Home Medicine Prevalence of dyslipidemia and factors affecting dyslipidemia in young adults with type 1 diabetes: evaluation of statin prescribing
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Prevalence of dyslipidemia and factors affecting dyslipidemia in young adults with type 1 diabetes: evaluation of statin prescribing

  • Elie Abed , Brenton LaBarbera , Justin Dvorak , Ying Zhang , Joni Beck and Mitali Talsania EMAIL logo
Published/Copyright: March 12, 2019
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 32 Issue 4

Abstract

Background

There is limited information about cardiovascular complications among young adults (YA) with type 1 diabetes mellitus (T1DM) who are transitioning from pediatric to adult care. We aimed to study the prevalence and associated factors of dyslipidemia (DLD) and statin treatment in these patients.

Methods

We recruited 129 YA with T1DM aged 15–25 years. In a cross-sectional analysis, the prevalence of DLD (low-density lipoprotein cholesterol [LDL-C] ≥ 100 mg/dL, high-density lipoprotein cholesterol [HDL-C] <40 mg/dL [males] or <50 mg/dL [females], total cholesterol [TC] ≥200 mg/dL or triglycerides [TG] ≥150 mg/dL) was reported. Socioeconomic and clinical characteristics were compared between YA with and without DLD. We also assessed statin use among YA with DLD.

Results

DLD was found in 64% of YA, predominantly increased LDL-C (34.9%). Higher mean glycated hemoglobin (HbA1c) was associated with DLD (p < 0.043). Of all YA who met the criteria for statin therapy, only 42% had one prescribed.

Conclusions

The prevalence of DLD is high in YA with T1DM and is associated with poor glycemic control, and use of statin therapy in this high-risk population is low.

Keywords: dyslipidemia; statin; type 1 diabetes; young adults
Corresponding author: Mitali Talsania, MD, Assistant Professor of Endocrinology, Department of Adult Endocrinology, University of Oklahoma Health Sciences Center, 1000 N, Lincoln Blvd, Suite 2900, Oklahoma City, OK, USA; and Harold Hamm Diabetes Center, Oklahoma City, OK, USA, Phone: +405-271-5896, Fax: +405-271-7522

  1. Disclosure: No potential conflict of interest relevant to this article was reported.

  2. Author contributions: All authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Research funding: This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.

  4. Employment or leadership: None declared.

  5. Honorarium: None declared.

  6. Competing interest: The funding organization played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of report; or in the decision to submit the report for publication.

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Received: 2018-09-05
Accepted: 2019-01-30
Published Online: 2019-03-12
Published in Print: 2019-04-24

©2019 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. The importance of anthropological methods in the diagnosis of rare diseases
  4. Original Articles
  5. PON1 arylesterase activity, HDL functionality and their correlation in malnourished children
  6. Prevalence of dyslipidemia and factors affecting dyslipidemia in young adults with type 1 diabetes: evaluation of statin prescribing
  7. Myocardial dysfunction in relation to serum thiamine levels in children with diabetic ketoacidosis
  8. Evaluation of long-term follow-up and methimazole therapy outcomes of pediatric Graves’ disease: a single-center experience
  9. Endocrine consequences of neuroblastoma treatment in children: 20 years’ experience of a single center
  10. Analysis of diabetes-associated autoantibodies in children and adolescents with autoimmune thyroid diseases
  11. Adrenal function of extremely premature infants in the first 5 days after birth
  12. Atypical presentation of Leydig cell tumour in three prepubertal patients: diagnosis, treatment and outcomes
  13. The diagnosis of cystinosis in patients reveals new CTNS gene mutations in the Chinese population
  14. Comparing the validity of continuous metabolic syndrome risk scores for predicting pediatric metabolic syndrome: the CASPIAN-V study
  15. Primary pigmented nodular adrenocortical disease (PPNAD): single centre experience
  16. Short Communication
  17. Classical galactosemia patients can achieve high IQ scores
  18. Case Reports
  19. Idiopathic gonadotropin-independent precocious puberty – is regular surveillance required?
  20. MYT1L mutation in a patient causes intellectual disability and early onset of obesity: a case report and review of the literature
  21. A case report and literature review of monoallelic mutation of GHR
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https://doi.org/10.1515/jpem-2018-0383
Keywords for this article
dyslipidemia; statin; type 1 diabetes; young adults

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. The importance of anthropological methods in the diagnosis of rare diseases
  4. Original Articles
  5. PON1 arylesterase activity, HDL functionality and their correlation in malnourished children
  6. Prevalence of dyslipidemia and factors affecting dyslipidemia in young adults with type 1 diabetes: evaluation of statin prescribing
  7. Myocardial dysfunction in relation to serum thiamine levels in children with diabetic ketoacidosis
  8. Evaluation of long-term follow-up and methimazole therapy outcomes of pediatric Graves’ disease: a single-center experience
  9. Endocrine consequences of neuroblastoma treatment in children: 20 years’ experience of a single center
  10. Analysis of diabetes-associated autoantibodies in children and adolescents with autoimmune thyroid diseases
  11. Adrenal function of extremely premature infants in the first 5 days after birth
  12. Atypical presentation of Leydig cell tumour in three prepubertal patients: diagnosis, treatment and outcomes
  13. The diagnosis of cystinosis in patients reveals new CTNS gene mutations in the Chinese population
  14. Comparing the validity of continuous metabolic syndrome risk scores for predicting pediatric metabolic syndrome: the CASPIAN-V study
  15. Primary pigmented nodular adrenocortical disease (PPNAD): single centre experience
  16. Short Communication
  17. Classical galactosemia patients can achieve high IQ scores
  18. Case Reports
  19. Idiopathic gonadotropin-independent precocious puberty – is regular surveillance required?
  20. MYT1L mutation in a patient causes intellectual disability and early onset of obesity: a case report and review of the literature
  21. A case report and literature review of monoallelic mutation of GHR
  22. Pitfalls in the diagnosis of insulin autoimmune syndrome (Hirata’s disease) in a hypoglycemic child: a case report and review of the literature
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