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The effect of thyroid functions on osteopenia of prematurity in preterm infants

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Published/Copyright: December 4, 2018
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 32 Issue 1

Abstract

Background

It is known that thyroid hormones have effects on bone development. In particular, the effect of thyroid hormones on osteopenia of prematurity (OOP) has not been examined in preterm infants. Our study aimed to examine the relationship between OOP and congenital hypothyroidism (CH) in preterm infants.

Methods

Very low birth weight infants (VLBW, <1500 g) were included in the study. Thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels were measured on postnatal day 5. Serum calcium, phosphorus and alkaline phosphatase (ALP) levels were studied as standard screening parameters for OOP at postnatal week 4. Patients with serum ALP level >700 IU/L were included in the OOP group. We intended to figure out the relationship between OOP and CH in infants.

Results

In our study, OOP frequency was 14.9% among 543 VLBW infants. There was no statistically significant difference between groups with and without CH (21.7% and 14.8%, respectively) in terms of OOP (p=0.632). Gestational age (GA) was significantly lower in infants with diagnosed OOP (p<0.001, p<0.001, respectively). In addition, the prevalence rates of mothers with preeclampsia, small for gestational age (SGA), respiratory support requirement, late-onset neonatal sepsis (LOS), bronchopulmonary dysplasia (BPD) and full enteral feeding time were found to be higher in the OOP group (p<0.05).

Conclusions

We found that thyroid hormones had no effect on OOP in preterm infants. Therefore, future randomized controlled studies as well as long-term outcome studies are warranted on this topic.

Keywords: congenital hypothyroidism; osteopenia of prematurity; thyroid function tests; very low birth weight preterm
Corresponding author: Ufuk Çakır, MD, Division of Neonatology, Zekai Tahir Burak Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Altıntag, Ankara, Turkey, Phone: +90 505 8581781, Fax: +90 312 2315781

  1. Author contributions: Concept, design and data collection or processing: Ufuk Cakir. Data analysis and interpretation: Cuneyt Tayman. Literature search: Ufuk Cakir and Cuneyt Tayman. Writing: Ufuk Cakir and Cuneyt Tayman.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2018-10-05
Accepted: 2018-11-11
Published Online: 2018-12-04
Published in Print: 2019-01-28

©2019 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Status and trends in the use of insulin analogs, insulin delivery systems and their association with glycemic control: comparison of the two consecutive recent cohorts of Japanese children and adolescents with type 1 diabetes mellitus
  4. Utilizing serum bicarbonate instead of venous pH to transition from intravenous to subcutaneous insulin shortens the duration of insulin infusion in pediatric diabetic ketoacidosis
  5. Fatty pancreas in relation to insulin resistance and metabolic syndrome in children with obesity
  6. Adiponectin, leptin and high sensitivity C-reactive protein values in obese children – important markers for metabolic syndrome?
  7. No clinical utility of common polymorphisms in IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 genes previously associated with insulin resistance in overweight children from Romania and Moldova
  8. Skin autofluorescence in children with and without obesity
  9. Utility of anthropometric indicators to screen for clustered cardiometabolic risk factors in children and adolescents
  10. Long-acting intramuscular ACTH stimulation test for the diagnosis of secondary adrenal insufficiency in children
  11. The effect of thyroid functions on osteopenia of prematurity in preterm infants
  12. Using the PHQ-9 and GAD-7 to screen for acute distress in transgender youth: findings from a pediatric endocrinology clinic
  13. Sex assignment practice in disorders of sexual differentiation: survey results from paediatric endocrinologists in the Arab region
  14. Letter to the Editor
  15. Columbus’ egg: a practical approach to nutritional management in maple syrup urine disease
  16. Case Reports
  17. Aromatase excess syndrome in a Chinese boy due to a novel duplication at 15q21.2
  18. A Turkish girl with H syndrome: stunted growth and development of autoimmune insulin dependent diabetes mellitus in the 6th year of diagnosis
  19. Familial ROBO1 deletion associated with ectopic posterior pituitary, duplication of the pituitary stalk and anterior pituitary hypoplasia
https://doi.org/10.1515/jpem-2018-0429
Keywords for this article
congenital hypothyroidism; osteopenia of prematurity; thyroid function tests; very low birth weight preterm

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Status and trends in the use of insulin analogs, insulin delivery systems and their association with glycemic control: comparison of the two consecutive recent cohorts of Japanese children and adolescents with type 1 diabetes mellitus
  4. Utilizing serum bicarbonate instead of venous pH to transition from intravenous to subcutaneous insulin shortens the duration of insulin infusion in pediatric diabetic ketoacidosis
  5. Fatty pancreas in relation to insulin resistance and metabolic syndrome in children with obesity
  6. Adiponectin, leptin and high sensitivity C-reactive protein values in obese children – important markers for metabolic syndrome?
  7. No clinical utility of common polymorphisms in IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 genes previously associated with insulin resistance in overweight children from Romania and Moldova
  8. Skin autofluorescence in children with and without obesity
  9. Utility of anthropometric indicators to screen for clustered cardiometabolic risk factors in children and adolescents
  10. Long-acting intramuscular ACTH stimulation test for the diagnosis of secondary adrenal insufficiency in children
  11. The effect of thyroid functions on osteopenia of prematurity in preterm infants
  12. Using the PHQ-9 and GAD-7 to screen for acute distress in transgender youth: findings from a pediatric endocrinology clinic
  13. Sex assignment practice in disorders of sexual differentiation: survey results from paediatric endocrinologists in the Arab region
  14. Letter to the Editor
  15. Columbus’ egg: a practical approach to nutritional management in maple syrup urine disease
  16. Case Reports
  17. Aromatase excess syndrome in a Chinese boy due to a novel duplication at 15q21.2
  18. A Turkish girl with H syndrome: stunted growth and development of autoimmune insulin dependent diabetes mellitus in the 6th year of diagnosis
  19. Familial ROBO1 deletion associated with ectopic posterior pituitary, duplication of the pituitary stalk and anterior pituitary hypoplasia
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