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Virilizing adrenal oncocytoma in a 9-year-old girl: rare neoplasm with an intriguing postoperative course

  • Galina Yordanova EMAIL logo , Violeta Iotova , Kalin Kalchev , Krasimir Ivanov , Boyan Balev , Nikola Kolev , Anton Tonev and Wolter Oosterhuis
Published/Copyright: December 16, 2014

Abstract

Adrenal oncocytoma is an extremely rare neoplasm, which is mostly non-functional. Only five cases of childhood adrenal oncocytoma have been described so far, all of which were hormonally active. Currently, guidelines for management and follow-up are not available. We report a 9-year-old girl with benign adrenal oncocytoma, presenting with severe short-term virilization. After diagnostic work-up the patient underwent laparoscopic unilateral adrenalectomy. For the first 2 weeks following surgery she suffered marked mood swings, irritability and fatigue. There were no other clinical and/or laboratory abnormalities except the rapid drop-down of androgen levels to normal values. Follow-up showed no signs of recurrence and in the absence of signs of adrenal insufficiency, we speculate that, the rapid drop of androgen levels after removal of the tumor might be the reason for the deteriorated psychoemotional condition of our patient.


Corresponding author: Galina Yordanova, Clinic of Paeditric Endocrinology, UMHAT “St. Marina”, 1 “Hr. Smirnenski” Blvd., Varna 9010, Bulgaria, Phone: +359 52 300 249, Mob: +359 889 635 895, Fax: +359 52 302 889, E-mail:

Acknowledgments

The authors sincerely thank Martine Cools and S.L.S. Drop for the advice and support in the discussions and interpretation of clinical follow-up, as well as to Aneta Dokova for proofreading the original manuscript.

Disclosure statement: The authors have nothing to disclose.

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Received: 2014-7-20
Accepted: 2014-10-22
Published Online: 2014-12-16
Published in Print: 2015-5-1

©2015 by De Gruyter

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