Triglycerides/high-density lipoprotein cholesterol is a predictor similar to the triglyceride–glucose index for the diagnosis of metabolic syndrome using International Diabetes Federation criteria of insulin resistance in obese adolescents: a cross-sectional study
-
Nazlı Nur Aslan Çin
,
Hülya Yardımcı
,
Nevra Koç
Abstract
Objectives
Metabolic syndrome (MS) is a fatal endocrinopathy that begins with insulin resistance (IR) and causes abdominal obesity, glucose intolerance, or systemic disorders. This study was aimed to determine the cut-off values for the triglyceride (TG)/high-density lipoprotein cholesterol (TG/HDL-C) ratio, the TG glucose (TyG) index and homeostasis model assessment (HOMA-IR) for the diagnosis of MS in obese adolescents, and to compare which of the three indexes would offer a more accurate approach to diagnosis.
Methods
The study population comprised 1,171 obese adolescents (639 females and 532 males aged 10–16 years, Body Mass Index (BMI)>=95th percentile). Indirect measures of IR screening for MS were the TG/HDL ratio, TyG index, and HOMA-IR. The cut-off values of the TG/HDL ratio, TyG index, and HOMA-IR were obtained from receiver operation characteristic (ROC) curves.
Results
HOMA-IR had a significant positive correlation with the TyG index (r=0.352, p<0.001) and TG/HDL-C (r=0.291, p<.001). The TyG index and TG/HDL-C showed a strong positive correlation (r=0.901, p<0.001). The TG/HDL-C ratio showed a larger ROC Area under Curve (AUC=0.849) than HOMA-IR index (AUC=0.689), but as a predictor similar to TyG index (AUC=0.833) when screening for MS. The cut-off values for MS were as follows: TG/HDL-C ratio>2.16 (sensitivity: 88.8%; specificity: 49.7%), TyG index>8.50 (sensitivity: 85.6%; specificity: 57.0%) and HOMA-IR>2.52 (sensitivity: 83.2%; specificity: 40.4%).
Conclusions
Both the TyG index and TG/HDL-C ratio are better markers than HOMA-IR to determine the risk of metabolic syndrome according to IDF criteria. Besides, the TyG index and TG/HDL-C ratio have similar differentiating powers to determine this risk in obese Turkish adolescents.
Author contributions: NNAÇ and HY designed the study. NNAÇ and MAO performed the analysis. NNAÇ, HY and MAO drafted the initial manuscript and NK and SAU revised the manuscript; NNAÇ, MAO and HY provided important advice for the calculations, reviewed and revised the manuscript making important intellectual contributions; All authors read and approved the final manuscript.
Competing interests: The authors declare no conflict of interest.
Employment or leadership: None declared.
Honorarium: None declared.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Original Articles
- Genetic characteristics and follow-up of patients with fatty acid β-oxidation disorders through expanded newborn screening in a Northern Chinese population
- Clinical and genetic investigation of 136 Japanese patients with congenital hypothyroidism
- Institutional experience of newborn screening for inborn metabolism disorders by tandem MS in the Turkish population
- Investigation of the effect of epicardial adipose tissue thickness on cardiac conduction system in children with type 1 diabetes mellitus
- Retrospective evaluation of 85 patients with urea cycle disorders: one center experience, three new mutations
- Circulating chemerin level may be associated with early vascular pathology in obese children without overt arterial hypertension – preliminary results
- A novel diagnostic tool for the evaluation of hypothalamic-pituitary region and diagnosis of growth hormone deficiency: pons ratio
- Growth status of children and adolescents born small for gestational age at full term in Korea: data from the KNHANES-V
- Children with onset-ketoacidosis are admitted to the nearest hospital available, regardless of center size
- Evaluation of α-klotho level in insulin dependent diabetes mellitus (IDDM) children
- Evaluation of the relationship between the one-hour plasma glucose concentration and beta-cell functions and cardiometabolic parameters during oral glucose tolerance test in obese children and adolescents
- Triglycerides/high-density lipoprotein cholesterol is a predictor similar to the triglyceride–glucose index for the diagnosis of metabolic syndrome using International Diabetes Federation criteria of insulin resistance in obese adolescents: a cross-sectional study
- Rapid progressive central precocious puberty: diagnostic and predictive value of basal sex hormone levels and pelvic ultrasound
- Mucopolysaccharidosis III in Mainland China: natural history, clinical and molecular characteristics of 34 patients
- Case Reports
- An infant presenting with extreme hypertriglyceridemia diagnosed as glycogen storage disease type Ia
- A novel heterozygous mutation in the insulin receptor gene presenting with type A severe insulin resistance syndrome
- Isolated premature menarche in two siblings with Neurofibromatosis type 1
- GAD-65 autoantibody associated epilepsy
Articles in the same Issue
- Frontmatter
- Original Articles
- Genetic characteristics and follow-up of patients with fatty acid β-oxidation disorders through expanded newborn screening in a Northern Chinese population
- Clinical and genetic investigation of 136 Japanese patients with congenital hypothyroidism
- Institutional experience of newborn screening for inborn metabolism disorders by tandem MS in the Turkish population
- Investigation of the effect of epicardial adipose tissue thickness on cardiac conduction system in children with type 1 diabetes mellitus
- Retrospective evaluation of 85 patients with urea cycle disorders: one center experience, three new mutations
- Circulating chemerin level may be associated with early vascular pathology in obese children without overt arterial hypertension – preliminary results
- A novel diagnostic tool for the evaluation of hypothalamic-pituitary region and diagnosis of growth hormone deficiency: pons ratio
- Growth status of children and adolescents born small for gestational age at full term in Korea: data from the KNHANES-V
- Children with onset-ketoacidosis are admitted to the nearest hospital available, regardless of center size
- Evaluation of α-klotho level in insulin dependent diabetes mellitus (IDDM) children
- Evaluation of the relationship between the one-hour plasma glucose concentration and beta-cell functions and cardiometabolic parameters during oral glucose tolerance test in obese children and adolescents
- Triglycerides/high-density lipoprotein cholesterol is a predictor similar to the triglyceride–glucose index for the diagnosis of metabolic syndrome using International Diabetes Federation criteria of insulin resistance in obese adolescents: a cross-sectional study
- Rapid progressive central precocious puberty: diagnostic and predictive value of basal sex hormone levels and pelvic ultrasound
- Mucopolysaccharidosis III in Mainland China: natural history, clinical and molecular characteristics of 34 patients
- Case Reports
- An infant presenting with extreme hypertriglyceridemia diagnosed as glycogen storage disease type Ia
- A novel heterozygous mutation in the insulin receptor gene presenting with type A severe insulin resistance syndrome
- Isolated premature menarche in two siblings with Neurofibromatosis type 1
- GAD-65 autoantibody associated epilepsy
