Home Effects of vitamin D supplementation on glycemic control of children and adolescents with type 1 diabetes mellitus: a systematic review
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Effects of vitamin D supplementation on glycemic control of children and adolescents with type 1 diabetes mellitus: a systematic review

  • Bárbara Folino Nascimento , Carolina F.F. Moreira , Eliana R. da Fonseca , Pamela M.K. Fedeszen , Tatiana P. de Paula , Ana Silvia S. de Sena , Nathália F.A. de Almeida , Orlando C. de S. Bandeira Filho , Daniella R. Curval and Patricia de C. Padilha EMAIL logo
Published/Copyright: July 18, 2022
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 35 Issue 8

Abstract

Objectives

To evaluate the effect of vitamin D supplementation on glycemic control in children and adolescents with T1DM.

Content

A systematic search was conducted of the Medline/PubMed, Web of Science, Embase, BVS/Lilacs, Cochrane Library, Scopus, Cinahl, Food Science, and FSTA databases. Two reviewers independently extracted article data and assessed quality.

Summary

A total of 1,613 eligible articles were retrieved, ten of which met the selection criteria: eight clinical trials, one retrospective cohort study, and one cross-sectional study. Regarding the cutoff points used to classify vitamin D status, most of the studies set deficiency at 25-hydroxyvitamin D <20 ng/mL, sufficiency at ≥30 ng/mL, and insufficiency as the interval between these values. Regarding intervention strategies, most used cholecalciferol for supplementation, but there was great variation in the dose and supplementation time. When evaluating the effect of vitamin D supplementation on HbA1c, a significant improvement in glycemic control was observed in 50% of the studies. However, only one of these studies was classified as being of positive methodological quality, with three having their quality classified as neutral and one as negative.

Outlook

There is yet no consistent evidence on the effect of vitamin D supplementation on glycemic control as an adjuvant in the treatment of children and adolescents with T1DM.

Keywords: adolescents; children; glycemic control; type 1 diabetes mellitus; vitamin D
Corresponding author: Patricia de C. Padilha, Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, bl. J, 2o. andar, Rio de Janeiro, Brazil; and Instituto de Puericultura e Pediatria Martagão Gesteira (IPPMG), Federal University of Rio de Janeiro, Rio de Janeiro, 21941-590, Brazil, Phone: +55 21 3938 6599, E-mail:

Funding source: Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Award Identifier / Grant number: Proc. 250357

Acknowledgments

PCP would like to thank National Council for Technological and Scientific Development (CNPq) for their research productivity fellowships. Fundação de Amparo a Pesquisa do Rio de Janeiro (FAPERJ) bygrant “Apoio a GruposEmergentes de Pesquisa no Estado do Rio de Janeiro” – 2019 (Proc. 250357).

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpem-2022-0044).

Received: 2022-01-25
Accepted: 2022-06-20
Published Online: 2022-07-18
Published in Print: 2022-08-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Review Article
  3. Effects of vitamin D supplementation on glycemic control of children and adolescents with type 1 diabetes mellitus: a systematic review
  4. Original Articles
  5. A preliminary study on the relationship between environmental endocrine disruptors and precocious puberty in girls
  6. Tissue concentration of aldosterone in fetal adrenals of intrauterine death cases
  7. Complications of orthopedic treatment in patients diagnosed with X-linked hypophosphatemic rickets
  8. Comparison of insulin sensitivity indices for detection of double diabetes in Indian adolescents with type 1 diabetes
  9. Evaluation of the growth and nutritional status of preschool children: a pilot study in the cold area of China
  10. Arterial hypertension is associated with an increased risk of metabolic complications in pediatric patient with obesity
  11. From pregnancy to breastfeeding: adequate maternal body mass index is essential to prevent a high body mass index in your children
  12. Screening of non-syndromic early-onset child and adolescent obese patients in terms of LEP, LEPR, MC4R and POMC gene variants by next-generation sequencing
  13. The association between vitamin B12, folate, homocysteine levels, and carotid intima-media thickness in children with obesity: a cross-sectional study
  14. Comprehensive assessment of cardiovascular disease risk in children with short stature due to isolated growth hormone deficiency: a case-control study
  15. Visceral adiposity is related to insulin sensitivity and inflammation in adolescents with obesity and mild sleep disordered breathing
  16. Recurrent hypoglycemic seizure as a presenting symptom of post-TBI hypopituitarism in children: a case report, review and proposed protocol
  17. Evaluation of the etiological and clinical characteristics of pediatric central diabetes insipidus
  18. Case Reports
  19. Clinical and radiologic evaluation of a Turkish family with hypochondroplasia and a rare FGFR3 variant
  20. Rituximab therapy in ROHHAD(NET) syndrome
  21. Ectopic parathyroid hormone as a rare aetiology of hypercalcemia with rhabdomyosarcoma: a new treatment strategy with zoledronic acid and Denosumab
  22. A 2-bp deletion mutation in SMPD1 gene leading to lysosomal acid sphingomyelinase deficiency in a Chinese consanguineous pedigree
https://doi.org/10.1515/jpem-2022-0044
Keywords for this article
adolescents; children; glycemic control; type 1 diabetes mellitus; vitamin D

Articles in the same Issue

  1. Frontmatter
  2. Review Article
  3. Effects of vitamin D supplementation on glycemic control of children and adolescents with type 1 diabetes mellitus: a systematic review
  4. Original Articles
  5. A preliminary study on the relationship between environmental endocrine disruptors and precocious puberty in girls
  6. Tissue concentration of aldosterone in fetal adrenals of intrauterine death cases
  7. Complications of orthopedic treatment in patients diagnosed with X-linked hypophosphatemic rickets
  8. Comparison of insulin sensitivity indices for detection of double diabetes in Indian adolescents with type 1 diabetes
  9. Evaluation of the growth and nutritional status of preschool children: a pilot study in the cold area of China
  10. Arterial hypertension is associated with an increased risk of metabolic complications in pediatric patient with obesity
  11. From pregnancy to breastfeeding: adequate maternal body mass index is essential to prevent a high body mass index in your children
  12. Screening of non-syndromic early-onset child and adolescent obese patients in terms of LEP, LEPR, MC4R and POMC gene variants by next-generation sequencing
  13. The association between vitamin B12, folate, homocysteine levels, and carotid intima-media thickness in children with obesity: a cross-sectional study
  14. Comprehensive assessment of cardiovascular disease risk in children with short stature due to isolated growth hormone deficiency: a case-control study
  15. Visceral adiposity is related to insulin sensitivity and inflammation in adolescents with obesity and mild sleep disordered breathing
  16. Recurrent hypoglycemic seizure as a presenting symptom of post-TBI hypopituitarism in children: a case report, review and proposed protocol
  17. Evaluation of the etiological and clinical characteristics of pediatric central diabetes insipidus
  18. Case Reports
  19. Clinical and radiologic evaluation of a Turkish family with hypochondroplasia and a rare FGFR3 variant
  20. Rituximab therapy in ROHHAD(NET) syndrome
  21. Ectopic parathyroid hormone as a rare aetiology of hypercalcemia with rhabdomyosarcoma: a new treatment strategy with zoledronic acid and Denosumab
  22. A 2-bp deletion mutation in SMPD1 gene leading to lysosomal acid sphingomyelinase deficiency in a Chinese consanguineous pedigree
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