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Panhypopituitarism from neurosarcoidosis in an adolescent: case report and literature review

  • Anju Sukumaran EMAIL logo
Published/Copyright: July 25, 2019
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 32 Issue 9

Abstract

Background

Neurosarcoidosis is not a common entity from an endocrinology standpoint. Prompt diagnosis is essential in order to determine appropriate treatment and to establish prognosis.

Case presentation

Our case illustrates the difficulties encountered in making a diagnosis of sarcoidosis in an adolescent who presented with polyuria, polydipsia and hypernatremia. She developed panhypopituitarism and her deficits did not improve after treatment.

Conclusion

Pediatric endocrinologists diagnose and treat panhypopituitarism associated with many conditions. Neurosarcoidosis should be considered as part of the diagnosis in patients with panhypopituitarism, especially if there is evidence of multi organ disease. Case reports can effectively address the gap in knowledge due to the limited exposure of physicians to this field, especially in children.

Keywords: neurosarcoidosis; panhypopituitarism; pediatric
Corresponding author: Anju Sukumaran, MD, Assistant Professor, Division of Pediatric Endocrinology, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS-39216, USA, Phone: +601 984 5246

  1. Author contributions: Author has accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

  6. Ethical statement: This is a case report and hence there is no research or IRB approval required. There are no identifiers about the patient in the case report and hence no consent was obtained.

References

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpem-2019-0110).

Received: 2019-03-03
Accepted: 2019-05-04
Published Online: 2019-07-25
Published in Print: 2019-09-25

© 2019 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Association of the 3′UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity
  4. Future glycemic control of children diagnosed with type 1 diabetes mellitus at toddler and preschool/school age
  5. Children with type 1 diabetes of early age at onset – immune and metabolic phenotypes
  6. Determination of cerebral edema with serial measurement of optic nerve sheath diameter during treatment in children with diabetic ketoacidosis: a longitudinal study
  7. Association between inflammation, oxidative stress, vitamin D, copper and zinc with pre-obesity and obesity in school children from the city of Podgorica, Montenegro
  8. Phenotypic diversity and correlation with the genotypes of pseudohypoaldosteronism type 1
  9. Start low, go slowly – mental abnormalities in young prolactinoma patients under cabergoline therapy
  10. Primary ovarian insufficiency in an adolescent population: clinical phenotype and diagnostic approach
  11. Novel combined insulin-like 3 variations of a single nucleotide in cryptorchidism
  12. Evaluation of the abdominopelvic region using MRI in patients with primary amenorrhea
  13. Benefits of aerobic training in girls with precocious puberty: involvement of CRP and cortisol
  14. The relationship between the olfactory bulb and precocious puberty: from the nose to the pituitary
  15. Short Communication
  16. Experience with intramuscular glucagon for infants with early neonatal hypoglycemia
  17. Case Reports
  18. A novel GATA6 variant in a boy with neonatal diabetes and diaphragmatic hernia: a familial case with a review of the literature
  19. Nephrogenic diabetes insipidus in a 15-year-old Hispanic female with a novel AQP2 mutation
  20. Pediatric stroke as the presenting symptom of new-onset type 1 diabetes mellitus without DKA: case report and literature review
  21. Panhypopituitarism from neurosarcoidosis in an adolescent: case report and literature review
https://doi.org/10.1515/jpem-2019-0110
Keywords for this article
neurosarcoidosis; panhypopituitarism; pediatric

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Association of the 3′UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity
  4. Future glycemic control of children diagnosed with type 1 diabetes mellitus at toddler and preschool/school age
  5. Children with type 1 diabetes of early age at onset – immune and metabolic phenotypes
  6. Determination of cerebral edema with serial measurement of optic nerve sheath diameter during treatment in children with diabetic ketoacidosis: a longitudinal study
  7. Association between inflammation, oxidative stress, vitamin D, copper and zinc with pre-obesity and obesity in school children from the city of Podgorica, Montenegro
  8. Phenotypic diversity and correlation with the genotypes of pseudohypoaldosteronism type 1
  9. Start low, go slowly – mental abnormalities in young prolactinoma patients under cabergoline therapy
  10. Primary ovarian insufficiency in an adolescent population: clinical phenotype and diagnostic approach
  11. Novel combined insulin-like 3 variations of a single nucleotide in cryptorchidism
  12. Evaluation of the abdominopelvic region using MRI in patients with primary amenorrhea
  13. Benefits of aerobic training in girls with precocious puberty: involvement of CRP and cortisol
  14. The relationship between the olfactory bulb and precocious puberty: from the nose to the pituitary
  15. Short Communication
  16. Experience with intramuscular glucagon for infants with early neonatal hypoglycemia
  17. Case Reports
  18. A novel GATA6 variant in a boy with neonatal diabetes and diaphragmatic hernia: a familial case with a review of the literature
  19. Nephrogenic diabetes insipidus in a 15-year-old Hispanic female with a novel AQP2 mutation
  20. Pediatric stroke as the presenting symptom of new-onset type 1 diabetes mellitus without DKA: case report and literature review
  21. Panhypopituitarism from neurosarcoidosis in an adolescent: case report and literature review
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