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The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

  • Anna S. Challa EMAIL logo , Stefania E. Makariou and Ekaterini C. Siomou
Published/Copyright: June 6, 2015
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 28 Issue 11-12

Abstract

Among children and adolescents, metabolic syndrome (MetS) is more common than previously believed. Hence, any information on the relation between vitamin D insufficiency/deficiency and insulin resistance (IR) in this population with risk of developing MetS is of great importance. This review analyzes and evaluates the existing evidence from cross-sectional, observational, and retrospective studies concerning the effect of vitamin D insufficiency/deficiency on MetS as a whole or on its various components. Most data show that insufficient vitamin D status is associated with increased prevalence of MetS or its individual components, mainly blood pressure and IR, often independent of overall obesity or abdominal adiposity. The implications of these findings could be associated with increased risk for developing cardiovascular disease and type 2 diabetes mellitus in later life. The very few randomized control trials examining any possible beneficial effects of vitamin D supplementation are also included.

Keywords: insulin resistance/sensitivity; metabolic syndrome; vitamin D insufficiency/deficiency
Corresponding author: Anna S. Challa, Child Health Research Laboratory, Medical School, University of Ioannina, Ioannina, 451 10, Greece, Phone: +302651009271, Fax: +302651007882, E-mail:

References

1. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the Third National Health and Nutrition Examination Survey, 1988–1994. Arch Pediatr Adolesc Med 2003;157:821–7.10.1001/archpedi.157.8.821Search in Google Scholar PubMed

2. Strauss RS, Pollack HA. Epidemic increase in childhood overweight, 1986–1998. J Am Med Assoc 2001;286:2845–8.10.1001/jama.286.22.2845Search in Google Scholar PubMed

3. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004;350:2362–74.10.1056/NEJMoa031049Search in Google Scholar PubMed

4. Zimmet P, Alberti G, Kaufman F, Tajima N, Silink M, et al. The metabolic syndrome in children and adolescents: an IDF consensus report. Pediatr Diab 2007;8:299–306.10.1111/j.1399-5448.2007.00271.xSearch in Google Scholar PubMed

5. Lee S, Bacha F, Gungor N, Arslanian SA. Waist circumference is an independent predictor of insulin resistance in black and white youths. J Pediatr 2006;148:188–94.10.1016/j.jpeds.2005.10.001Search in Google Scholar PubMed

6. Klag MJ, Ford DE, Mead LA, He J, Whelton PK, et al. Serum cholesterol in young men and subsequent cardiovascular disease. N Engl J Med 1993;328:313–8.10.1056/NEJM199302043280504Search in Google Scholar PubMed

7. Körner A, Kratzsch J, Gausche R, Schaab M, Erbs S, et al. New predictors of the metabolic syndrome in children – role of adipocytokines. Pediatr Res 2007;61:640–5.10.1203/01.pdr.0000262638.48304.efSearch in Google Scholar PubMed

8. Böttner A, Kratzsch J, Müller G, Kapellen TM, Blüher S, et al. Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab 2004;89:4053–61.10.1210/jc.2004-0303Search in Google Scholar PubMed

9. Gilardini L, McTernan PG, Girola A, da Silva NF, Alberti L, et al. Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis 2006;189:401–7.10.1016/j.atherosclerosis.2005.12.021Search in Google Scholar PubMed

10. Ogawa Y, Kikuchi T, Nagasaki K, Hiura M, Tanaka Y, et al. Usefulness of serum adiponectin level as a diagnostic marker of metabolic syndrome in obese Japanese children. Hypertens Res 2005;28:51–7.10.1291/hypres.28.51Search in Google Scholar PubMed

11. Ford ES, Ajani UA, McGuire LC, Liu S. Concentrations of serum vitamin D and the metabolic syndrome among US. adults. Diabetes Care 2005;28:1228–30.10.2337/diacare.28.5.1228Search in Google Scholar

12. Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr 2005;94:483–92.10.1079/BJN20051544Search in Google Scholar

13. Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, et al. Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus. Diabetes Res Clin Pract 1995;27:181–8.10.1016/0168-8227(95)01040-KSearch in Google Scholar

14. Hyppönen E, Power C. Vitamin D status and glucose homeostasis in the 1958 British birth cohort; the role of obesity. Diabetes Care 2006;29:2244–6.10.2337/dc06-0946Search in Google Scholar

15. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and β-cell dysfunction. Am J Clin Nutr 2004;79:820–5.10.1093/ajcn/79.5.820Search in Google Scholar

16. Mathieu C, Gysemans C, Giulietti A, Bouillon R. Vitamin D and diabetes. Diabetologia 2005;48:1247–57.10.1007/s00125-005-1802-7Search in Google Scholar

17. Reaven GM. Banting Lecture 1988: role of insulin resistance in human disease. Diabetes 1988;37:1595–607.10.2337/diab.37.12.1595Search in Google Scholar

18. Levitt NS, Lambert EV. The foetal origins of the metabolic syndrome – a South African perspective. Cardiovasc J S Afr 2002;13:179–80.Search in Google Scholar

19. Ozanne SE, Hales CN. Early programming of glucose-insulin metabolism. Trends Endocrinol Metab 2002;13:368–73.10.1016/S1043-2760(02)00666-5Search in Google Scholar

20. Ford ES, Ajani UA, Mokdad AH. National Health and Nutrition Examination. The metabolic syndrome and concentrations of C-reactive protein among US youth. Diabetes Care 2005;28:878–81.10.2337/diacare.28.4.878Search in Google Scholar

21. Bao W, Threefoot SA, Srinivasan SR, Berenson GS. Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa Heart Study. Am J Hypertens 1995;8:657–65.10.1016/0895-7061(95)00116-7Search in Google Scholar

22. Cook NR, Cohen J, Hebert PR, Taylor JO, Hennekens CH. Implications of small reductions in diastolic blood pressure for primary prevention. Arch Intern Med 1995;155:701–9.10.1001/archinte.1995.00430070053006Search in Google Scholar

23. Reis JP, von Mühlen D, Miller ER III, Michos ED, Appel LJ. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics 2009;124:e371–9.10.1542/peds.2009-0213Search in Google Scholar PubMed PubMed Central

24. Ganji V, Zhang X, Shaikh N, Tangpricha V. Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25 hydroxyvitamin D data from NHANES 2001–2006. Am J Clin Nutr 2011;94:225–33.10.3945/ajcn.111.013516Search in Google Scholar PubMed

25. Williams DM, Fraser A, Lawlor DA. Associations of vitamin D, parathyroid hormone and calcium with cardiovascular risk factors in US adolescents. Heart 2011;97:315–20.10.1136/hrt.2010.203224Search in Google Scholar PubMed PubMed Central

26. Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML. Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001–2004. Pediatrics 2009;124:e362–70.10.1542/peds.2009-0051Search in Google Scholar PubMed PubMed Central

27. Pacifico L, Anania C, Osborn JF, Ferraro F, Bonci E, et al. Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents. Eur J Endocrinol 2011;165:603–11.10.1530/EJE-11-0545Search in Google Scholar PubMed

28. Nsiah-Kumi PA, Erickson JM, Beals EA, Whiting M, Brushbreaker C, et al. Vitamin D insufficiency is associated with diabetes risk in Native American children. Clin Pediatr 2012;51:146–53.10.1177/0009922811417290Search in Google Scholar PubMed

29. Nam GE, Kim DH, Cho KH, Park YG, Han KD, et al. 25-Hydroxyvitamin D insufficiency is associated with cardiometabolic risk in Korean adolescents: the 2008–2009 Korea National Health and Nutrition Examination Survey (KNHANES). Public Health Nutr 2012;17:186–94.10.1017/S1368980012004855Search in Google Scholar PubMed

30. Alfawaz HA, Abdel Megeid FY. Vitamin D deficiency in obese children and its relationship to the components of the metabolic syndrome. World Appl Sci J 2013;21:320–8.Search in Google Scholar

31. Smotkin-Tangorra M, Purushothaman R, Gupta A, Nejati G, Anhalt H, et al. Prevalence of vitamin D insufficiency in obese children and adolescents. J Pediatr Endocrinol Metab 2007;20:817–23.10.1515/JPEM.2007.20.7.817Search in Google Scholar PubMed

32. Zhou P, Schechter C, Ziyong Cai Z, Markowitz M. Determinants of 25(OH)D sufficiency in obese minority children: selecting outcome measures and analytic approaches. J Pediatr 2011;158:930–4.10.1016/j.jpeds.2010.11.034Search in Google Scholar PubMed

33. Garanty-Bogacka B, Syrenicz M, Goral J, Krupa B, Syrenicz J, et al. Serum 25-hydroxyvitamin D (25-OH-D) in obese adolescents. Pol J Endocrinol 2011;62:506–11.Search in Google Scholar

34. Buyukinan M, Ozen S, Kokkun S, Eylem Ulas Saz EU. The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents. J Pediatr Endocr Met 2012;25:83–7.10.1515/jpem-2011-0426Search in Google Scholar PubMed

35. Al-Daghri NM, Al-Attas OS, Alokail MS, Khalid M, Alkharfy KM, et al. Hypovitaminosis D and cardiometabolic risk factors among non-obese youth. Cent Eur J Med 2010;5:752–7.10.2478/s11536-010-0045-2Search in Google Scholar

36. Rodríguez-Rodríguez E, Ortega RM, González-Rodríguez LG, López-Sobaler AM. Vitamin D deficiency is an independent predictor of elevated triglycerides in Spanish school children. Eur J Nutr 2011;50:373–8.10.1007/s00394-010-0145-4Search in Google Scholar PubMed

37. Parikh S, Guo De-H, Pollok NK, Petty K, Bhagatwala J, et al. Circulating 25-hydroxyvitamin D concentrations are correlated with cardiometabolic risk among American Black and White adolescents living in a year-round sunny climate. Diabetes Care 2012;35:1133–8.10.2337/dc11-1944Search in Google Scholar PubMed PubMed Central

38. Kelishadi R, Ardalan G, Motlagh EM, Shariatinejad K, Heshmat R, et al. National report on the association of serum vitamin D with cardiometabolic risk factors in the pediatric population of the Middle East and North Africa (MENA): the CASPIAN-III Study. Nutrition 2014;30:33–8.10.1016/j.nut.2013.05.018Search in Google Scholar PubMed

39. Olson ML, Maalouf NM, Oden JD, White PC, Hutchison MR. Vitamin D deficiency in obese children and its relationship to glucose homeostasis. J Clin Endocrinol Metab 2012;97:279–85.10.1210/jc.2011-1507Search in Google Scholar PubMed PubMed Central

40. Williams DM, Fraser A, Sayers A, Fraser WD, Hingorani A, et al. Associations of 25-hydroxyvitamin D2 and D3 with cardiovascular risk factors in childhood: cross-sectional findings from the Avon Longitudinal Study of Parents and Children. J Clin Endocrinol Metab 2012;97:1563–71.10.1210/jc.2011-2335Search in Google Scholar PubMed PubMed Central

41. Lee SH, Kim SM, Park HS, Choi KM, Cho GJ, et al. Serum 25-hydroxyvitamin D levels, obesity and the metabolic syndrome among Korean children. Nutr Metab Cardiovasc Dis 2013;23:785–91.10.1016/j.numecd.2012.04.013Search in Google Scholar PubMed

42. Williams DM, Fraser A, Sayers A, Fraser WD, Hyppönen E, et al. Associations of childhood 25-hydroxyvitamin D2 and D3 and cardiovascular risk factors in adolescence prospective findings from the Avon Longitudinal Study of Parents and Children. Eur J Prev Cardiol 2014;21:281–90.10.1177/2047487312465688Search in Google Scholar PubMed PubMed Central

43. Alemzadeh R, Kichler J, Babar G, Calhoun M. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism 2008;57:183–91.10.1016/j.metabol.2007.08.023Search in Google Scholar PubMed

44. Ashraf A, Alvarez J, Saenz K, Gower B, McCormick K, et al. Threshold for effects of vitamin D deficiency on glucose metabolism in obese female African–American adolescents. J Clin Endocrinol Metab 2009;94:3200–6.10.1210/jc.2009-0445Search in Google Scholar PubMed PubMed Central

45. Delvin EE, Lambert M, Levy E, O’Loughlin J, Mark S, et al. Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents. J Nutr 2010;140:987–91.10.3945/jn.109.112250Search in Google Scholar PubMed

46. Johnson MD, Nader NS, Weaver AL, Singh R, Kumar S. Relationships between 25-Hydroxyvitamin D levels and plasma glucose and lipid levels in pediatric outpatients. J Pediatr 2010;156:444–9.10.1016/j.jpeds.2009.09.070Search in Google Scholar PubMed

47. Ford ES, Zhao G, Tsai J, Li C. Associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA1c among adolescents in the United States. Diabetes Care 2011;34:646–8.10.2337/dc10-1754Search in Google Scholar PubMed PubMed Central

48. Kelly A, Brooks LJ, Dougherty S, Carlow DC, Zemel BS. A cross-sectional study of vitamin D and insulin resistance in children. Arch Dis Child 2011;96:447–52.10.1136/adc.2010.187591Search in Google Scholar PubMed

49. Roth CL, Elfers C, Kratz M, Hoofnagle AN. Vitamin D deficiency in obese children and its relationship to insulin resistance and adipokines. J Obes 2011;2011:Article ID 495101.10.1155/2011/495101Search in Google Scholar PubMed PubMed Central

50. Hirschler V, MacCalinni G, Gilligan T, Gonzalez C, Claudia M, et al. Association of vitamin D with insulin resistance in Argentine boys: a pilot study. J Ped Biochem 2012;2:91–9.Search in Google Scholar

51. Ha CD, Cho J-K, Lee SH, Kang HS. Serum vitamin D, physical activity and metabolic risk factors in Korean children. Med Sci Sports Exerc 2013;45:102–8.10.1249/MSS.0b013e31826c6956Search in Google Scholar PubMed

52. Rajakumar K, de Las Heras J, Lee S, Holick MF, Arslanian SA. 25-Hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth. Diabetes Care 2012;35:627–33.10.2337/dc11-1825Search in Google Scholar PubMed PubMed Central

53. Khadgawat R, Thomas T, Gahlot M, Tandon N, Tangpricha V, et al. The effect of puberty on interaction between vitamin D status and insulin resistance in obese Asian-Indian children. Intl J Endocrinol 2012;2012:Article no. 173581.10.1155/2012/173581Search in Google Scholar PubMed PubMed Central

54. Erdonmez D, Hatun S, Cizmecioğlu FM, Keser A. No relationship between vitamin D status and insulin resistance in a group of high school students. J Clin Res Pediatr Endocrinol 2011;3: 198–201.10.4274/jcrpe.507Search in Google Scholar PubMed PubMed Central

55. Poomthavorn P, Saowan S, Mahachoklertwattana P, Chailurkit L, Khlairit P. Vitamin D status and glucose homeostasis in obese children and adolescents living in the tropics. Intl J Obes 2012;36:491–5.10.1038/ijo.2011.260Search in Google Scholar PubMed

56. Creo AL, Rosen JS, Ariza AJ, Hidaka KM, Binns HJ. Vitamin D levels, insulin resistance, and cardiovascular risks in very young obese children. J Pediatr Endocrinol Metab 2013;26:97–104.10.1515/jpem-2012-0244Search in Google Scholar PubMed

57. De las Heras J, Rajakumar K, Lee S, Bacha F, Holick MF, et al. 25-Hydroxyvitamin D in obese youth across the spectrum of glucose tolerance from normal to prediabetes to Type 2 diabetes. Diabetes Care 2013;36:2048–53.10.2337/dc12-1288Search in Google Scholar PubMed PubMed Central

58. Torun E, Gönüllü E, Özgen İT, Cindemir E, Öktem F. Vitamin D deficiency and insufficiency in obese children and adolescents and its relationship with insulin resistance. Intl J Endocrinol 2013: Article ID 631845.10.1155/2013/631845Search in Google Scholar PubMed PubMed Central

59. Sacheck J, Elizabeth E, Chui K, Chomitz V, Must A, et al. Vitamin D deficiency, adiposity, and cardiometabolic risk in urban schoolchildren. J Pediatr 2011;159:945–50.10.1016/j.jpeds.2011.06.001Search in Google Scholar PubMed PubMed Central

60. Graham D, Kiras G, Conaglen J, McLennan S, Rush E. Vitamin D status of year 3 children and supplementation through schools with fortified milk. Public Health Nutr 2008;12:2329–34.10.1017/S1368980008004357Search in Google Scholar PubMed

61. Ashraf AP, Alvarez JA, Gower BA, Saenz KH, McCormick KL. Associations of serum 25-hydroxyvitamin D and components of the metabolic syndrome in obese adolescent females. Obesity 2011;19:2214–21.10.1038/oby.2011.110Search in Google Scholar PubMed PubMed Central

62. Belenchia AM, Tosh AK, Hillman LS, Petersen CA. Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr 2013;97:774–81.10.3945/ajcn.112.050013Search in Google Scholar PubMed

63. Kelishadi R, Salek S, Salek M, Hashemipour M, Movahedian M. Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: a triple-masked controlled trial. J Pediatr (Rio J) 2014;90:28–34.10.1016/j.jped.2013.06.006Search in Google Scholar PubMed

64. Kelishadi R, Farajzadegan Z, Bahreynian M. Association between vitamin D status and lipid profile in children and adolescents: a systematic review and meta-analysis. Int J Food Sci Nutr 2014;65:404–10.10.3109/09637486.2014.886186Search in Google Scholar PubMed

65. Newton AL, Hanks LJ, Ashraf AP, Williams E, Davis M, et al. Macronutrient intake influences the effect of 25-hydroxy-vitamin D status on metabolic syndrome outcomes in African American girls. Cholesterol 2012; 2012:Article ID 581432.10.1155/2012/581432Search in Google Scholar PubMed PubMed Central

66. Dong Y, Stallman-Jorgensen IS, Pollock NK, Harris RA, Keeton D, et al. A 16-week randomized clinical trial of 2000 International Units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness. J Clin Endocrinol Metab 2010;95:4584–91.10.1210/jc.2010-0606Search in Google Scholar PubMed

67. Wehr E, Pieber TR, Obermayer-Pietsch B. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a pilot study. J Endocrinol Invest 2011;34:757–63.Search in Google Scholar

68. Wu SH, Ho SC, Liu Z. Effects of vitamin D supplementation on blood pressure. South Med J 2010;103:729–37.10.1097/SMJ.0b013e3181e6d389Search in Google Scholar PubMed

69. Von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient-a randomised, placebo-controlled trial. Br J Nutr 2010;103:549–55.10.1017/S0007114509992017Search in Google Scholar PubMed

70. Nunlee-Bland G, Gambhir K, Abrams C, Abdul M, Vahedi M, et al. Vitamin D deficiency and insulin resistance in obese African-American adolescents. J Pediatr Endocr Metab 2011;24:29–33.10.1515/jpem.2011.107Search in Google Scholar PubMed PubMed Central

71. Willheim M, Thien R, Schrattbauer K, Bajna E, Holub M, et al. Regulatory effects of 1 alpha, 25 dihydroxyvitamin D3 on cytokine production of human peripheral blood lymphocytes. J Clin Endocrinol Metab 1999;84:3739–44.Search in Google Scholar

72. Dahlquist G, Patterson C, Soltesz G. Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group. Diabetologia 1999;42:51–4.Search in Google Scholar

Received: 2014-11-28
Accepted: 2015-5-4
Published Online: 2015-6-6
Published in Print: 2015-11-1

©2015 by De Gruyter

Articles in the same Issue

  1. Frontmatter
  2. Highlight: Turner syndrome
  3. Turner syndrome – working together with patients and their families
  4. Turner syndrome patients with bicuspid aortic valves and renal malformations exhibit abnormal expression of X-linked inhibitor of apoptosis protein (XIAP)
  5. Inhibin B in adolescents and young adults with Turner syndrome
  6. Mode of initial presentation and chromosomal abnormalities in Irish patients with Turner syndrome: a single-centre experience
  7. Retrospective evaluation of pubertal development and linear growth of girls with Turner Syndrome treated with oral and transdermal estrogen
  8. Turner syndrome in Albania and the efficacy of its treatment with growth hormone
  9. Review articles
  10. The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update
  11. Putting the pieces together: cryptorchidism – do we know everything?
  12. Original articles
  13. Investigation of androgen receptor gene mutations in a series of 21 patients with 46,XY disorders of sex development
  14. Molecular diagnosis of maturity-onset diabetes of the young (MODY) in Turkish children by using targeted next-generation sequencing
  15. Association of physical activity level with depression, anxiety, and quality of life in children with type 1 diabetes mellitus
  16. Neonatal diabetes in Ukraine: incidence, genetics, clinical phenotype and treatment
  17. The effect of intraoperative administration of dexamethasone for PONV prophylaxis on perioperative blood glucose level in obese and normal weight children
  18. Are obesity and metabolic syndrome associated with plasma adropin levels in children?
  19. Carnitine insufficiency in children with inborn errors of metabolism: prevalence and treatment efficacy
  20. Comparison of energy expenditure, body composition, metabolic disorders, and energy intake between obese children with a history of craniopharyngioma and children with multifactorial obesity
  21. Effect of serum cholesterol on bone mineral density in normal-weight children and adolescents
  22. Assessment of bone turnover markers and bone mineral density in normal short boys
  23. Long-term treatment for hyperphenylalaninemia and phenylketonuria: a risk for nutritional vitamin B12 deficiency?
  24. Risk factors affecting the development of nephrocalcinosis, the most common complication of hypophosphatemic rickets
  25. Children with hyperthyroidism younger than age 7 require higher mg/kg doses of methimazole to normalize free T4 compared to older children
  26. Effects of bisphosphonates to treat osteoporosis in children with cerebral palsy: a meta-analysis
  27. AMH levels at central precocious puberty and premature thelarche: is it a parameter?
  28. Validating Paediatric Morphometrics: body proportion measurement using photogrammetric anthropometry
  29. Treatment of central precocious puberty and early puberty with GnRH analog in girls with Williams-Beuren syndrome
  30. Short communication
  31. Pilot study on the dietary habits and lifestyles of girls with idiopathic precocious puberty from the city of Rome: potential impact of exposure to flame retardant polybrominated diphenyl ethers
  32. Patient reports
  33. Hypomagnesemia due to two novel TRPM6 mutations
  34. A novel mutation of AMH in three siblings with persistent Mullerian duct syndrome
  35. Kocher-Debré-Semelaigne syndrome with rhabdomyolysis and increased creatinine
  36. Anaphylaxis to gonadorelin acetate in a girl with central precocious puberty
  37. Efficacy and safety of sirolimus in a neonate with persistent hypoglycaemia following near-total pancreatectomy for hyperinsulinaemic hypoglycaemia
https://doi.org/10.1515/jpem-2014-0485
Keywords for this article
insulin resistance/sensitivity; metabolic syndrome; vitamin D insufficiency/deficiency

Articles in the same Issue

  1. Frontmatter
  2. Highlight: Turner syndrome
  3. Turner syndrome – working together with patients and their families
  4. Turner syndrome patients with bicuspid aortic valves and renal malformations exhibit abnormal expression of X-linked inhibitor of apoptosis protein (XIAP)
  5. Inhibin B in adolescents and young adults with Turner syndrome
  6. Mode of initial presentation and chromosomal abnormalities in Irish patients with Turner syndrome: a single-centre experience
  7. Retrospective evaluation of pubertal development and linear growth of girls with Turner Syndrome treated with oral and transdermal estrogen
  8. Turner syndrome in Albania and the efficacy of its treatment with growth hormone
  9. Review articles
  10. The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update
  11. Putting the pieces together: cryptorchidism – do we know everything?
  12. Original articles
  13. Investigation of androgen receptor gene mutations in a series of 21 patients with 46,XY disorders of sex development
  14. Molecular diagnosis of maturity-onset diabetes of the young (MODY) in Turkish children by using targeted next-generation sequencing
  15. Association of physical activity level with depression, anxiety, and quality of life in children with type 1 diabetes mellitus
  16. Neonatal diabetes in Ukraine: incidence, genetics, clinical phenotype and treatment
  17. The effect of intraoperative administration of dexamethasone for PONV prophylaxis on perioperative blood glucose level in obese and normal weight children
  18. Are obesity and metabolic syndrome associated with plasma adropin levels in children?
  19. Carnitine insufficiency in children with inborn errors of metabolism: prevalence and treatment efficacy
  20. Comparison of energy expenditure, body composition, metabolic disorders, and energy intake between obese children with a history of craniopharyngioma and children with multifactorial obesity
  21. Effect of serum cholesterol on bone mineral density in normal-weight children and adolescents
  22. Assessment of bone turnover markers and bone mineral density in normal short boys
  23. Long-term treatment for hyperphenylalaninemia and phenylketonuria: a risk for nutritional vitamin B12 deficiency?
  24. Risk factors affecting the development of nephrocalcinosis, the most common complication of hypophosphatemic rickets
  25. Children with hyperthyroidism younger than age 7 require higher mg/kg doses of methimazole to normalize free T4 compared to older children
  26. Effects of bisphosphonates to treat osteoporosis in children with cerebral palsy: a meta-analysis
  27. AMH levels at central precocious puberty and premature thelarche: is it a parameter?
  28. Validating Paediatric Morphometrics: body proportion measurement using photogrammetric anthropometry
  29. Treatment of central precocious puberty and early puberty with GnRH analog in girls with Williams-Beuren syndrome
  30. Short communication
  31. Pilot study on the dietary habits and lifestyles of girls with idiopathic precocious puberty from the city of Rome: potential impact of exposure to flame retardant polybrominated diphenyl ethers
  32. Patient reports
  33. Hypomagnesemia due to two novel TRPM6 mutations
  34. A novel mutation of AMH in three siblings with persistent Mullerian duct syndrome
  35. Kocher-Debré-Semelaigne syndrome with rhabdomyolysis and increased creatinine
  36. Anaphylaxis to gonadorelin acetate in a girl with central precocious puberty
  37. Efficacy and safety of sirolimus in a neonate with persistent hypoglycaemia following near-total pancreatectomy for hyperinsulinaemic hypoglycaemia
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