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Evaluation of the relationship between the one-hour plasma glucose concentration and beta-cell functions and cardiometabolic parameters during oral glucose tolerance test in obese children and adolescents

  • Eda Mengen ORCID logo EMAIL logo and Seyit Ahmet Uçaktürk ORCID logo
Published/Copyright: May 24, 2020
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 33 Issue 6

Abstract

Background

In this study, we aimed to evaluate the relationship between the 1-h plasma glucose (PG) level in the oral glucose tolerance test (OGTT) and conventional glycemic parameters, indices evaluating beta-cell functions, and cardiometabolic risk factors.

Methods

The records of 532 obese patients who were followed up in the Pediatric Endocrinology Polyclinic and who underwent standard OGTT were evaluated retrospectively. All patients were divided into two groups according to OGTT data as the 1-h plasma glucose concentration <155 mg/dL (n=329) and ≥155 mg/dL (n=203). Patients with normal glucose tolerance (NGT) were divided into two groups according to the 1-h PG level, as 218 patients with NGT 1 h-low (<155 mg/dL) and 53 patients with high NGT 1 h-high (≥155 mg/dL).

Results

There was a statistically significant difference between the lipid profiles of individuals with NGT 1 h-low (<155 mg/dL) and individuals with NGT 1 h-high (≥155 mg/dL) (p<0.001). Total cholesterol, LDL cholesterol, and triglyceride levels were higher, while HDL cholesterol levels were lower in individuals with NGT 1 h-high (≥155 mg/dL). The indices evaluating beta-cell functions were significantly higher in individuals with NGT 1 h-low (<155 mg/dL).

Conclusion

As a result, a plasma glucose concentration above or equal to 155 mg/dL at 1 h during an OGTT is associated with a worse clinical phenotype characterized by changes in insulin sensitivity and β-cell function. Therefore, this threshold value can predict the progression of prediabetes in obese young people with NGT.

Keywords: beta-cell function; obesity; oral glucose tolerance test; 1-h plasma glucose level
Corresponding author: Eda Mengen, Department of Pediatric Endocrinology, Ankara City Hospital, Children's Hospital, Ankara, Turkey, Phone: +90 312 552 60 00, E-mail:

  1. Financial disclosure: No financial disclosure.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Conflict of interest: The authors declare no conflict of interest.

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Received: 2020-01-13
Accepted: 2020-03-19
Published Online: 2020-05-24

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Genetic characteristics and follow-up of patients with fatty acid β-oxidation disorders through expanded newborn screening in a Northern Chinese population
  4. Clinical and genetic investigation of 136 Japanese patients with congenital hypothyroidism
  5. Institutional experience of newborn screening for inborn metabolism disorders by tandem MS in the Turkish population
  6. Investigation of the effect of epicardial adipose tissue thickness on cardiac conduction system in children with type 1 diabetes mellitus
  7. Retrospective evaluation of 85 patients with urea cycle disorders: one center experience, three new mutations
  8. Circulating chemerin level may be associated with early vascular pathology in obese children without overt arterial hypertension – preliminary results
  9. A novel diagnostic tool for the evaluation of hypothalamic-pituitary region and diagnosis of growth hormone deficiency: pons ratio
  10. Growth status of children and adolescents born small for gestational age at full term in Korea: data from the KNHANES-V
  11. Children with onset-ketoacidosis are admitted to the nearest hospital available, regardless of center size
  12. Evaluation of α-klotho level in insulin dependent diabetes mellitus (IDDM) children
  13. Evaluation of the relationship between the one-hour plasma glucose concentration and beta-cell functions and cardiometabolic parameters during oral glucose tolerance test in obese children and adolescents
  14. Triglycerides/high-density lipoprotein cholesterol is a predictor similar to the triglyceride–glucose index for the diagnosis of metabolic syndrome using International Diabetes Federation criteria of insulin resistance in obese adolescents: a cross-sectional study
  15. Rapid progressive central precocious puberty: diagnostic and predictive value of basal sex hormone levels and pelvic ultrasound
  16. Mucopolysaccharidosis III in Mainland China: natural history, clinical and molecular characteristics of 34 patients
  17. Case Reports
  18. An infant presenting with extreme hypertriglyceridemia diagnosed as glycogen storage disease type Ia
  19. A novel heterozygous mutation in the insulin receptor gene presenting with type A severe insulin resistance syndrome
  20. Isolated premature menarche in two siblings with Neurofibromatosis type 1
  21. GAD-65 autoantibody associated epilepsy
https://doi.org/10.1515/jpem-2020-0016
Keywords for this article
beta-cell function; obesity; oral glucose tolerance test; 1-h plasma glucose level

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Genetic characteristics and follow-up of patients with fatty acid β-oxidation disorders through expanded newborn screening in a Northern Chinese population
  4. Clinical and genetic investigation of 136 Japanese patients with congenital hypothyroidism
  5. Institutional experience of newborn screening for inborn metabolism disorders by tandem MS in the Turkish population
  6. Investigation of the effect of epicardial adipose tissue thickness on cardiac conduction system in children with type 1 diabetes mellitus
  7. Retrospective evaluation of 85 patients with urea cycle disorders: one center experience, three new mutations
  8. Circulating chemerin level may be associated with early vascular pathology in obese children without overt arterial hypertension – preliminary results
  9. A novel diagnostic tool for the evaluation of hypothalamic-pituitary region and diagnosis of growth hormone deficiency: pons ratio
  10. Growth status of children and adolescents born small for gestational age at full term in Korea: data from the KNHANES-V
  11. Children with onset-ketoacidosis are admitted to the nearest hospital available, regardless of center size
  12. Evaluation of α-klotho level in insulin dependent diabetes mellitus (IDDM) children
  13. Evaluation of the relationship between the one-hour plasma glucose concentration and beta-cell functions and cardiometabolic parameters during oral glucose tolerance test in obese children and adolescents
  14. Triglycerides/high-density lipoprotein cholesterol is a predictor similar to the triglyceride–glucose index for the diagnosis of metabolic syndrome using International Diabetes Federation criteria of insulin resistance in obese adolescents: a cross-sectional study
  15. Rapid progressive central precocious puberty: diagnostic and predictive value of basal sex hormone levels and pelvic ultrasound
  16. Mucopolysaccharidosis III in Mainland China: natural history, clinical and molecular characteristics of 34 patients
  17. Case Reports
  18. An infant presenting with extreme hypertriglyceridemia diagnosed as glycogen storage disease type Ia
  19. A novel heterozygous mutation in the insulin receptor gene presenting with type A severe insulin resistance syndrome
  20. Isolated premature menarche in two siblings with Neurofibromatosis type 1
  21. GAD-65 autoantibody associated epilepsy
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