The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty
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Enver Atay
Abstract
Background
There is no data regarding the interrelationships of circulating Makorin Ring Finger Protein-3 (MKRN3), Kisspeptin (KISS1), and Neurokinin B (NKB) concentrations during minipuberty in humans.
Objective
To determine temporal changes in circulating concentrations of MKRN3, KISS1, NKB, and gonadotropins and investigate interrelationships between them in healthy full-term (FT) and preterm (PT) infants during minipuberty period.
Methods
A prospective study of 6-month follow-up performed. Eighty-seven healthy newborns, 48 FT (19 boys/29 girls), and 39 PT (21 boys/18 girls) (gestational age 31–37 weeks), were included. Blood samples were taken at 7 days (D7), 2 months (M2), and 6 months (M6) of age. Serum MKRN3, KISS1, NKB, LH, FSH, total testosterone (TT), and estradiol (E2) concentrations were measured.
Results
Seventy infants completed the study. MKRN3, KISS1, and NKB concentrations were similar in FT girls and boys. PT boys and girls also had similar concentrations of MKRN3, KISS1, and NKB. FT babies had significantly higher NKB concentrations than PT babies at D7, M2, and M6. MKRN3 and KISS1 concentrations do not differ between FT and PT babies. A strong positive correlation was found between MKRN3 and KISS1 at each time point and in all groups. FSH, LH, TT/E2 concentrations decrease while those of MKRN3 and KISS1 have a trend to increase toward the end of minipuberty. No correlation was detected between gonadotropins and MKRN3, KISS1, NKB concentrations.
Conclusion
Strong positive correlation demonstrated between KISS1 and MKRN3 suggests that interrelationship between molecules controlling minipuberty is not similar to those at puberty.
Research funding: The project is funded by Istanbul Medipol University Scientific Research Support program.
Author contributions: E. Atay, S. Kılınç, and Z. Atay designed and directed the project. E. Atay, S. Kılınç, and Z. Atay took the lead in preparing the draft article with medical writing assistance. All other authors contributed to data collection, participated in data analysis and interpretation, and critically reviewed the draft article.
Competing interests: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this review.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The present investigation was conducted in accordance with the Declaration of Helsinki for human studies and was approved by the Swedish Ethical Review Authority (Dnr 2019-05076).
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review Article
- Inborn errors of immunity and metabolic disorders: current understanding, diagnosis, and treatment approaches
- Original Articles
- Evaluation of hydration status of children with obesity—a pilot study
- Relationship between insulin-like growth factor-1, insulin resistance and metabolic profile with pre-obesity and obesity in children
- Evaluation of Hemoglobin A1c before and after initiation of continuous glucose monitoring in children with type 1 diabetes mellitus
- Karyotype is associated with timing of ovarian failure in women with Turner syndrome
- The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty
- Brain MRIs may be of low value in most children diagnosed with isolated growth hormone deficiency
- Significant improvement in bone mineral density in pediatric celiac disease: even at six months with gluten-free diet
- Population-based waist circumference reference values in Japanese children (0–6 years): comparisons with Dutch, Swedish and Turkish preschool children
- Extended growth charts for Indian children
- Rib fractures in infancy, case-series and register case-control study from Sweden
- Gonadotropin releasing hormone analogue therapy in girls with idiopathic precocious puberty/early-fast puberty: dynamics in adiposity indices, eating habits and quality of life
- Case Reports
- Transient benign hyperphosphatasemia due to COVID-19: the first case report
- ATP synthase deficiency due to m.8528T>C mutation – a novel cause of severe neonatal hyperammonemia requiring hemodialysis
- IgG4-related hypophysitis in adolescence
- Graves’ disease in a five-month-old boy with an unusual treatment course
- Oral sodium phenylbutyrate for hyperammonemia associated with congenital portosystemic shunt: a case report
- Severe multisystem organ dysfunction in an adolescent with simultaneous presentation of Addison’s and Graves’ disease
Articles in the same Issue
- Frontmatter
- Review Article
- Inborn errors of immunity and metabolic disorders: current understanding, diagnosis, and treatment approaches
- Original Articles
- Evaluation of hydration status of children with obesity—a pilot study
- Relationship between insulin-like growth factor-1, insulin resistance and metabolic profile with pre-obesity and obesity in children
- Evaluation of Hemoglobin A1c before and after initiation of continuous glucose monitoring in children with type 1 diabetes mellitus
- Karyotype is associated with timing of ovarian failure in women with Turner syndrome
- The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty
- Brain MRIs may be of low value in most children diagnosed with isolated growth hormone deficiency
- Significant improvement in bone mineral density in pediatric celiac disease: even at six months with gluten-free diet
- Population-based waist circumference reference values in Japanese children (0–6 years): comparisons with Dutch, Swedish and Turkish preschool children
- Extended growth charts for Indian children
- Rib fractures in infancy, case-series and register case-control study from Sweden
- Gonadotropin releasing hormone analogue therapy in girls with idiopathic precocious puberty/early-fast puberty: dynamics in adiposity indices, eating habits and quality of life
- Case Reports
- Transient benign hyperphosphatasemia due to COVID-19: the first case report
- ATP synthase deficiency due to m.8528T>C mutation – a novel cause of severe neonatal hyperammonemia requiring hemodialysis
- IgG4-related hypophysitis in adolescence
- Graves’ disease in a five-month-old boy with an unusual treatment course
- Oral sodium phenylbutyrate for hyperammonemia associated with congenital portosystemic shunt: a case report
- Severe multisystem organ dysfunction in an adolescent with simultaneous presentation of Addison’s and Graves’ disease
