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Research progress on rat model of drug-induced liver injury established by nonsteroidal anti-inflammatory drug (celecoxib) and royal jelly ameliorative effect

  • Naglaa Zakaria Helmy Eleiwa ORCID logo , Hesham Ahmed M. Ismael Khalifa ORCID logo and Heba Ahmed Nazim ORCID logo EMAIL logo
Published/Copyright: January 29, 2024
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 21 Issue 2

Abstract

Objectives

NSAIDs, like celecoxib, are widely used to treat pain, fever, and inflammation, with celecoxib being particularly effective in managing arthritis symptoms and acute or chronic pain especially with its favorable gastrointestinal tolerability. The study aimed at exploring the effect of chronic administration of celecoxib on hepatic tissues in male albino rats. It also examined the royal jelly celecoxib interplay.

Methods

50 male albino rats in 5 equal groups; Group 1: received no drug. Group 2: received celecoxib (50 mg/kg/day, orally), for 30 successive days. Group 3: received celecoxib plus royal jelly (300 mg/kg/day, orally) for 30 successive days. Group 4: received celecoxib, for 30 days, then were left untreated for another 30 days. Group 5: received celecoxib plus royal jelly for 30 days, then were left untreated for another 30 days.

Results

Chronic celecoxib administration caused hepatotoxicity in male albino rats, with ameliorative effect of royal jelly. Celecoxib discontinuation significantly diminished the celecoxib-induced toxicity, and normal liver enzymes and serum protein levels were regained in the case of dual medications (celecoxib+RJ) discontinuation.

Conclusions

Long-term celecoxib administration caused hepatotoxicity, with ameliorative effects of royal jelly against celecoxib-induced oxidative and apoptotic stress. In addition, it could be concluded that royal jelly may prove a useful adjunct in patients being prescribed celecoxib.

Keywords: celecoxib; hepatic; royal jelly; drug-induced toxicity; liver
Corresponding author: Heba Ahmed Nazim, Department of Pharmacology, Faculty of Vet. Med., Zagazig University, Zagazig, Egypt; and Pharmacy Inspection, Egyptian Ministry of Health & Populations, Egyptian Drug Authority, Zagazig, 44511, Egypt, Phone: 00201009156281, E-mail:

  1. Research ethics: Zagazig University Scientific Research and Publications Ethics Committee approved the study. All steps and procedures in the study were carried out following Zagazig University Institutional Animal Care and Use Committee regulations, with approval No. ZU-IACUC/2/F/ 522 /2023. All methods were carried out in accordance with relevant guidelines and regulations. It was performed according to the recommendations of Good Clinical Practice and the Declaration of Helsinki (2013).

  2. Informed consent: Not applicable.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission. All authors the concept and design of the study; N.Z., and H.K. data acquisition; H.N. statistical analysis; N.Z., H.k., and H.N. interpreted the results; H.N. analyzed the data and drafted the manuscript. All authors critically revised the manuscript, approved the final version to be published, and agree to be accountable for all aspects of the work.

  4. Competing interests: Authors state no conflict of interest.

  5. Research funding: None declared.

  6. Data availability: The raw data can be obtained on request from the corresponding author.

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Received: 2023-12-26
Accepted: 2024-01-08
Published Online: 2024-01-29

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Concept of dementia (Nisy ā n) in Unani system of medicine and scientific validation of an important Unani pharmacopoeial preparation ‘Majoon Vaj’ for its management: a review
  4. Reporting of adverse effects of pomegranate in clinical studies: a systematic review
  5. Research Articles
  6. Possible protective anticancer effect of chloroform fraction of Iraqi Hibiscus tiliaceus L. leaves extract on diethylnitrosamine-induced hepatocarcinogenesis in male rats
  7. Ethanolic extract of Persea americana Mill. (Lauraceae) seeds induced antiestrogenic effects in young female Wistar rats
  8. Modulation by Withania somnifera of stress-induced anxiogenesis and airway inflammation in rats
  9. Effects of Berberis vulgaris fruit extract on oxidative stress status in the kidney and liver of diabetic rats
  10. Fetal protective effect of Indonesian propolis from Apis mellifera against rifampicin-pyrazinamide induced impaired pregnancy in BALB/c mice
  11. Dietary supplementation with seeds of Sesamum indicum L. (pedaliaceae) mitigates the 7,12-dimethylbenz(a)anthracene-induced breast tumor burden in rats
  12. The effect of Artemisia annua L. aqueous and methanolic extracts on insulin signaling in liver of HFD/STZ diabetic mice
  13. A preclinical study to determine the anti-epileptic effect of biotin on maximal electroshock (MES) and pentylenetetrazole (PTZ) models in albino rats
  14. Caffeic acid attenuates memory dysfunction and restores the altered activity of cholinergic, monoaminergic and purinergic in brain of cadmium chloride exposure rats
  15. Research progress on rat model of drug-induced liver injury established by nonsteroidal anti-inflammatory drug (celecoxib) and royal jelly ameliorative effect
  16. Anti-inflammatory, anti-oxidant and anti-ulcer activities of aqueous lyophilizate of Markhamia lutea (Bignoniaceae)
  17. Effects of Laghoo Shankaprakshalana (yogic colon cleansing) on anthropometric measurements in obese individuals
  18. Short Communication
  19. A short review on deciphering Vyadhikshamatva: insights from HLA-B27-ankylosing spondylitis relation
https://doi.org/10.1515/jcim-2023-0385
Keywords for this article
celecoxib; hepatic; royal jelly; drug-induced toxicity; liver

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Concept of dementia (Nisy ā n) in Unani system of medicine and scientific validation of an important Unani pharmacopoeial preparation ‘Majoon Vaj’ for its management: a review
  4. Reporting of adverse effects of pomegranate in clinical studies: a systematic review
  5. Research Articles
  6. Possible protective anticancer effect of chloroform fraction of Iraqi Hibiscus tiliaceus L. leaves extract on diethylnitrosamine-induced hepatocarcinogenesis in male rats
  7. Ethanolic extract of Persea americana Mill. (Lauraceae) seeds induced antiestrogenic effects in young female Wistar rats
  8. Modulation by Withania somnifera of stress-induced anxiogenesis and airway inflammation in rats
  9. Effects of Berberis vulgaris fruit extract on oxidative stress status in the kidney and liver of diabetic rats
  10. Fetal protective effect of Indonesian propolis from Apis mellifera against rifampicin-pyrazinamide induced impaired pregnancy in BALB/c mice
  11. Dietary supplementation with seeds of Sesamum indicum L. (pedaliaceae) mitigates the 7,12-dimethylbenz(a)anthracene-induced breast tumor burden in rats
  12. The effect of Artemisia annua L. aqueous and methanolic extracts on insulin signaling in liver of HFD/STZ diabetic mice
  13. A preclinical study to determine the anti-epileptic effect of biotin on maximal electroshock (MES) and pentylenetetrazole (PTZ) models in albino rats
  14. Caffeic acid attenuates memory dysfunction and restores the altered activity of cholinergic, monoaminergic and purinergic in brain of cadmium chloride exposure rats
  15. Research progress on rat model of drug-induced liver injury established by nonsteroidal anti-inflammatory drug (celecoxib) and royal jelly ameliorative effect
  16. Anti-inflammatory, anti-oxidant and anti-ulcer activities of aqueous lyophilizate of Markhamia lutea (Bignoniaceae)
  17. Effects of Laghoo Shankaprakshalana (yogic colon cleansing) on anthropometric measurements in obese individuals
  18. Short Communication
  19. A short review on deciphering Vyadhikshamatva: insights from HLA-B27-ankylosing spondylitis relation
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