Evaluation of the serum level of CTRP-3 and CTRP-6 in patients with Hashimoto’s disease and correlation with thyroid hormones and lipid profile

Rafal Sameer Al-Abboody; Nadia Heydari; Mohsen Saravani; Shahin Nosaratzehi; Hamideh Akbari; Seyyed Mehdi Jafari

doi:10.1515/jbcpp-2024-0060

Article

Evaluation of the serum level of CTRP-3 and CTRP-6 in patients with Hashimoto’s disease and correlation with thyroid hormones and lipid profile

Rafal Sameer Al-Abboody , Nadia Heydari , Mohsen Saravani , Shahin Nosaratzehi , Hamideh Akbari and Seyyed Mehdi Jafari

Published/Copyright: January 21, 2025

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From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 36 Issue 1

Abstract

Objectives

Numerous studies show that the adipokines play a role in on the thyroid axis. The aim of this study was the evaluation of serum level of CTRP-3 and CTRP-6 as a member of the adipokines family in patients with Hashimoto’s.

Methods

The levels of CTRP-3 and CTRP-6 were evaluated with enzyme-linked immunosorbent assay in 70 subjects (35 newly diagnosed Hashimoto’s thyroiditis and 35 healthy subjects). Their relationship with the thyroid hormone and some biochemical factors was analyzed.

Results

The levels of CTRP3 and CTRP6 in patients with Hashimoto’s disease were higher than those in the control group (p<0.05). There was a significant positive correlation between CTRP3 and TSH levels (r=0.286 and p=0.017). There was a significant relationship between CTRP3 and Fasting Blood Sugar (r=0.249 and p=0.038). There was a significant inverse negative correlation between CTRP6 levels and T3 (r=−0.269 and p=0.024), and T4 (r=−0.272 and p=0.023). Moreover, there was a significant positive correlation between CTRP6 serum levels and TSH serum levels (r=0.397 and p=0.001). There was a significant positive correlation between CTRP6 levels and Cholesterol (r=0.351 and p=0.003), and LDL (r=−0.244 and p=0.042).

Conclusions

Finally, our results demonstrated that serum levels of CTRP3 and CTRP6 are higher in patients with Hashimoto’s compared to the control group and probably play a role in the pathogenesis of Hashimoto’s thyroiditis.

Keywords: autoimmune diseases; Hashimoto’s disease; CTRP3; CTRP6; thyroid hormone; lipid profiles

Corresponding author: Seyyed Mehdi Jafari, PhD, Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran and Department of Biochemistry and Biophysics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran, E-mail: s.meh.jafari@goums.ac.ir

Funding source: Golestan University of Medical Sciences

Award Identifier / Grant number: 112822

Acknowledgments

This study was obtained from the thesis of Ms. Rafal SamerAL-aboody, a master’s student in clinical biochemistry at Golestan University of Medical Sciences with grant number: 112822.

Research ethics: The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). This study was in agreement with the ethics committee of Golestan University of Medical Sciences that approved the study protocol (IR.GOUMS.REC.1401.151).
Informed consent: Informed consent was obtained from all individuals included in this study, or their legal guardians or wards.
Author contributions: Data collection and draft manuscript: Rafal Samer Al-Aboody. Data analyzing and editing of manuscript: Nadia Hydari Collection of clinical samples: Shahin Nosartzehi, Mohsen Saravani and Hamideh Akbari Study design and Supervision of the research: Seyyed Mehdi Jafari Final version of the manuscript edited and approved by all authors.
Conflict of interest: The authors declare no conflicts of interest.
Use of Large Language Models, AI and Machine Learning Tools: None declared.
Research funding: This study was supported by Golestan University of Medical Sciences with grant number of 112822.
Data availability: The raw data can be obtained on request from the corresponding author.

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Received: 2024-04-17

Accepted: 2024-12-20

Published Online: 2025-01-21

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Articles in the same Issue

https://doi.org/10.1515/jbcpp-2024-0060

Keywords for this article

autoimmune diseases; Hashimoto’s disease; CTRP3; CTRP6; thyroid hormone; lipid profiles