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A Japanese patient with congenital central hypothyroidism caused by a novel IGSF1 mutation

  • Takeshi Yamaguchi EMAIL logo , Tomoyuki Hothubo , Shuntaro Morikawa , Akie Nakamura , Toshihiko Mori and Toshihiro Tajima
Published/Copyright: February 9, 2018

Abstract

Background:

IGSF1 abnormality causes diverse symptoms, including congenital central hypothyroidism (CCH), prolactin hyposecretion, testicular enlargement and delayed puberty.

Case presentation:

Here, we report a case of a male patient who visited our hospital with a chief complaint of abdominal pain and short stature, in whom we identified a novel IGSF1 mutation. He was closely examined because of chronic constipation since infancy, persistent abdominal pain at 14 years of age and marked short stature (−4.7 standard deviation [SD] for normal Japanese boys). He was diagnosed with CCH. Decreased prolactin (PRL) secretion was also observed. IGSF1 analysis revealed a novel mutation at the splicing donor site (c.2065+1G>A) in intron 11. In silico analysis predicted this mutation to be a non-functional splice donor site. After thyroid hormone replacement, his thyroid function, constipation and growth rate improved.

Conclusions:

This is the first report of a patient in whom constipation and short stature led to a diagnosis of CCH with a novel IGSF1 mutation.


Corresponding author: Takeshi Yamaguchi, MD, Department of Pediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-0835, Japan, Phone: +81-11-706-5954, Fax: +81-11-706-7898

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2017-4-14
Accepted: 2017-11-28
Published Online: 2018-2-9
Published in Print: 2018-3-28

©2018 Walter de Gruyter GmbH, Berlin/Boston

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