant Rickets with Alopecia resulting from the same Novel Nonsense Mutation in the Vitamin D Receptor Gene
