Efficacy and safety of a single monthly dose of cholecalciferol in healthy school children
-
Mohammad Shafi Kuchay
,
Ganesh Sudhakar Jevalikar
Abstract
Background: This study aimed to evaluate the efficacy and safety of a single monthly dose of cholecalciferol in healthy school children.
Methods: A total of 118 children of class VI of a residential school were selected to receive vitamin D supplementation in the form of oral cholecalciferol 60,000 IU monthly. Serum calcium and 25-hydroxyvitamin D (25OHD) levels were estimated at 0 and 12 months. The proportion of subjects achieving vitamin D sufficiency was assessed.
Results: The mean 25OHD levels increased significantly from 12.04±5.27 ng/mL at baseline to 32.6±7.05 ng/mL after 12 months of supplementation (p<0.001). None developed hypercalcemia.
Conclusions: Vitamin D supplementation in the doses of 60,000 IU monthly is a reasonable, safe and cost-effective regimen for children to attain and maintain vitamin D sufficiency.
Acknowledgments
I acknowledge the help of Ms. Neelam Sharma and the management, staff and students of Vidygyan School, Bulandshahr, Uttar Pradesh, India who helped in conducting the study. I also thank Mr. Manish K Singh who helped in carrying out the statistical analysis.
Contributions: MSK, GSJ and AM: design of the study, collection and analysis of data, and writing of the manuscript; SKM: collection and analysis of data; DN: laboratory work
Funding: None
Competing interests: None
References
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©2016 by De Gruyter
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Articles in the same Issue
- Frontmatter
- Highlight: Vitamin D in Health and Disease
- Vitamin D in health and disease: the global threat of vitamin D deficient rickets
- Effect of 6-months’ vitamin D supplementation on residual beta cell function in children with type 1 diabetes: a case control interventional study
- Low serum sclerostin levels in newborns with vitamin D deficiency
- Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy
- Efficacy and safety of a single monthly dose of cholecalciferol in healthy school children
- Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys
- It’s high time to revise Indian guidelines on vitamin D supplementation in children
- Review
- Slipped capital femoral epiphysis and associated hypothyroidism. A review of the literature with two classic case examples
- Original Articles
- Relationship between oxidative stress and blood glucose fluctuations evaluated with daily glucose monitoring in children with type 1 diabetes mellitus
- Association between circulating CCL2 levels and modifiable behaviors in overweight and obese adolescents: a cross-sectional pilot study
- Evaluating health risk using a continuous metabolic syndrome score in obese children
- The association of thyroid hormones and blood pressure in euthyroid preadolescents
- Growth failure in adolescents: etiology, the role of pubertal timing and most useful criteria for diagnostic workup
- New approach to phenotypic variability and karyotype-phenotype correlation in Turner syndrome
- Clinical findings and effect of sodium hydrogen carbonate in patients with glutathione synthetase deficiency
- Maturity onset diabetes of youth (MODY) in Turkish children: sequence analysis of 11 causative genes by next generation sequencing
- Case Reports
- Long-term first line medical treatment in a 4-year-old girl with Xq26.3 microduplication-negative somatotropinoma. Case report and literature review
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