Does an episode of diabetic ketoacidosis affect thyroid function tests in pediatric patients?
-
Gülhan Atakul
,
Huseyin Anıl Korkmaz
,
Ahmet Gönüllü
,
Özlem Saraç Sandal
,
Özge Köprülü
,
Nilüfer Uyar
,
Utku Karaaslan
,
Hurşit Apa
,
Hasan Ağın
and
Behzat Özkan
Abstract
Objectives
The aim of our study was to investigate the changes in thyroid hormone levels during and after acute metabolic disorder in patients with diabetic ketoacidosis (DKA).
Methods
Eighty five patients diagnosed with DKA were included in the study. Patients with control thyroid function test (TFT) values at admission (the first blood sample) and 1 month later were included in the study. Thyroid function tests obtained during diabetic ketoacidosis and at the first month follow-up were compared. Euthyroidism and euthyroid sick syndrome were defined and grouped according to current guidelines. The mild and moderate groups, according to DKA classification, were combined and compared with the severe group.
Results
A significant increase was observed between the first admission and the control TFT values 1 month later. However, there was no significant difference found in TFT between mild/moderate and severe groups taken at the time of DKA. Difference between two groups, euthyroid sick syndrome and euthyroid, was examined and the result that was different from the literature was the difference between TSH levels. We found that low FT4 levels were associated with higher HgbA1c, although the correlation was weak.
Conclusions
Thyroid hormone levels may not reflect a thyroid disease during severe DKA attack. Therefore, it is unnecessary to check thyroid function tests.
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Research ethics: The study was approved by the Behcet Uz children hospital Ethics Committee (2023/112).
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Informed consent: Written informed consent was obtained from the parents of all subjects participating in the trial.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Research funding: None declared.
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Data availability: The raw data can be obtained on request from the corresponding author.
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© 2024 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
- Tackling access and payer barriers for growth hormone therapy in Saudi Arabia: a consensus statement for the Saudi Working Group for Pediatric Endocrinology
- Original Articles
- Does an episode of diabetic ketoacidosis affect thyroid function tests in pediatric patients?
- Association between proinflammatory cytokines and arterial stiffness in type 1 diabetic adolescents
- Endocrinological and metabolic profile of Gaucher disease patients treated with enzyme replacement therapy
- Diurnal 11-ketotestosterone and 17-hydroxyprogesterone saliva profiles in paediatric classical congenital adrenal hyperplasia
- Growth after pediatric kidney transplantation: a 25-year study in a pediatric kidney transplant center
- Long term clinical follow up of four patients with Wolfram syndrome and urodynamic abnormalities
- Evaluation of copeptin in children after stimulation with clonidine or L-Dopa
- Examination of quality of life and psychiatric symptoms in childhood Graves’ disease
- Timing of onset of menses after GnRH agonist treatment for central precocious puberty
- Implementation of the Mind Youth Questionnaire (MY-Q) for routine health-related quality of life screening of adolescents with type 1 diabetes in a large tertiary care center
- Case Reports
- Medulloblastoma in a child with osteoma cutis – a rare association due to loss of GNAS expression
- Ectopic lingual thyroid with subclinical hypothyroidism in children
- Pituitary stalk interruption syndrome due to novel ROBO1 mutation presenting as combined pituitary hormone deficiency and central diabetes insipidus
- A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test
Articles in the same Issue
- Frontmatter
- Review
- Tackling access and payer barriers for growth hormone therapy in Saudi Arabia: a consensus statement for the Saudi Working Group for Pediatric Endocrinology
- Original Articles
- Does an episode of diabetic ketoacidosis affect thyroid function tests in pediatric patients?
- Association between proinflammatory cytokines and arterial stiffness in type 1 diabetic adolescents
- Endocrinological and metabolic profile of Gaucher disease patients treated with enzyme replacement therapy
- Diurnal 11-ketotestosterone and 17-hydroxyprogesterone saliva profiles in paediatric classical congenital adrenal hyperplasia
- Growth after pediatric kidney transplantation: a 25-year study in a pediatric kidney transplant center
- Long term clinical follow up of four patients with Wolfram syndrome and urodynamic abnormalities
- Evaluation of copeptin in children after stimulation with clonidine or L-Dopa
- Examination of quality of life and psychiatric symptoms in childhood Graves’ disease
- Timing of onset of menses after GnRH agonist treatment for central precocious puberty
- Implementation of the Mind Youth Questionnaire (MY-Q) for routine health-related quality of life screening of adolescents with type 1 diabetes in a large tertiary care center
- Case Reports
- Medulloblastoma in a child with osteoma cutis – a rare association due to loss of GNAS expression
- Ectopic lingual thyroid with subclinical hypothyroidism in children
- Pituitary stalk interruption syndrome due to novel ROBO1 mutation presenting as combined pituitary hormone deficiency and central diabetes insipidus
- A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test
