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Three pediatric cases of symptomatic hyponatremia in Prader–Willi syndrome

  • Yuji Oto EMAIL logo , Nobuyuki Murakami , Ryo Nakagawa , Masatsune Itoh , Toshiro Nagai and Tomoyo Matsubara
Published/Copyright: July 12, 2022
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 35 Issue 10

Abstract

Objectives

A recent large retrospective cohort study of cases of hyponatremia in Prader–Willi syndrome (PWS), conducted at nine reference centers, showed that severe hyponatremia was rare in PWS (0.5%); furthermore, all cases involved adults. Here, we describe three pediatric cases of severe hyponatremia in PWS, with neurological symptoms.

Case presentation

The cases involved two girls and one boy, and only one patient showed uniparental disomy. All patients had hyponatremia during infancy and presented with clinical symptoms, such as convulsions. All three patients improved with intravenous fluids and fluid restriction, with no sequelae.

Conclusions

We report three pediatric cases of symptomatic hyponatremia of unknown cause in PWS. In patients with PWS, especially those with neurological symptoms such as convulsions, it is necessary to take hyponatremia into consideration.

Keywords: children; hyponatremia; Prader–Willi syndrome
Corresponding author: Yuji Oto, Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya City, 343-8555, Saitama, Japan, Phone: +81-48-965-1111, Fax: +81-48-965-8363, E-mail:

Acknowledgments

We are grateful to the patients and their families for their consent.

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: This study was approved by the Ethics Board of the Dokkyo Medical University Saitama Medical Center (Approval no.21108) and was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all parents.

  5. Ethical approval: The local Institutional Review Board deemed the study exempt from review.

References

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Received: 2022-03-11
Accepted: 2022-06-20
Published Online: 2022-07-12
Published in Print: 2022-10-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jpem-2022-0127
Keywords for this article
children; hyponatremia; Prader–Willi syndrome

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Newborn screening for propionic, methylmalonic acidemia and vitamin B12 deficiency. Analysis of 588,793 newborns
  4. Use of letrozole to augment height outcome in pubertal boys: a retrospective chart review
  5. Study of the frequency and clinical features of maturity-onset diabetes in the young in the pediatric and adolescent diabetes population in Iran
  6. Iatrogenic hyperthyroidism in primary congenital hypothyroidism: prevalence and predictive factors
  7. Utility of head CT scan in treatment decisions for suspected cerebral edema in children with DKA
  8. Newborn screening and genetic variation of medium chain acyl-CoA dehydrogenase deficiency in the Chinese population
  9. Performance of glucagon stimulation test in diagnosing central adrenal insufficiency in children when utilising the Roche Elecsys® cortisol II assay: a pilot study
  10. Effects and dose-response relationship of exercise training on cardiometabolic risk factors in children with obesity
  11. Biochemical indicators of euthyroid sick syndrome in critically ill children
  12. Short Communication
  13. Parental marital relationship satisfaction predicts glycemic outcomes in children with type 1 diabetes
  14. Case Reports
  15. Late onset Bartter syndrome: Bartter syndrome type 2 presenting with isolated nephrocalcinosis and high parathyroid hormone levels mimicking primary hyperparathyroidism
  16. Three pediatric cases of symptomatic hyponatremia in Prader–Willi syndrome
  17. Identification of a novel mutation in FGFR1 gene in mother and daughter with Kallmann syndrome
  18. Exaggerated mini-puberty in a preterm girl: a case report and review of literature
  19. Diabetic ketoacidosis masquerading behind alkalemia an undiagnosed or missed variant of diabetic ketoacidosis
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