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Vitamin D status is related to severity at onset of diabetes and worse glycemic control

  • Raquel Segovia-Ortí ORCID logo EMAIL logo , Antonia Barceló Bennassar , Diego de Sotto-Esteban and Pilar Sanchís Cortés
Published/Copyright: August 27, 2020
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 33 Issue 10

Abstract

Objectives

Our aim is to evaluate whether 25-hydroxyvitamin D at onset of type 1 diabetes mellitus (T1DM) would influence analytical variables of worse prognosis of the disease at the beginning and after one year of development.

Methods

A retrospective study of pediatric patients (0–14 years) diagnosed with T1DM with initial measurements of 25-hydroxyvitamin D was performed at Son Espases Hospital, between March 2012 and April 2019 (n=67).

Results

Vitamin D insufficiency was related to age, glycosylated hemoglobin, and creatinine. An improvement in glycosylated hemoglobin was found in subjects whose baseline serum 25(OH)D was >30 ng/mL. Bivariate correlation analysis adjusted by age showed a significantly positive correlation of vitamin D with pH (r=0.279), bicarbonate (r=0.338), and free levothyroxine (r=0.293). Independent variables associated with vitamin D insufficiency were age (odds ratio [OR]=1.2) and winter season (OR=10.52).

Conclusion

Hypovitaminosis D is related to biochemical variables showing greater severity and higher glycosylated hemoglobin at diagnosis: higher creatinine, lower free levothyroxine, pH, and bicarbonate. Unsupplemented patients with baseline deficiency showed persistently worse glycemic control vs. those with baseline repletion.

Keywords: diabetes in children and adolescents; diabetes mellitus type 1; diabetic onset; vitamin D insufficiency; vitamin D
Corresponding author: Raquel Segovia Ortí, Pediatrics, Son Espases University Hospital, Valldemossa Street 79, Palma, CP 07120, Majorca, Spain, Phone: 0034 606756666, E-mail:

Acknowledgment

The authors would like to thank Children’s Endocrinology Service of Son Espases Hospital for their outstanding collaboration for the data collection.

  1. Research funding: There is no funding source.

  2. Author Contributions: R.S.O. researched data and wrote the manuscript. D.S.E. and A.B.B. contributed to the discussion and reviewed. P.S.C. performed the statistical analysis. R.S.O. is guarantor of this work and had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

  3. Competing interests: The authors have no conflicts of interest to declare.

  4. Informed consent: Informed consent was not obtained from all individual participants included in the study because its retrospective observational design, where no personal data are collected, with minimal or no risk for the subjects, properly anonymize.

  5. Ethical approval: The study was approved by the Balearic Islands Research Ethics Committee (reference number: IB 3882/19 PI). Research was conducted ethically in accordance with the World Medical Association Declaration of Helsinki.

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Received: 2020-03-31
Accepted: 2020-06-04
Published Online: 2020-08-27

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

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  2. Research Articles
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  4. Cascade screening and treatment of children with familial hypercholesterolemia in Turkey
  5. Risk of adrenal insufficiency following intra-articular or periarticular corticosteroid injections among children with chronic arthritis
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  7. Reassessing vitamin D supplementation in preterm infants: a prospective study and review of the literature
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  14. Glycogen storage disease type VI can progress to cirrhosis: ten Chinese patients with GSD VI and a literature review
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  17. Case Reports
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  19. Carbonic anhydrase VA deficiency: a very rare case of hyperammonemic encephalopathy
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https://doi.org/10.1515/jpem-2020-0149
Keywords for this article
diabetes in children and adolescents; diabetes mellitus type 1; diabetic onset; vitamin D insufficiency; vitamin D

Articles in the same Issue

  1. Frontmatter
  2. Research Articles
  3. Analysis of the alpha galactosidase gene: mutation profile and description of two novel mutations with extensive literature review in Turkish population
  4. Cascade screening and treatment of children with familial hypercholesterolemia in Turkey
  5. Risk of adrenal insufficiency following intra-articular or periarticular corticosteroid injections among children with chronic arthritis
  6. Vitamin D status is related to severity at onset of diabetes and worse glycemic control
  7. Reassessing vitamin D supplementation in preterm infants: a prospective study and review of the literature
  8. Mutations in PMM2 gene in four unrelated Spanish families with polycystic kidney disease and hyperinsulinemic hypoglycemia
  9. Liraglutide pharmacokinetics and exposure-response in pediatric patients with type 2 diabetes
  10. Identification of nucleotide polymorphism within the NeuroD1 candidate gene and its association with type 1 diabetes susceptibility in Iranian people by polymerase chain reaction-restriction fragment length polymorphism
  11. Prevalence of autoantibodies in type 1 diabetes mellitus pediatrics in Mazandaran, North of Iran
  12. Clinical features of the diabetes eating problem survey–revised Turkish version in children and adolescent with type 1 diabetes
  13. Ambulatory blood pressure profile in office normotensive obese children: prevalence of masked hypertension and impact of parental hypertension
  14. Glycogen storage disease type VI can progress to cirrhosis: ten Chinese patients with GSD VI and a literature review
  15. Short Communication
  16. Screening for imprinting disorders in 58 patients with clinically diagnosed idiopathic short stature
  17. Case Reports
  18. ROHHAD syndrome – A still unrecognized cause of childhood obesity: report of three cases
  19. Carbonic anhydrase VA deficiency: a very rare case of hyperammonemic encephalopathy
  20. Idiopathic infantile hypercalcemia: mutations in SLC34A1 and CYP24A1 in two siblings and fathers
  21. GCK-MODY in a child with cystic fibrosis: the doubt of the treatment plan
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