Effects and dose-response relationship of exercise training on cardiometabolic risk factors in children with obesity

Jingxin Liu; Lin Zhu; Zekai Chen; Jing Liao; Xiaoguang Liu

doi:10.1515/jpem-2022-0395

Article

Effects and dose-response relationship of exercise training on cardiometabolic risk factors in children with obesity

Jingxin Liu , Lin Zhu , Zekai Chen , Jing Liao and Xiaoguang Liu

Published/Copyright: September 27, 2022

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From the journal Journal of Pediatric Endocrinology and Metabolism Volume 35 Issue 10

Abstract

Objectives

To explore the dose-response relationship between physical activity and the improvement of cardiometabolic risks in children with obesity, and provide a reference for the recommendation of physical activity for obese children.

Methods

A total of 96 children with obesity were recruited to participate in an exercise intervention program. An ActiGraph GT3X+ three-axis accelerometer was used to measure their physical activity. The dose groups (Q1∼Q4) were divided based on the quartiles of physical activity. The analysis of variance was used to compare the changes in body composition and cardiometabolic risk factors before and after the intervention.

Results

All intervention groups showed a significant reduction in weight, body mass index, body fat percent, fat mass, fat free mass, and skeletal muscle mass (p<0.01), and the change in the Q4 and Q3 groups was greater than in the Q2 and Q1 groups. Triglyceride, total cholesterol, low-density lipoprotein cholesterol, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were significantly reduced after intervention in all groups (p<0.01), and the change in SBP, and DBP in the Q4 group was higher than in the Q1 group (p<0.05).

Conclusions

Exercise interventions could effectively improve body composition and cardiometabolic risk factors. A higher exercise dose is associated with significant improvements in body composition, and cardiometabolic health.

Keywords: body composition; cardiometabolic risk factors; childhood obesity; dose-response; physical activity

Corresponding author: Lin Zhu, School of Sport and Health, Guangzhou Sport University, Guangzhou, P.R. China, E-mail: 40848567@qq.com

Funding source: General project of Guangdong philosophy and Social Science Foundation

Award Identifier / Grant number: GD21CTY01

Funding source: Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme

Award Identifier / Grant number: 2019

Research funding: This work was supported by the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2019), and the general project of Guangdong philosophy and Social Science Foundation (GD21CTY01).
Author contributions: Jingxin Liu designed research and performed research, Lin Zhu and Jingxin Liu wrote the manuscript, Zekai Chen, Jing Liao and Xiaoguang Liu revised the manuscript.
Competing interests: The authors declare that they have no competing interests.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The study protocol was approved by the Ethical Committee of the Guangzhou Sport University (No. 2018LCLL-008).

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Received: 2022-08-08

Accepted: 2022-08-29

Published Online: 2022-09-27

Published in Print: 2022-10-26

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Articles in the same Issue

https://doi.org/10.1515/jpem-2022-0395

Keywords for this article

body composition; cardiometabolic risk factors; childhood obesity; dose-response; physical activity