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Endocrine sequelae after pediatric craniopharyngioma treatment: a single-center retrospective cohort study

  • Marie Papy , Sandra Jacobs and Anne Rochtus ORCID logo EMAIL logo
Published/Copyright: October 1, 2024
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 37 Issue 11

Abstract

Objectives

Craniopharyngiomas (CP) are rare brain tumors with a low mortality rate, but with significant morbidity, in part due to the various long-term endocrine sequelae related to hypothalamic/pituitary deficiencies. Our objective was to assess the prevalence of endocrine dysfunction and outcome after treatment of CP at our institution and to apply the novel diagnostic criteria for hypothalamic syndrome (HS). In addition, we give an overview of treatments already attempted for hypothalamic obesity (HO).

Methods

This retrospective cohort study included children treated and followed up for CP at the pediatric oncology and endocrinology department at University Hospitals Leuven between January 2000 and December 2023. Clinical and endocrine characteristics were collected during a five-year period following diagnosis of CP. The Müller radiological criteria and the novel diagnostic criteria for HS were applied. A brief literature review regarding treatments already attempted for HO was conducted.

Results

Fifteen patients with pediatric CP were included in the study, all of whom developed endocrine sequelae over time. Seven patients (47 %) presented with at least one hormonal deficit, and eight patients (53 %) developed panhypopituitarism over time. HO was clinically confirmed in nine patients (60 %). 10 patients (67 %) met the diagnostic criteria for HS. Currently, no overall effective treatment strategies are available for HO.

Conclusions

Long-term endocrine sequelae and HO are highly prevalent in pediatric CP. Continuing multidisciplinary care to improve the quality of life of these patients is necessary. International cooperation and further long-term prospective trials for the treatment of HO are needed.

Keywords: pediatric craniopharyngioma; endocrine sequelae; hypothalamic obesity; hypothalamic syndrome
Corresponding author: Anne Rochtus, Department of Pediatrics, Section Pediatric Endocrinology, University Hospital Leuven, Herestraat, 49, 3000, Leuven, Belgium; and Department of Pediatrics, Section Pediatric Neurology, University Hospital Leuven, Leuven, Belgium, E-mail:

Funding source: Universitaire Ziekenhuizen Leuven, KU Leuven

Award Identifier / Grant number: KOOR

  1. Research ethics: This study protocol was reviewed and approved by Research Ethics Committee UZ/KU Leuven, approval number MP017867.

  2. Informed consent: Informed consent was obtained from all individuals included in this study.

  3. Author contributions: Marie Papy, MD and Anne Rochtus, MD PhD: conceptualization, data curation, data analysis, validation, writing, review and editing; Sandra Jacobs, MD PhD: conceptualization, validation, review and editing.

  4. Conflict of interest: Authors state no conflict of interest.

  5. Research funding: AR is supported by a post-doc research fellowship funded by University Hospitals Leuven (KOOR-UZ Leuven).

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/jpem-2024-0275).

Received: 2024-03-30
Accepted: 2024-09-11
Published Online: 2024-10-01
Published in Print: 2024-11-26

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. Selecting optimal progestational agents either alone or in combination in common pediatric endocrine settings: challenges of unmet needs
  4. Original Articles
  5. Comparison of the effectiveness of prepubertal growth hormone treatment on height and predicted adult height in children with short stature born small for gestational age vs. with a growth hormone deficiency
  6. Expanded phenotypic spectrum in MODY 5 patients with 17q12 deletion syndrome: experience from an Indian tertiary care hospital
  7. Endocrine sequelae after pediatric craniopharyngioma treatment: a single-center retrospective cohort study
  8. Premature ovarian insufficiency in pediatric cancer patients: a 10 year Rady Children’s Hospital experience
  9. Alterations in optical coherence tomography and optical coherence tomography angiography findings in children with partial biotinidase deficiency
  10. Slow growth and short stature in children with attention deficit hyperactivity disorder (ADHD): a retrospective study of 493 children who underwent growth hormone provocation testing at one tertiary paediatric endocrine centre
  11. Short Communication
  12. Assessment of diabetes-specific knowledge and its determinants among children with type 1 diabetes mellitus and their primary caregivers: Experience from a tertiary care center in North India
  13. Letters to the Editor
  14. Comment on “Diagnostic utility of the average peak LH levels measured during GnRH stimulation test”
  15. Author’s reply “Comment on diagnostic utility of the average peak LH levels measured during GnRH stimulation test”
  16. Case Reports
  17. Estrogen-insensitivity syndrome (EIS) in a female adolescent patient – a case report
  18. The complexities of managing a newborn with 6q24 transient neonatal diabetes mellitus: a case report
  19. Homozygous mutation of KISS1 receptor (KISS1R) gene identified in a Chinese patient with congenital hypogonadotropic hypogonadism (CHH): case report and literature review
  20. Selpercatinib prior to radioactive iodine for pediatric papillary thyroid carcinoma
https://doi.org/10.1515/jpem-2024-0275
Keywords for this article
pediatric craniopharyngioma; endocrine sequelae; hypothalamic obesity; hypothalamic syndrome

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. Selecting optimal progestational agents either alone or in combination in common pediatric endocrine settings: challenges of unmet needs
  4. Original Articles
  5. Comparison of the effectiveness of prepubertal growth hormone treatment on height and predicted adult height in children with short stature born small for gestational age vs. with a growth hormone deficiency
  6. Expanded phenotypic spectrum in MODY 5 patients with 17q12 deletion syndrome: experience from an Indian tertiary care hospital
  7. Endocrine sequelae after pediatric craniopharyngioma treatment: a single-center retrospective cohort study
  8. Premature ovarian insufficiency in pediatric cancer patients: a 10 year Rady Children’s Hospital experience
  9. Alterations in optical coherence tomography and optical coherence tomography angiography findings in children with partial biotinidase deficiency
  10. Slow growth and short stature in children with attention deficit hyperactivity disorder (ADHD): a retrospective study of 493 children who underwent growth hormone provocation testing at one tertiary paediatric endocrine centre
  11. Short Communication
  12. Assessment of diabetes-specific knowledge and its determinants among children with type 1 diabetes mellitus and their primary caregivers: Experience from a tertiary care center in North India
  13. Letters to the Editor
  14. Comment on “Diagnostic utility of the average peak LH levels measured during GnRH stimulation test”
  15. Author’s reply “Comment on diagnostic utility of the average peak LH levels measured during GnRH stimulation test”
  16. Case Reports
  17. Estrogen-insensitivity syndrome (EIS) in a female adolescent patient – a case report
  18. The complexities of managing a newborn with 6q24 transient neonatal diabetes mellitus: a case report
  19. Homozygous mutation of KISS1 receptor (KISS1R) gene identified in a Chinese patient with congenital hypogonadotropic hypogonadism (CHH): case report and literature review
  20. Selpercatinib prior to radioactive iodine for pediatric papillary thyroid carcinoma
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