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Decrease in serum chemerin through aerobic exercise plus dieting and its association with mitigation of cardio-metabolic risk in obese female adolescents

  • Min Liu , Xiaojing Lin and Xiaohui Wang EMAIL logo
Published/Copyright: January 8, 2018
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 31 Issue 2

Abstract

Background:

The objective of this study was to determine the effects of a 4-week aerobic exercise plus dieting intervention on serum chemerin in obese female adolescents and its possible role in mitigating cardio-metabolic risk including glucose and lipid metabolism, central fat and inflammation.

Methods:

Fifty obese female adolescents were randomly divided into two groups: exercise plus dieting group (n=30) and dieting group (n=20). The participants in the exercise plus dieting group completed 4 weeks of moderate aerobic exercise combined with dieting, while the subjects in the dieting group undertook only dieting. Before and after the experiments, anthropometric index, parameters of glucose and lipid metabolism, serum chemerin and classic inflammatory indicators (C-reactive protein [CRP], tumor necrosis factor-α [TNF-α], interleukin-1β [IL-1β], IL-6, leptin and adiponectin) were measured.

Results:

Compared with the dieting group, a decrease in serum chemerin was found in the exercise plus dieting group, accompanied by significant improvements in anthropometric index, glucose and lipid metabolism and inflammatory factors. In addition, a higher serum chemerin level was found in obese adolescents with metabolic syndrome (MetS), and the disappearance of MetS induced by exercise plus dieting might be related to the decrease in chemerin. Correlation analysis showed the correlations of the decrease in chemerin with the changes in body fat, glucose and lipid metabolic index, leptin and adiponectin/leptin ratio.

Conclusions:

This is the first report that as short a duration as 4-week aerobic exercise plus dieting decreased serum chemerin in obese female adolescents, which might be associated with the improvement in glucose and lipid metabolism, mitigation of inflammation and decrease in MetS incidence, thus lowering cardio-metabolic risk, while no health benefit resulted from slight dieting.

Keywords: adolescents; aerobic exercise; chemerin; inflammation; obesity

  1. Author contributions: Xiaohui Wang conceived and designed the research; Min Liu and Xiaojing Lin performed the experiments, analyzed the data and interpreted the results of the experiments; Xiaohui Wang drafted, edited and revised the manuscript. All authors approved the final version of the paper. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was supported by grants from the National Natural Science Foundation of China (No. 31271274) and from Shanghai Key Lab of Human Performance (Shanghai University of Sport) (No. 11DZ2261100).

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2017-10-19
Accepted: 2017-11-28
Published Online: 2018-1-8
Published in Print: 2018-1-26

©2018 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. The role of corticosteroid-binding globulin in the evaluation of adrenal insufficiency
  4. Original Articles
  5. Association of sodium intake with insulin resistance in Korean children and adolescents: the Korea National Health and Nutrition Examination Survey 2010
  6. Decrease in serum chemerin through aerobic exercise plus dieting and its association with mitigation of cardio-metabolic risk in obese female adolescents
  7. Ultrasonographic assessment of pubertal breast development in obese children: compliance with the clinic
  8. Associations of leptin, insulin and lipids with retinal microvasculature in children and adolescents
  9. Association of cord blood ghrelin, leptin and insulin concentrations in term newborns with anthropometric parameters at birth
  10. Management of thyrotoxicosis in children and adolescents: 35 years’ experience in 304 patients
  11. Clinical and cytogenetic features of 516 patients with suspected Turner syndrome – a single-center experience
  12. Response to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty
  13. Reference centile curves for wrist circumference for Indian children aged 3–18 years
  14. Comparison between two inhibin B ELISA assays in 46,XY testicular disorders of sex development (DSD) with normal testosterone secretion
  15. Genetic mutations associated with neonatal diabetes mellitus in Omani patients
  16. Four novel mutations of the BCKDHA, BCKDHB and DBT genes in Iranian patients with maple syrup urine disease
  17. Improved medical-alert ID ownership and utilization in youth with congenital adrenal hyperplasia following a parent educational intervention
  18. Letter to the Editor
  19. Identification of five mutations in a patient with galactose metabolic disorders
  20. Case Reports
  21. Partial androgen insensitivity syndrome due to somatic mosaicism of the androgen receptor
  22. Vaginal bleeding and a giant ovarian cyst in an infant with 21-hydroxylase deficiency
  23. Insulin-mediated pseudoacromegaly: a report of two pediatric patients
  24. Novel compound heterozygous variants in the LHCGR gene identified in a subject with Leydig cell hypoplasia type 1
https://doi.org/10.1515/jpem-2017-0431
Keywords for this article
adolescents; aerobic exercise; chemerin; inflammation; obesity

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. The role of corticosteroid-binding globulin in the evaluation of adrenal insufficiency
  4. Original Articles
  5. Association of sodium intake with insulin resistance in Korean children and adolescents: the Korea National Health and Nutrition Examination Survey 2010
  6. Decrease in serum chemerin through aerobic exercise plus dieting and its association with mitigation of cardio-metabolic risk in obese female adolescents
  7. Ultrasonographic assessment of pubertal breast development in obese children: compliance with the clinic
  8. Associations of leptin, insulin and lipids with retinal microvasculature in children and adolescents
  9. Association of cord blood ghrelin, leptin and insulin concentrations in term newborns with anthropometric parameters at birth
  10. Management of thyrotoxicosis in children and adolescents: 35 years’ experience in 304 patients
  11. Clinical and cytogenetic features of 516 patients with suspected Turner syndrome – a single-center experience
  12. Response to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty
  13. Reference centile curves for wrist circumference for Indian children aged 3–18 years
  14. Comparison between two inhibin B ELISA assays in 46,XY testicular disorders of sex development (DSD) with normal testosterone secretion
  15. Genetic mutations associated with neonatal diabetes mellitus in Omani patients
  16. Four novel mutations of the BCKDHA, BCKDHB and DBT genes in Iranian patients with maple syrup urine disease
  17. Improved medical-alert ID ownership and utilization in youth with congenital adrenal hyperplasia following a parent educational intervention
  18. Letter to the Editor
  19. Identification of five mutations in a patient with galactose metabolic disorders
  20. Case Reports
  21. Partial androgen insensitivity syndrome due to somatic mosaicism of the androgen receptor
  22. Vaginal bleeding and a giant ovarian cyst in an infant with 21-hydroxylase deficiency
  23. Insulin-mediated pseudoacromegaly: a report of two pediatric patients
  24. Novel compound heterozygous variants in the LHCGR gene identified in a subject with Leydig cell hypoplasia type 1
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