Anti-inflammatory activity of Buchholzia coriacea Engl. (Capparaceae) leaf extract: evaluation of components of the inflammatory response involved
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Adaobi C. Ezike
,
Collins A. Onyeto
Abstract
Background: Earlier studies in our laboratory demonstrated the anti-inflammatory activity of Buchholzia coriacea Engl. (Capparaceae) leaf extract, a herbal remedy used to treat disorders of inflammation. This study was undertaken to evaluate its anti-inflammatory mechanism(s).
Methods: The effects of methanol leaf extract of B. coriacea (200 and 400 mg/kg) on vascular permeability and leukocyte migration were studied in rodents, while activity on complement system and membrane stabilization were evaluated in vitro.
Results: The extract (200 and 400 mg/kg) inhibited acetic acid-induced increase in vascular permeability in a non-dose-related manner and significantly (p<0.05) reduced the total and differential leukocyte counts, respectively, in a dose-related manner. It also significantly (p<0.05) inhibited complement-induced hemolysis of sheep red blood cells (40–72 %) and moderately inhibited heat- (6 %) and hypotonic solution-(24 %) induced hemolysis in vitro in a non-dose-related manner.
Conclusions: Results demonstrated that the anti-inflammatory activity of B. coriacea leaf extract is mediated through inhibition of increase in vascular permeability, leukocyte migration and complement system, and enhanced membrane stabilization.
Author contributions
All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding
None declared.
Employment or leadership
None declared.
Honorarium
None declared.
Competing interests
The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report or in the decision to submit the report for publication.
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Articles in the same Issue
- Frontmatter
- Reviews
- Ayurveda in changing scenario of diabetes management for developing safe and effective treatment choices for the future
- Trends in publications on complementary and alternative medicine in the medical literature
- Preclinical Studies
- Effect of Withania somnifera (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats
- The effect of Terminalia chebula extract vs. silver sulfadiazine on burn wounds in rats
- Protective effect of some selected fruit blends on testicular toxicity in alloxan-induced diabetic rats
- Therapeutic interventions using a combination of Telmisartan and omega 3-fatty acids in sodium arsenite-induced vascular endothelial dysfunction in rats: modulation through ATP-sensitive K+ channels and eNOS
- Anti-inflammatory activity of Buchholzia coriacea Engl. (Capparaceae) leaf extract: evaluation of components of the inflammatory response involved
- Clinical Studies
- Effect of daily drinking of Aloe vera gel extract on plasma total antioxidant capacity and oral pathogenic bacteria in healthy volunteer: a short-term study
- The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes
- Short Communication
- In-vitro anthelmintic activity of three Bangladeshi plants against Paramphistomum cervi and Haemonchus contortus
