The complexities of managing a newborn with 6q24 transient neonatal diabetes mellitus: a case report

Yannick De Silva; Stewart Birt

doi:10.1515/jpem-2024-0258

Article

The complexities of managing a newborn with 6q24 transient neonatal diabetes mellitus: a case report

Yannick De Silva and Stewart Birt

Published/Copyright: September 17, 2024

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From the journal Journal of Pediatric Endocrinology and Metabolism Volume 37 Issue 11

Abstract

Objectives

This case report delves into the intricate management of a newborn with transient neonatal diabetes mellitus (TNDM), shedding light on the complexities and challenges in treatment decisions.

Case presentation

Born prematurely with a low birth weight and a maternal background of gestational diabetes, the infant developed hyperglycaemia necessitating intravenous insulin therapy. Subsequent genetic testing confirmed 6q24-TNDM, due to the uniparental disomy of the whole of chromosome 6. Glibenclamide, a second-generation sulfonylurea, was cautiously introduced but discontinued due to adverse effects. Despite post-meal hyperglycaemia, blood glucose levels stabilised over subsequent weeks. Regular follow-ups demonstrated appropriate growth and development and the resolution of diabetes.

Conclusions

This unique case highlights the need for multidisciplinary collaboration, tailored treatment strategies, and vigilant monitoring in managing 6q24-TNDM.

Keywords: case report; glibenclamide; low birth weight; multidisciplinary collaboration; premature birth; transient neonatal diabetes mellitus

Corresponding author: Yannick De Silva, Central Coast Clinical School, The University of Newcastle, Holden Street, Gosford, 2250, Australia, E-mail: yannick.desilva@uon.edu.au

Yannick De Silva and Stewart Birt contributed equally to this work.

Acknowledgments

We would like to acknowledge Dr Tamishka De Silva and Dr Ashok Doraiswamy for their writing assistance and proof reading of the case report.

Research ethics: The local Institutional Review Board deemed the study exempt from review.
Informed consent: Informed consent was obtained from the mother of the patient included in this case report.
Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission. Y.D. and S.B. equally contributed to the conception and study design of this case report. Y.D. and S.B. were involved in the care of the patient. Y.D. drafted the manuscript; and S.B. critically revised the manuscript.
Competing interests: The authors state no conflict of interest.
Research funding: None declared.
Data availability: Not applicable.

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Received: 2024-05-29

Accepted: 2024-08-24

Published Online: 2024-09-17

Published in Print: 2024-11-26

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Articles in the same Issue

https://doi.org/10.1515/jpem-2024-0258

Keywords for this article

case report; glibenclamide; low birth weight; multidisciplinary collaboration; premature birth; transient neonatal diabetes mellitus