Long-term effects of GnRH agonist treatment on body mass index in girls with idiopathic central precocious puberty
-
Dogus Vuralli
,
Zeynep Alev Ozon
Abstract
Introduction
Studies evaluating effects of gonadotropin-releasing hormone agonist (GnRHa) on weight and body-mass-index (BMI) in girls with idiopathic central precocious puberty (iCPP) include short-term effects. The aim of this study is to investigate changes in BMI during and 2 years after completion of GnRHa to determine the factors that may impact BMI in girls with iCPP.
Methods
Medical files of 138 girls who completed GnRHa were evaluated. All patients had weight and height measurements at the beginning and end of treatment, and 111 patients had anthropometric measurements 2 years after the completion of treatment.
Results
In the beginning, 82 (59.4%) had normal weight (NW), 42 (30.4%) were overweight (OW), and 14 (10.2%) were obese (OB). Analysis of BMI-standard deviation score (SDS) in the whole group showed an overall increase during GnRHa treatment (0.92 ± 0.74 vs. 1.20 ± 0.51, p < 0.001). Changes in BMI-SDS (ΔBMI-SDS) during GnRHa differed between NW and OW/OB (0.45 ± 0.31 vs. 0.03 ± 0.20, p < 0.001). BMI-SDSs of both groups returned to baseline scores (or initial levels) 2 years after the completion of treatment. Two factors affecting ΔBMI-SDS in multiple linear regression analyses were baseline BMI and Δheight-SDS, both correlated negatively with ΔBMI-SDS.
Conclusions
The present study is one of the studies evaluating BMI change over a long period of time in girls with CPP. Although BMI-SDS increased during GnRHa in NW girls, it was reversible in follow-up after treatment. However, BMI-SDS did not change during and in follow-up in OW/OB girls. Conserving BMI-SDS in OW/OB girls may be related to the fact that weight management programs were recommended for these patients. Dietary recommendations should be provided for children with NW who undergo GnRHa, as is the case for OW patients.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.
Conflict of interest: The authors declare that they have no conflict of interest.
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©2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Inborn errors of metabolism
- Reviews
- Nutrition and medical support during pregnancy and lactation in women with inborn errors of intermediary metabolism disorders (IEMDs)
- The association between prenatal exposure to organochlorine compounds and neonatal thyroid hormone levels: a systematic review
- Original Articles
- Investigating the incidence rate and geographical distribution of congenital hypothyroidism among neonates in Isfahan province using geographic information system (GIS) between 2002 and 2015
- Analysis of five cases of hypermethioninemia diagnosed by neonatal screening
- What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature
- Machine learning-based prediction of response to growth hormone treatment in Turner syndrome: the LG Growth Study
- Pathogenic/likely pathogenic variants in the SHOX, GHR and IGFALS genes among Indian children with idiopathic short stature
- Celiac disease in Saudi children with isolated short stature: is it rare or are we not screening rigorously enough?
- The beneficial effect of psychological support on mothers with PKU children who suffer from social discrimination and damage of quality of life
- Long-term effects of GnRH agonist treatment on body mass index in girls with idiopathic central precocious puberty
- Sudden sex hormone withdrawal and the effects on body composition in late pubertal adolescents with gender dysphoria
- The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy
- BMI relationship to the onset of puberty: assessment of growth parameters and sexual maturity changes in Egyptian children and adolescents of both sexes
- The effects of a 12-week jump rope exercise program on body composition, insulin sensitivity, and academic self-efficacy in obese adolescent girls
- Onset of pituitary hormone deficiencies in optic nerve hypoplasia: a temporal trend analysis of 32 children at Mayo Clinic
- Dietary practices in methylmalonic acidaemia: a European survey
- Case Reports
- Clinical findings in five Turkish patients with citrin deficiency and identification of a novel mutation on SLC25A13
- A rare case of primary coenzyme Q10 deficiency due to COQ9 mutation
- Sinusitis, an under-reported adverse effect in children treated with radioactive iodine therapy and review of the current literature
- Acknowledgment
Articles in the same Issue
- Frontmatter
- Editorial
- Inborn errors of metabolism
- Reviews
- Nutrition and medical support during pregnancy and lactation in women with inborn errors of intermediary metabolism disorders (IEMDs)
- The association between prenatal exposure to organochlorine compounds and neonatal thyroid hormone levels: a systematic review
- Original Articles
- Investigating the incidence rate and geographical distribution of congenital hypothyroidism among neonates in Isfahan province using geographic information system (GIS) between 2002 and 2015
- Analysis of five cases of hypermethioninemia diagnosed by neonatal screening
- What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature
- Machine learning-based prediction of response to growth hormone treatment in Turner syndrome: the LG Growth Study
- Pathogenic/likely pathogenic variants in the SHOX, GHR and IGFALS genes among Indian children with idiopathic short stature
- Celiac disease in Saudi children with isolated short stature: is it rare or are we not screening rigorously enough?
- The beneficial effect of psychological support on mothers with PKU children who suffer from social discrimination and damage of quality of life
- Long-term effects of GnRH agonist treatment on body mass index in girls with idiopathic central precocious puberty
- Sudden sex hormone withdrawal and the effects on body composition in late pubertal adolescents with gender dysphoria
- The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy
- BMI relationship to the onset of puberty: assessment of growth parameters and sexual maturity changes in Egyptian children and adolescents of both sexes
- The effects of a 12-week jump rope exercise program on body composition, insulin sensitivity, and academic self-efficacy in obese adolescent girls
- Onset of pituitary hormone deficiencies in optic nerve hypoplasia: a temporal trend analysis of 32 children at Mayo Clinic
- Dietary practices in methylmalonic acidaemia: a European survey
- Case Reports
- Clinical findings in five Turkish patients with citrin deficiency and identification of a novel mutation on SLC25A13
- A rare case of primary coenzyme Q10 deficiency due to COQ9 mutation
- Sinusitis, an under-reported adverse effect in children treated with radioactive iodine therapy and review of the current literature
- Acknowledgment
