Phenotypic presentation of adolescents with overt primary hypothyroidism
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Nandini Devru
Abstract
Background:
The phenotypic presentation of overt hypothyroidism during adolescence is less well characterized. The aim of the study was to study the phenotypic presentation of patients with overt hypothyroidism presenting during adolescence (age 9–18 years).
Methods:
Records of adolescent patients with overt hypothyroidism (thyroid stimulating hormone [TSH]>10 mIU/L) were retrospectively analyzed for presenting complaints, height and pubertal status.
Results:
A total of 67 patients (40 females and 37 males, average age 13.2+2.3 years) with a mean TSH of 241.3±336.6 mIU/L were included. The commonest presentation was short stature in 46.2% of patients followed by neck swelling (16.4%) and weight gain (11.9%). The mean height standard deviation score (SDS) was −2.5+2.11, 43% of patients had less than 3 SDS. The height age and bone age were around 3 years less than the chronological age. The bone age significantly correlated with the height age but not with TSH levels. Three patients referred from neurology with primary complaints of headache had pituitary hyperplasia and one presented with hypokalemic periodic paralysis. Seven had delayed puberty and one patient had early periods due to huge ovarian cysts.
Conclusions:
In the present study, severe short stature and uncommon phenotypic presentations were a consequence of long-standing severe untreated hypothyroidism.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Articles in the same Issue
- Frontmatter
- Original Articles
- HbA1c levels in children with type 1 diabetes and correlation to diabetic retinopathy
- Relationship between urinary sodium-creatinine ratios and insulin resistance in Korean children and adolescents with obesity
- Prevalence of comorbid conditions pre-existing and diagnosed at a tertiary care pediatric weight management clinic
- The relationship between diet quality and insulin resistance in obese children: adaptation of the Healthy Lifestyle-Diet Index in Turkey
- Outcomes of mitochondrial derived diseases: a single-center experience
- Metabolic and genetic markers’ associations with elevated levels of alanine aminotransferase in adolescents
- Phenotypic presentation of adolescents with overt primary hypothyroidism
- Growth velocity and biological variables during puberty in achondroplasia
- Employing a results-based algorithm to reduce laboratory utilization in ACTH stimulation testing
- Investigating the changes in amino acid values in premature infants: a pilot study
- A hierarchical Bayesian tri-variate analysis on factors associated with anthropometric measures in a large sample of children and adolescents: the CASPIAN-IV study
- Smith-Lemli-Opitz syndrome: clinical and biochemical correlates
- Case Reports
- Sporadic pediatric papillary thyroid carcinoma harboring the ETV6/NTRK3 fusion oncogene in a 7-year-old Japanese girl: a case report and review of literature
- Hypercalcemia, hyperkalemia and supraventricular tachycardia in a patient with subcutaneous fat necrosis
- Late presentation of glycogen storage disease types Ia and III in children with short stature and hepatomegaly
- A novel paraneoplastic syndrome with acquired lipodystrophy and chronic inflammatory demyelinating polyneuropathy in an adolescent male with craniopharyngioma
Articles in the same Issue
- Frontmatter
- Original Articles
- HbA1c levels in children with type 1 diabetes and correlation to diabetic retinopathy
- Relationship between urinary sodium-creatinine ratios and insulin resistance in Korean children and adolescents with obesity
- Prevalence of comorbid conditions pre-existing and diagnosed at a tertiary care pediatric weight management clinic
- The relationship between diet quality and insulin resistance in obese children: adaptation of the Healthy Lifestyle-Diet Index in Turkey
- Outcomes of mitochondrial derived diseases: a single-center experience
- Metabolic and genetic markers’ associations with elevated levels of alanine aminotransferase in adolescents
- Phenotypic presentation of adolescents with overt primary hypothyroidism
- Growth velocity and biological variables during puberty in achondroplasia
- Employing a results-based algorithm to reduce laboratory utilization in ACTH stimulation testing
- Investigating the changes in amino acid values in premature infants: a pilot study
- A hierarchical Bayesian tri-variate analysis on factors associated with anthropometric measures in a large sample of children and adolescents: the CASPIAN-IV study
- Smith-Lemli-Opitz syndrome: clinical and biochemical correlates
- Case Reports
- Sporadic pediatric papillary thyroid carcinoma harboring the ETV6/NTRK3 fusion oncogene in a 7-year-old Japanese girl: a case report and review of literature
- Hypercalcemia, hyperkalemia and supraventricular tachycardia in a patient with subcutaneous fat necrosis
- Late presentation of glycogen storage disease types Ia and III in children with short stature and hepatomegaly
- A novel paraneoplastic syndrome with acquired lipodystrophy and chronic inflammatory demyelinating polyneuropathy in an adolescent male with craniopharyngioma
