Clinical outcomes of switching to lonapegsomatropin from somatropin for treatment of pediatric growth hormone deficiency
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Emma Coyne
,
Gajanthan Muthuvel
and
Iris Gutmark-Little
Abstract
Objectives
This study aimed to assess differences in insulin-like growth factor 1 (IGF-1) levels following the transition from somatropin to lonapegsomatropin in patients with pediatric growth hormone deficiency (GHD). Secondary objectives included the evaluation of dose titrations based on IGF-1 levels, changes in annualized height velocity (AHV) and body mass index (BMI), and assessing reported adverse effects associated with lonapegsomatropin therapy.
Methods
A single-center, retrospective review was conducted including patients diagnosed with pediatric GHD initially treated with somatropin who transitioned to lonapegsomatropin between January 1, 2022, and December 31, 2023.
Results
Fourteen patients (median age: 9 years) were included. The median somatropin dose was 0.18 mg/kg/week (range, 0.09 to 0.29) at the time of transition and patients were initiated on a median lonapegsomatropin dose of 0.23 mg/kg/week (range, 0.15 to 0.26). This resulted in an IGF-1 increase of 2.3 SDS post-switch. Dose adjustments were made based on IGF-1 levels. Five patients required immediate dose reductions; four of these required further adjustments due to persistent elevation. There were no serious adverse effects reported.
Conclusions
Lonapegsomatropin may be a favorable option to reduce injection burden for those with pediatric GHD, though the manufacturer’s recommended starting dose of 0.24 mg/kg/week may require individualization. Careful monitoring and dose adjustment based on IGF-1 levels are necessary to maintain safety and efficacy.
Acknowledgments
We would like to thank Katherine Bowers for her assistance with the statistical analysis.
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Research ethics: The local Institutional Review Board deemed the study exempt from review.
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Informed consent: Not applicable.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Conflict of interest: Authors state no conflict of interest.
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Research funding: None declared.
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Data availability: Not applicable.
References
1. Thornton, PS, Maniatis, AK, Aghajanova, E, Chertok, E, Vlachopapadopoulou, E, Lin, Z, et al.. Weekly lonapegsomatropin in treatment-naïve children with growth hormone deficiency: the phase 3 heiGHt trial. J Clin Endocrinol Metab 2021;106:3184–95. https://doi.org/10.1210/clinem/dgab529.Search in Google Scholar PubMed PubMed Central
2. Maniatis, AK, Nadgir, U, Saenger, P, Reifschneider, KL, Abuzzahab, J, Deeb, L, et al.. Switching to weekly lonapegsomatropin from daily somatropin in children with growth hormone deficiency: the fliGHt trial. Horm Res Paediatr 2022;95:233–43. https://doi.org/10.1159/000524003.Search in Google Scholar PubMed PubMed Central
3. Lin, Z, Shu, AD, Bach, M, Miller, BS, Rogol, AD. Average IGF-1 prediction for once-weekly lonapegsomatropin in children with growth hormone deficiency. J Endocr Soc 2021;6. https://doi.org/10.1210/jendso/bvab168.Search in Google Scholar PubMed PubMed Central
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Articles in the same Issue
- Frontmatter
- Original Articles
- Thyroid surgery in pediatric age: a 10-year experience at a single center and literature review
- Differentiated thyroid cancer in adolescents – does extent of disease at presentation differ with age?
- Evaluation of iodine and selenium level and thyroid functions in patients with cystic fibrosis
- Interpreting positive celiac serology in children with new-onset type 1 diabetes
- Elastographic evaluation for fatty liver disease in north Indian children and adolescents with type 1 diabetes
- Diagnostic value of fasting insulin and insulin-like growth factor-1 levels in girls with central precocious puberty
- Clinical outcomes of switching to lonapegsomatropin from somatropin for treatment of pediatric growth hormone deficiency
- Development of a disease diagnostic model to predict the occurrence of central precocious puberty of female
- Adrenal hypoandrogenism in adolescents with premature ovarian insufficiency
- The clinical presentation and genetic diagnosis of Tangier disease in the pediatric age group
- Clinical and genetic diagnosis of first cohort of differences of sexual development in the Iranian population
- Short Communication
- Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study
- Case Reports
- Coexistence of phenylketonuria and tyrosinemia type 3: challenges in the dietary management
- Acrodermatitis dysmetabolica: lessons from two pediatric cases
- Dramatic response to Evinacumab in a North Indian girl with homozygous familial hypercholesterolemia
