Subclinical Metabolic Abnormalities Associated with Obesity in Prepubertal Mexican Schoolchildren
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Juana B. Romero
ABSTRACT
Childhood obesity has increased to epidemic levels and is considered a public health problem due to its association with a number of metabolic abnormalities, which are being detected at earlier stages of life. The objective was to evaluate the association between the presence of subclinical metabolic abnormalities (SMA) and obesity in a sample of pre–pubertal Mexican schoolchildren. Children of both sexes and 6 to 13 years old were questioned for signs of puberty, underwent anthropometric measurement and had their Body Mass Index (BMI) calculated. Two groups were formed: those with obesity (case group) and those with normal weight paired by age and chosen randomly (control group). Fasting insulin, glucose and cholesterol were measured. 92 children were included, 46 in each group, mean age 9.9 and 9.5 years old, respectively (p=0.97). A higher frequency of hyperinsulinism was found in the case group: Fasting insulin >15 mU/ml, 75% vs. 21% (case group vs. control group, respectively); fasting glucose to insulin ratio <6, 72% vs. 24%; HOMA IR >2.7, 83% vs. 14%; and decrease in QUICKI (<0.3), 80% vs. 19% (p=0.000). Hypercholesterolemia was 25% vs. 15% (p=0.22), impaired fasting glucose 28% vs. 8% (p=0.01), and family history of diabetes mellitus (DM) 35% vs. 9% (OR=5.6; 95%CI=1.5–22.2; p=0.002). In this sample of Mexican schoolchildren, obesity was associated to a higher frequency of SMA, such as hyperinsulinism and impaired fasting glucose, and to a family history of DM.
© Freund Publishing House Ltd. 2010
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Articles in the same Issue
- The Diagnosis of Pediatric Cushing's Syndrome is not always simple
- Systematic Review of the Clinical Effectiveness of Genotropin (Somatropin) in Children with Short Stature
- Right Atrial Thrombus in a Six- Year- Old Indian Boy with Metabolic Syndrome
- Long Term Cereal-Based Nutritional Supplementation Improved the Total Spine Bone Mineral Density amongst Sri Lankan Preschool Children: A Randomized Controlled Study
- Psychosexual Development in Children with Disorder of Sex Development (DSD) – Results from the German Clinical Evaluation Study
- Correlates of Mucosal Immunity and Upper Respiratory Tract Infections in Girls
- Subclinical Metabolic Abnormalities Associated with Obesity in Prepubertal Mexican Schoolchildren
- Refractory Rickets in Tropics
- Cushing Disease Presenting as Arthritis
- An Unusual Presentation of Pediatric Cushing Disease: Recurrent Corticotropinoma of the Posterior Pituitary Lobe
- Cushing's Syndrome Secondary to Isolated Micronodular Adrenocotrical Disease (iMAD) associated with Rapid Onset Weight Gain and Negative Abdominal MRI Findings in a 3 year old Male
- Cushing Syndrome in an Infant Due to Cortisol Secreting Adrenal Pheochromocytoma: A Rare Association
- Early Markers of Cardiovascular Dysfunction in Young Girls Affected by Cushing's Syndrome before and after Successful Cure
