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Evaluation of inflammatory and oxidative biomarkers in children with well-controlled congenital hypothyroidism

  • Ya-Li Qiu , Hong Zhu , Shao-Gang Ma EMAIL logo , Hong Liu , Qing Li and Chun-Mei Ji
Published/Copyright: April 16, 2015

Abstract

Objective: To investigate well-controlled congenital hypothyroidism on the markers associated with early kidney injury and oxidative DNA damage.

Methods: Twenty-three children with euthyroid congenital hypothyroidism aged 3–6 years and 19 age- and gender-matched controls were enrolled. Serum levels of albumin, C-reactive protein, cysteine C, globulin, pre-albumin, and total protein were detected. Urine levels of albumin, fibrin degradation products, IgG, β2-microglobulin, and 8-hydroxydeoxyguanosine (8-OHdG) were also measured. Clinical and biochemical characteristics were evaluated between the two groups.

Results: Serum levels of C-reactive protein were higher, but pre-albumin was lower in patients with congenital hyperthyroidism compared with the controls (all p<0.001). Urinary levels of IgG were higher in patients with congenital hyperthyroidism than in the controls (p=0.011). However, urinary levels of albumin excretion and 8-OHdG were similar to those in the controls. Serum pre-albumin levels were negatively correlated with urinary 8-OHdG levels (r=−0.479, p=0.016) in patients with congenital hypothyroidism.

Conclusion: It is concluded that inflammatory and oxidative markers were slightly altered in well-controlled congenital hypothyroidism. The levels of urinary 8-OHdG and albumin excretion were not significantly different.


Corresponding author: Dr. Shao-Gang Ma, PhD, MD, Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital, No. 62 Huaihai Road South, Huai’an 223002, China, Phone: +86-517-8394-3591, Fax: +86-517-8087-1820, E-mail:

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Received: 2014-10-12
Accepted: 2015-3-6
Published Online: 2015-4-16
Published in Print: 2015-7-1

©2015 by De Gruyter

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