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Therapeutic potential of resveratrol: novel biological and pharmacological perspectives

  • Milad Ashrafizadeh ORCID logo EMAIL logo
Published/Copyright: July 11, 2025

Abstract

The application of natural occurring compounds in the treatment of human diseases has been increased in the recent decades due to the biocompatibility and pleiotropic impacts of these agents along with significant health-promoting effects. Among them, resveratrol has been shown to be of importance, since it can exert various biological and pharmacological activities. Moreover, resveratrol generally demonstrates good biosafety and biocompatibility that can further improve its application in clinical studies. In terms of biological activities, the antioxidant and anti-inflammatory activities of resveratrol has been of importance and they are useful in the prevention of diabetes and neurological diseases. The antioxidant activity of resveratrol can result from its function in enhancing levels of antioxidant factors such as catalase and superoxide dismutase, and reduction in ROS levels. Moreover, resveratrol can reduce inflammation and downregulate related pathways such as NF-κB. Beyond this, resveratrol has been shown to be beneficial in the treatment of human diseases such as diabetes mellitus, cancer (suppressing tumorigenesis or acting as chemopreventive agent) and alleviation of neurological diseases, among others. Such protective impacts of resveratrol would be discussed in the current review with a focus on underlying molecular factors. In addition, nanoparticles have been significantly applied in the treatment of human disease through delivery of resveratrol and since pharmacokinetic profile of resveratrol is poor, the application of delivery systems can accelerate therapeutic index of this natural product. However, clinical application of resveratrol-loaded nanoparticles in the clinical level relies on the biocomaptibility and safety of these structures along with their efficacy.


Corresponding author: Milad Ashrafizadeh, Department of Radiation Oncology, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, 250000, China, E-mail:

Acknowledgments

The author is thankful to Biorender (Biorender.com).

  1. Research ethics: Not applicable. This is a review manuscript.

  2. Informed consent: Not applicable. This is a review article.

  3. Author contributions: Milad Ashrafizadeh, Conceptualization; Writing-review editing; Writing-original draft, Developing figures and tables.

  4. Use of Large Language Models, AI and Machine Learning Tools: Author of this paper has not used these tools for the preparation of paper.

  5. Conflict of interest: Author states no conflict of interest.

  6. Research funding: None declared.

  7. Data availability: Not applicable, as this manuscript is a review paper.

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Received: 2024-11-14
Accepted: 2025-06-28
Published Online: 2025-07-11

© 2025 Walter de Gruyter GmbH, Berlin/Boston

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