CNDP1 genotype and renal survival in pediatric nephropathies
-
Verena Peters
,
Moustafa Kebbewar
Abstract
Background: The risk of developing type II diabetic nephropathy (DN) is lower in patients carrying the CNDP1 Mannheim polymorphism (homozygosity for the five leucine repeat), resulting in decreased activity of the histidine-dipeptide metabolizing enzyme carnosinase. The role of CNDP1 in other nephropathies is still unknown.
Methods: To evaluate the impact of the CNDP1 Mannheim allele on pediatric chronic kidney disease (CKD), we prospectively followed the long-term clinical outcome of 272 children with non-diabetic kidney disease (glomerulopathies n=32, non-glomerular kidney disease n=240).
Results: Renal failure progression was independent of CNDP1 genotype in the total cohort of CKD children. However, in patients with glomerulopathies, only 39% of patients homozygous for the CNDP1 Mannheim polymorphism attained the primary renal endpoint as compared to 77% of patients with any other CNDP1 genotype (p=0.06).
Conclusions: Our findings in pediatric CKD patients suggest that the nephroprotective effect of the CNDP1 Mannheim variant is not restricted to patients with diabetic nephropathy.
Acknowledgments
We thank Kristina Klingbeil for excellent technical assistance.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: The ESCAPE trial was supported by grants of the Boehringer Ingelheim Stiftung, the European Commission (5th Framework Program QLRT-2001-00908, the Kuratorium für Dialyse und Nierentransplantation e.V., Neu-Isenburg, and the Baxter Extramural Grant Program. Part of this study was supported by grants of the Deutsche Forschungsgemeinschaft (SFB 1118) and the Doktor Pfleger Foundation, Bamberg, Germany.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
Appendix
Investigators participating in the ESCAPE Trial:
A. Anarat. Cukurova University School of Medicine, Balcali, Adana, Turkey. A. Bakkaloglu, F. Ozaltin. Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey. A. Peco-Antic. University Children’s Hospital, Belgrade, Serbia. U. Querfeld, J. Gellermann, Charité Children’s Hospital, Berlin, Germany. P. Sallay. Semmelweis University Budapest, 1st Dept. of Pediatrics, Budapest, Hungary. D. Drożdż. Polish-American Children’s Hospital, Jagiellonian University, Krakow, Poland. K.-E. Bonzel, A.-M. Wingen. University Hospital Essen, Germany. A. Żurowska, I. Balasz, Dpt. of Paediatric and Adolescent Nephrology and Hypertension, Medical University Gdansk, Poland. A.Trivelli, F. Perfumo. G. Gaslini Institute, Genova, Italy. D.E. Müller-Wiefel, K. Möller. University Children’s Hospital Hamburg, Germany. G. Offner, B. Enke. Children’s Hospital, Hannover Medical School, Germany. E. Wühl, C. Gimpel, O. Mehls, F. Schaefer. Center for Pediatrics and Adolescent Medicine, Heidelberg, Germany. S. Emre. Istanbul University Medical Faculty, Capa, Istanbul, Turkey. S. Caliskan. Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey. S. Mir. Dept. of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkey. S. Wygoda. St. Georg Hospital, Leipzig, Germany. K. Hohbach-Hohenfellner. University Children’s Hospital, Mainz, Germany. N. Jeck, G. Klaus. Dept. of Pediatrics, Philipp University Marburg, Germany. G. Ardissino, S. Testa. IRCCS Ospedale Maggiore, Policlinico-Mangiagalli, Milano, Italy. G. Montini. Azienda Ospedaliera-Università di Padova, Padova, Italy. M. Charbit, P. Niaudet. Hopital Necker, Paris, France. A. Caldas-Afonso, A. Fernandes-Teixeira. Hospital S. Joao, Porto, Portugal. J. Dušek. University Hospital Motol, Dpt. of Pediatrics, Prague, Czech Republic. M.C. Matteucci, S. Picca, A. Mastrostefano. Ospedale Pediatrico Bambino Gesù, Rome, Italy. M. Wigger. University Children’s Hospital, Rostock, Germany. U.B. Berg, G. Celsi. Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden. M. Fischbach, J. Terzic. Hopitaux Universitaires de Strasbourg, Pediatrie 1, Strasbourg, France. J. Fydryk, T. Urasinski. Pomeranian Academy of Medicine, Szczecin, Poland. R. Coppo, Licia Peruzzi. Ospedale Infantile Regina Margherita, Torino, Italy. K. Arbeiter. University Children’s Hospital, Vienna, Austria. A. Jankauskiené. Children’s Hospital, University of Vilnius, Lithuania. R. Grenda, M. Litwin, R. Janas. Children’s Memorial Health Hospital, Warsaw, Poland. T.J. Neuhaus, G. Laube. University Children’s Hospital, Zürich, Switzerland.
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©2016 by De Gruyter
Articles in the same Issue
- Frontmatter
- Original Articles
- Translation and psychometric properties of the Persian version of self-management of type 1 diabetes for adolescents
- Generic and disease-specific quality of life in adolescents with type 1 diabetes: comparison to age-matched healthy peers
- Relationship between HOMA-IR and serum vitamin D in Chinese children and adolescents
- Low 25-hydroxyvitamin D level is not an independent risk factor for hepatosteatosis in obese children
- Pediatric thyroid nodules: ultrasonographic characteristics and inter-observer variability in prediction of malignancy
- Frequency of thyroid status monitoring in the first year of life and predictors for more frequent monitoring in infants with congenital hypothyroidism
- Biochemical, radiological, and genetic characterization of congenital hypothyroidism in Abu Dhabi, United Arab Emirates
- High prevalence of DUOX2 mutations in Japanese patients with permanent congenital hypothyroidism or transient hypothyroidism
- Children with severe Osteogenesis imperfecta and short stature present on average with normal IGF-I and IGFBP-3 levels
- Association between physical activity and bone in children with Prader-Willi syndrome
- CNDP1 genotype and renal survival in pediatric nephropathies
- 17-Hydroxyprogesterone responses to human chorionic gonadotropin are not associated with serum anti-Mullerian hormone levels among adolescent girls with polycystic ovary syndrome
- Near-final height in 82 Chinese patients with congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency: a single-center study from China
- Case Reports
- Sertoli cell only syndrome with ambiguous genitalia
- Childhood parathyroid adenoma: a rare but important cause of nephrolithiasis
- A unique case of growth hormone and human chorionic gonadotropin treatment in a 45,X male with Y: autosome translocation and literature review
- Propionic acidemia: a Turkish case report of a successful pregnancy, labor and lactation
- Unusual phenotype of congenital adrenal hyperplasia (CAH) with a novel mutation of the CYP21A2 gene
- Central diabetes insipidus as a very late relapse limited to the pituitary stalk in Langerhans cell histiocytosis
Articles in the same Issue
- Frontmatter
- Original Articles
- Translation and psychometric properties of the Persian version of self-management of type 1 diabetes for adolescents
- Generic and disease-specific quality of life in adolescents with type 1 diabetes: comparison to age-matched healthy peers
- Relationship between HOMA-IR and serum vitamin D in Chinese children and adolescents
- Low 25-hydroxyvitamin D level is not an independent risk factor for hepatosteatosis in obese children
- Pediatric thyroid nodules: ultrasonographic characteristics and inter-observer variability in prediction of malignancy
- Frequency of thyroid status monitoring in the first year of life and predictors for more frequent monitoring in infants with congenital hypothyroidism
- Biochemical, radiological, and genetic characterization of congenital hypothyroidism in Abu Dhabi, United Arab Emirates
- High prevalence of DUOX2 mutations in Japanese patients with permanent congenital hypothyroidism or transient hypothyroidism
- Children with severe Osteogenesis imperfecta and short stature present on average with normal IGF-I and IGFBP-3 levels
- Association between physical activity and bone in children with Prader-Willi syndrome
- CNDP1 genotype and renal survival in pediatric nephropathies
- 17-Hydroxyprogesterone responses to human chorionic gonadotropin are not associated with serum anti-Mullerian hormone levels among adolescent girls with polycystic ovary syndrome
- Near-final height in 82 Chinese patients with congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency: a single-center study from China
- Case Reports
- Sertoli cell only syndrome with ambiguous genitalia
- Childhood parathyroid adenoma: a rare but important cause of nephrolithiasis
- A unique case of growth hormone and human chorionic gonadotropin treatment in a 45,X male with Y: autosome translocation and literature review
- Propionic acidemia: a Turkish case report of a successful pregnancy, labor and lactation
- Unusual phenotype of congenital adrenal hyperplasia (CAH) with a novel mutation of the CYP21A2 gene
- Central diabetes insipidus as a very late relapse limited to the pituitary stalk in Langerhans cell histiocytosis
