Systematic Review of the Clinical Effectiveness of Genotropin (Somatropin) in Children with Short Stature
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Jane Loftus
ABSTRACT
Genotropin (somatropin) is licensed for the treatment of children with growth hormone deficiency, Prader-Willi syndrome, Turner syndrome, chronic renal insufficiency and in children born small for gestational age. This systematic review (SR) evaluated the clinical efficacy and effectiveness of Genotropin in these conditions to inform a NICE Technology Appraisal of growth hormone for the treatment of growth failure in children. Search terms were used to search seven databases, including Medline and Embase, for English language studies. Randomised controlled trials (RCTs) or observational studies investigating Genotropin in children were included. Out of 30 RCTs identified, one reported final height data. Eleven observational studies reported final height and seven were based on the Pfizer International Growth Survey (KIGS). This SR highlights the lack of long-term RCTs reporting final height data and other important qualitative outcomes, such as quality of life. Observational data, such as those from KIGS, remain vital for informing therapy.
© Freund Publishing House Ltd. 2010
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- The Diagnosis of Pediatric Cushing's Syndrome is not always simple
- Systematic Review of the Clinical Effectiveness of Genotropin (Somatropin) in Children with Short Stature
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- Cushing Disease Presenting as Arthritis
- An Unusual Presentation of Pediatric Cushing Disease: Recurrent Corticotropinoma of the Posterior Pituitary Lobe
- Cushing's Syndrome Secondary to Isolated Micronodular Adrenocotrical Disease (iMAD) associated with Rapid Onset Weight Gain and Negative Abdominal MRI Findings in a 3 year old Male
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Articles in the same Issue
- The Diagnosis of Pediatric Cushing's Syndrome is not always simple
- Systematic Review of the Clinical Effectiveness of Genotropin (Somatropin) in Children with Short Stature
- Right Atrial Thrombus in a Six- Year- Old Indian Boy with Metabolic Syndrome
- Long Term Cereal-Based Nutritional Supplementation Improved the Total Spine Bone Mineral Density amongst Sri Lankan Preschool Children: A Randomized Controlled Study
- Psychosexual Development in Children with Disorder of Sex Development (DSD) – Results from the German Clinical Evaluation Study
- Correlates of Mucosal Immunity and Upper Respiratory Tract Infections in Girls
- Subclinical Metabolic Abnormalities Associated with Obesity in Prepubertal Mexican Schoolchildren
- Refractory Rickets in Tropics
- Cushing Disease Presenting as Arthritis
- An Unusual Presentation of Pediatric Cushing Disease: Recurrent Corticotropinoma of the Posterior Pituitary Lobe
- Cushing's Syndrome Secondary to Isolated Micronodular Adrenocotrical Disease (iMAD) associated with Rapid Onset Weight Gain and Negative Abdominal MRI Findings in a 3 year old Male
- Cushing Syndrome in an Infant Due to Cortisol Secreting Adrenal Pheochromocytoma: A Rare Association
- Early Markers of Cardiovascular Dysfunction in Young Girls Affected by Cushing's Syndrome before and after Successful Cure
