Stem cell therapy in sports medicine: current applications, challenges and future perspectives
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Stefano Palermi
Abstract
Stem cells have demonstrated significant potential for tissue repair and regeneration, making them a promising therapeutic avenue in sports medicine. This review aims to provide a comprehensive overview of the current state of research on the application of stem cells in sports medicine. We will discuss the types of stem cells used, their mechanisms of action, and the clinical outcomes of stem cell therapy in different sports-related injuries. Furthermore, we will delve into the challenges and ethical considerations associated with stem cell therapy, as well as future directions and potential applications of stem cells in sports medicine.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: Conceptualization, S.P. and F.S.; methodology, A.C. and F.V.; resources, R.G. and I.I.; data curation, A.M.; writing—original draft preparation, I.B., A.S., D.T., V.R.; writing—review and editing, M.V., M.R.DL., A.D. All authors have read and agreed to the published version of the manuscript. The author(s) have (has) accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: None.
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Research funding: None.
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Data availability: Not applicable.
References
1. Yang, SX, Cheng, S, Su, DL. Sports injury and stressor-related disorder in competitive athletes: a systematic review and a new framework. Burns Trauma 2022;10:tkac017. https://doi.org/10.1093/burnst/tkac017.10.1093/burnst/tkac017Search in Google Scholar PubMed PubMed Central
2. Demeco, A, de Sire, A, Marotta, N, Spanò, R, Lippi, L, Palumbo, A, et al.. Match analysis, physical training, risk of injury and rehabilitation in padel: overview of the literature. Int J Environ Res Publ Health 2022;19:4153. https://doi.org/10.3390/ijerph19074153.Search in Google Scholar PubMed PubMed Central
3. Lambert, C, Ritzmann, R, Akoto, R, Lambert, M, Pfeiffer, T, Wolfarth, B, et al.. Epidemiology of injuries in Olympic sports. Int J Sports Med 2022;43:473–81. https://doi.org/10.1055/a-1641-0068.Search in Google Scholar PubMed
4. Maffulli, N, Longo, UG, Gougoulias, N, Caine, D, Denaro, V. Sport injuries: a review of outcomes. Br Med Bull 2011;97:47–80. https://doi.org/10.1093/bmb/ldq026.Search in Google Scholar PubMed
5. Stewart, CE. Stem cells and regenerative medicine in sport science. Emerg Top Life Sci 2021;5:563–73. https://doi.org/10.1042/ETLS20210014.10.1042/ETLS20210014Search in Google Scholar PubMed PubMed Central
6. Malanga, G, Nakamura, R. The role of regenerative medicine in the treatment of sports injuries. Phys Med Rehabil Clin 2014;25:881–95. https://doi.org/10.1016/j.pmr.2014.06.007.10.1016/j.pmr.2014.06.007Search in Google Scholar PubMed
7. Nawab, K, Bhere, D, Bommarito, A, Mufti, M, Naeem, A. Stem cell therapies: a way to promising cures. Cureus 2019;11:e5712. https://doi.org/10.7759/cureus.5712.10.7759/cureus.5712Search in Google Scholar PubMed PubMed Central
8. Hoang, DM, Pham, PT, Bach, TQ, Ngo, ATL, Nguyen, QT, Phan, TTK, et al.. Stem cell-based therapy for human diseases. Signal Transduct Targeted Ther 2022;7:272. https://doi.org/10.1038/s41392-022-01134-4.10.1038/s41392-022-01134-4Search in Google Scholar PubMed PubMed Central
9. Parizadeh, SM, Jafarzadeh-Esfehani, R, Ghandehari, M, Parizadeh, MR, Ferns, GA, Avan, A, et al.. Stem cell therapy: a novel approach for myocardial infarction. J Cell Physiol 2019;234:16904–12. https://doi.org/10.1002/jcp.28381.10.1002/jcp.28381Search in Google Scholar PubMed
10. Liu, J, Sluijter, JP, Goumans, MJ, Smits, AM, van der Spoel, T, Nathoe, H, et al.. Cell therapy for myocardial regeneration. Curr Mol Med 2009;9:287–98. https://doi.org/10.2174/156652409787847218.10.2174/156652409787847218Search in Google Scholar PubMed
11. Vecchiato, M, Zanardo, E, Battista, F, Quinto, G, Bergia, C, Palermi, S, et al.. The effect of exercise training on irisin secretion in patients with type 2 diabetes: a systematic review. J Clin Med 2023;12:62. https://doi.org/10.3390/jcm12010062.Search in Google Scholar PubMed PubMed Central
12. Aghazadeh, Y, Nostro, MC. Cell therapy for type 1 diabetes: current and future strategies. Curr Diabetes Rep 2017;17:37. https://doi.org/10.1007/s11892-017-0863-6.10.1007/s11892-017-0863-6Search in Google Scholar PubMed
13. Zeng, CW. Multipotent mesenchymal stem cell-based therapies for spinal cord injury: current progress and future prospects. Biology 2023;12:653. https://doi.org/10.3390/biology12050653.Search in Google Scholar PubMed PubMed Central
14. Ramalho, BDS, de Almeida, FM, Martinez, AMB. Cell therapy and delivery strategies for spinal cord injury. Histol Histopathol 2021;36:907–20. https://doi.org/10.14670/HH-18-350.Search in Google Scholar
15. Zakrzewski, W, Dobrzyński, M, Szymonowicz, M, Rybak, Z. Stem cells: past, present, and future. Stem Cell Res Ther 2019;10:68. https://doi.org/10.1186/s13287-019-1165-5.10.1186/s13287-019-1165-5Search in Google Scholar PubMed PubMed Central
16. Kolios, G, Moodley, Y. Introduction to stem cells and regenerative medicine. Respiration 2013;85:3–10. https://doi.org/10.1159/000345615.10.1159/000345615Search in Google Scholar PubMed
17. Zumwalt, M, Reddy, AP. Stem cells for treatment of Musculoskeletal conditions – Orthopaedic/sports medicine applications. Biochim Biophys Acta Mol Basis Dis 2020;1866:165624. https://doi.org/10.1016/j.bbadis.2019.165624.Search in Google Scholar PubMed
18. Mirghaderi, SP, Valizadeh, Z, Shadman, K, Lafosse, T, Oryadi-Zanjani, L, Yekaninejad, MS, et al.. Cell therapy efficacy and safety in treating tendon disorders: a systemic review of clinical studies. J Exp Orthop 2022;9:85. https://doi.org/10.1186/s40634-022-00520-9.10.1186/s40634-022-00520-9Search in Google Scholar PubMed PubMed Central
19. Randelli, P, Randelli, F, Ragone, V, Menon, A, D’Ambrosi, R, Cucchi, D, et al.. Regenerative medicine in rotator cuff injuries. BioMed Res Int 2014;2014:129515. https://doi.org/10.1155/2014/129515.Search in Google Scholar
20. Choong, C, Rao, MS. Human embryonic stem cells. Neurosurg Clin 2007;18:1–14. https://doi.org/10.1016/j.nec.2006.10.004.10.1016/j.nec.2006.10.004Search in Google Scholar PubMed
21. Bobbert, M. Ethical questions concerning research on human embryos, embryonic stem cells and chimeras. Biotechnol J 2006;1:1352–69. https://doi.org/10.1002/biot.200600179.10.1002/biot.200600179Search in Google Scholar PubMed
22. Ye, L, Swingen, C, Zhang, J. Induced pluripotent stem cells and their potential for basic and clinical sciences. Curr Cardiol Rev 2013;9:63–72. https://doi.org/10.2174/157340313805076278.10.2174/1573403X11309010008Search in Google Scholar
23. Aboul-Soud, MAM, Alzahrani, AJ, Mahmoud, A. Induced pluripotent stem cells (iPSCs)-Roles in regenerative therapies, disease modelling and Drug screening. Cells 2021;10:2319. https://doi.org/10.3390/cells10092319.10.3390/cells10092319Search in Google Scholar PubMed PubMed Central
24. Berebichez-Fridman, R, Montero-Olvera, PR. Sources and clinical applications of mesenchymal stem cells: state-of-the-art review. Sultan Qaboos Univ Med J 2018;18:e264–77. https://doi.org/10.18295/squmj.2018.18.03.002.10.18295/squmj.2018.18.03.002Search in Google Scholar PubMed PubMed Central
25. Zhao, S, Wehner, R, Bornhäuser, M, Wassmuth, R, Bachmann, M, Schmitz, M. Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders. Stem Cell Dev 2010;19:607–14. https://doi.org/10.1089/scd.2009.0345.10.1089/scd.2009.0345Search in Google Scholar PubMed
26. Lee, JY, Hong, SH. Hematopoietic stem cells and their roles in tissue regeneration. Int J Stem Cells 2020;13:1–12. https://doi.org/10.15283/ijsc19127.10.15283/ijsc19127Search in Google Scholar PubMed PubMed Central
27. Eaves, CJ. Hematopoietic stem cells: concepts, definitions, and the new reality. Blood 2015;125:2605–13. https://doi.org/10.1182/blood-2014-12-570200.10.1182/blood-2014-12-570200Search in Google Scholar PubMed PubMed Central
28. Mimeault, M, Batra, SK. Recent progress on tissue-resident adult stem cell biology and their therapeutic implications. Stem Cell Rev 2008;4:27–49. https://doi.org/10.1007/s12015-008-9008-2.10.1007/s12015-008-9008-2Search in Google Scholar PubMed PubMed Central
29. Di Meglio, F, Sacco, AM, Belviso, I, Romano, V, Sirico, F, Loiacono, C, et al.. Influence of supplements and drugs used for the treatment of musculoskeletal disorders on adult human tendon-derived stem cells. Muscles Ligaments Tendons J 2020;3:376–84. https://doi.org/10.32098/mltj.03.2020.04.10.32098/mltj.03.2020.04Search in Google Scholar
30. Johnson, TA, Singla, DK. Therapeutic application of adult stem cells in the heart. Methods Mol Biol 2017;1553:249–64. https://doi.org/10.1007/978-1-4939-6756-8_20.10.1007/978-1-4939-6756-8_20Search in Google Scholar PubMed
31. Gurusamy, N, Alsayari, A, Rajasingh, S, Rajasingh, J. Adult stem cells for regenerative therapy. Prog Mol Biol Transl Sci 2018;160:1–22. https://doi.org/10.1016/bs.pmbts.2018.07.009.10.1016/bs.pmbts.2018.07.009Search in Google Scholar PubMed
32. Chen, Z, Chen, P, Zheng, M, Gao, J, Liu, D, Wang, A, et al.. Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside. Stem Cell Res Ther 2022;13:444. https://doi.org/10.1186/s13287-022-03113-6.10.1186/s13287-022-03113-6Search in Google Scholar PubMed PubMed Central
33. Dominici, M, Le Blanc, K, Mueller, I, Slaper-Cortenbach, I, Marini, F, Krause, D, et al.. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315–17. https://doi.org/10.1080/14653240600855905.Search in Google Scholar PubMed
34. Diederichs, S, Shine, KM, Tuan, RS. The promise and challenges of stem cell-based therapies for skeletal diseases: stem cell applications in skeletal medicine: potential, cell sources and characteristics, and challenges of clinical translation. Bioessays 2013;35:220–30. https://doi.org/10.1002/bies.201200068.Search in Google Scholar
35. Duran, JM, Taghavi, S, George, JC. The need for standardized protocols for future clinical trials of cell therapy. Transl Res 2012;160:399–410. https://doi.org/10.1016/j.trsl.2012.07.004.10.1016/j.trsl.2012.07.004Search in Google Scholar PubMed
36. Matsumoto, T, Sato, Y, Kobayashi, T, Suzuki, K, Kimura, A, Soma, T, et al.. Adipose-derived stem cell sheets improve early biomechanical graft strength in rabbits after anterior cruciate ligament reconstruction. Am J Sports Med 2021;49:3508–18. https://doi.org/10.1177/03635465211041582.10.1177/03635465211041582Search in Google Scholar PubMed
37. Ellera Gomes, JL, da Silva, RC, Silla, LM, Abreu, MR, Pellanda, R. Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells. Knee Surg Sports Traumatol Arthrosc 2012;20:373–7. https://doi.org/10.1007/s00167-011-1607-9.Search in Google Scholar PubMed PubMed Central
38. Lamo-Espinosa, JM, Mora, G, Blanco, JF, Granero-Moltó, F, Núñez-Córdoba, JM, López-Elío, S, et al.. Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II). J Transl Med 2018;16:213. https://doi.org/10.1186/s12967-018-1591-7.10.1186/s12967-018-1591-7Search in Google Scholar PubMed PubMed Central
39. Mautner, K, Blazuk, J. Where do injectable stem cell treatments apply in treatment of muscle, tendon, and ligament injuries? Phys Med Rehabil 2015;7:S33–40. https://doi.org/10.1016/j.pmrj.2014.12.012.Search in Google Scholar PubMed
40. Hernigou, P, Delambre, J, Quiennec, S, Poignard, A. Human bone marrow mesenchymal stem cell injection in subchondral lesions of knee osteoarthritis: a prospective randomized study versus contralateral arthroplasty at a mean fifteen year follow-up. Int Orthop 2021;45:365–73. https://doi.org/10.1007/s00264-020-04571-4.Search in Google Scholar PubMed
41. Dezawa, M, Kanno, H, Hoshino, M, Cho, H, Matsumoto, N, Itokazu, Y, et al.. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest 2004;113:1701–10. https://doi.org/10.1172/JCI20935.Search in Google Scholar PubMed PubMed Central
42. Herberts, CA, Kwa, MS, Hermsen, HP. Risk factors in the development of stem cell therapy. J Transl Med 2011;9:29. https://doi.org/10.1186/1479-5876-9-29.Search in Google Scholar
43. Trebinjac, S, Gharairi, M. Mesenchymal stem cells for treatment of tendon and ligament injuries-clinical evidence. Med Arch 2020;74:387–90. https://doi.org/10.5455/medarh.2020.74.387-390.10.5455/medarh.2020.74.387-390Search in Google Scholar PubMed PubMed Central
44. Randelli, P, Randelli, F, Ragone, V, Menon, A, D’Ambrosi, R, Cucchi, D, et al.. Regenerative medicine in rotator cuff injuries. BioMed Res Int 2014;2014:129515. https://doi.org/10.1155/2014/129515.10.1155/2014/129515Search in Google Scholar PubMed PubMed Central
45. Usuelli, FG, Grassi, M, Maccario, C, Vigano’, M, Lanfranchi, L, Alfieri Montrasio, U, et al.. Intratendinous adipose-derived stromal vascular fraction (SVF) injection provides a safe, efficacious treatment for Achilles tendinopathy: results of a randomized controlled clinical trial at a 6-month follow-up. Knee Surg Sports Traumatol Arthrosc 2018;26:2000–10. https://doi.org/10.1007/s00167-017-4479-9.Search in Google Scholar PubMed
46. van den Boom, NAC, Winters, M, Haisma, HJ, Moen, MH. Efficacy of stem cell therapy for tendon disorders: a systematic review. Orthop J Sports Med 2020;8:2325967120915857. https://doi.org/10.1177/2325967120915857.10.1177/2325967120915857Search in Google Scholar PubMed PubMed Central
47. Uth, K, Trifonov, D. Stem cell application for osteoarthritis in the knee joint: a minireview. World J Stem Cell 2014;6:629–36. https://doi.org/10.4252/wjsc.v6.i5.629.Search in Google Scholar PubMed PubMed Central
48. Rahim, S, Rahim, F, Shirbandi, K, Haghighi, BB, Arjmand, B. Sports injuries: diagnosis, prevention, stem cell therapy, and medical sport strategy. Adv Exp Med Biol 2019;1084:129–44. https://doi.org/10.1007/5584_2018_298.10.1007/5584_2018_298Search in Google Scholar PubMed
49. Davatchi, F, Abdollahi, BS, Mohyeddin, M, Shahram, F, Nikbin, B. Mesenchymal stem cell therapy for knee osteoarthritis: preliminary report of four patients. Int J Rheum Dis 2011;14:211–15. https://doi.org/10.1111/j.1756-185x.2011.01599.x.Search in Google Scholar
50. Im, GI. Clinical use of stem cells in orthopaedics. Eur Cell Mater 2017;33:183–96. https://doi.org/10.22203/eCM.v033a14.10.22203/eCM.v033a14Search in Google Scholar PubMed
51. Lappin, T, Cheng, T. An urgent need for standardization of stem cells and stem cell-derived products toward clinical applications. Stem Cells Transl Med 2021;10:S1–S3. https://doi.org/10.1002/sctm.21-0269.10.1002/sctm.21-0269Search in Google Scholar PubMed PubMed Central
52. Herberts, CA, Kwa, MS, Hermsen, HP. Risk factors in the development of stem cell therapy. J Transl Med 2011;9:29. https://doi.org/10.1186/1479-5876-9-29.10.1186/1479-5876-9-29Search in Google Scholar PubMed PubMed Central
53. Lezmi, E, Benvenisty, N. The tumorigenic potential of human pluripotent stem cells. Stem Cells Transl Med 2022;11:791–6. https://doi.org/10.1093/stcltm/szac039.10.1093/stcltm/szac039Search in Google Scholar PubMed PubMed Central
54. Neri, S. Genetic stability of mesenchymal stromal cells for regenerative medicine applications: a fundamental biosafety aspect. Int J Mol Sci 2019;20:2406. https://doi.org/10.3390/ijms20102406.Search in Google Scholar PubMed PubMed Central
55. Sugarman, J, Barker, RA, Charo, RA. A professional standard for informed consent for stem cell therapies. JAMA 2019;322:1651–2. https://doi.org/10.1001/jama.2019.11290.10.1001/jama.2019.11290Search in Google Scholar PubMed
56. Welin, S. Ethical issues in human embryonic stem cell research. Acta Obstet Gynecol Scand 2002;81:377–82. https://doi.org/10.1034/j.1600-0412.2002.810501.x.10.1034/j.1600-0412.2002.810501.xSearch in Google Scholar PubMed
57. Liu, SP, Fu, RH, Huang, YC, Chen, SY, Chien, YJ, Hsu, CY, et al.. Induced pluripotent stem (iPS) cell research overview. Cell Transplant 2011;20:15–19. https://doi.org/10.3727/096368910X532828.10.3727/096368910X532828Search in Google Scholar PubMed
58. Turner, L, Knoepfler, P. Selling stem cells in the USA: assessing the direct-to-consumer industry. Cell Stem Cell 2016;19:154–7. https://doi.org/10.1016/j.stem.2016.06.007.10.1016/j.stem.2016.06.007Search in Google Scholar PubMed
59. Diederichs, S, Shine, KM, Tuan, RS. The promise and challenges of stem cell-based therapies for skeletal diseases: stem cell applications in skeletal medicine: potential, cell sources and characteristics, and challenges of clinical translation. Bioessays 2013;35:220–30. https://doi.org/10.1002/bies.201200068.10.1002/bies.201200068Search in Google Scholar PubMed PubMed Central
60. Martin, RM, Fowler, JL, Cromer, MK, Lesch, BJ, Ponce, E, Uchida, N, et al.. Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards. Nat Commun 2020;11:2713. https://doi.org/10.1038/s41467-020-16455-7.10.1038/s41467-020-16455-7Search in Google Scholar PubMed PubMed Central
61. Lo, B, Parham, L. Ethical issues in stem cell research. Endocr Rev 2009;30:204–13. https://doi.org/10.1210/er.2008-0031.10.1210/er.2008-0031Search in Google Scholar PubMed PubMed Central
62. Ajibade, DA, Vance, DD, Hare, JM, Kaplan, LD, Lesniak, BP. Emerging applications of stem cell and regenerative medicine to sports injuries. Orthop J Sports Med 2014;2:2325967113519935. https://doi.org/10.1177/2325967113519935.10.1177/2325967113519935Search in Google Scholar PubMed PubMed Central
63. Beetler, DJ, Di Florio, DN, Law, EW, Groen, CM, Windebank, AJ, Peterson, QP, et al.. The evolving regulatory landscape in regenerative medicine. Mol Aspect Med 2023;91:101138. https://doi.org/10.1016/j.mam.2022.101138.10.1016/j.mam.2022.101138Search in Google Scholar PubMed PubMed Central
64. Board on health sciences policy; board on life sciences; division on earth and life studies; institute of medicine; national academy of sciences. Stem Cell Therapies: Opportunities for Ensuring the Quality and Safety of Clinical Offerings: Summary of a Joint Workshop. Washington (DC): National Academies Press (US); 2014, vol 4, Comparative Regulatory and Legal Frameworks. Available from: https://www.ncbi.nlm.nih.gov/books/NBK223198/.Search in Google Scholar
65. Rossoni, A, Vecchiato, M, Brugin, E, Tranchita, E, Adami, PE, Bartesaghi, M, et al.. The eSports medicine: pre-participation screening and injuries management—an update. Sports 2023;11:34. https://doi.org/10.3390/sports11020034.Search in Google Scholar PubMed PubMed Central
66. Palermi, S, Massa, B, Vecchiato, M, Mazza, F, De Blasiis, P, Romano, AM, et al.. Indirect structural muscle injuries of lower limb: rehabilitation and therapeutic exercise. J Funct Morphol Kinesiol 2021;6:75. https://doi.org/10.3390/jfmk6030075.Search in Google Scholar PubMed PubMed Central
67. Belviso, I, Palermi, S, Sacco, AM, Romano, V, Corrado, B, Zappia, M, et al.. Brachial plexus injuries in sport medicine: clinical evaluation, diagnostic approaches, treatment options, and rehabilitative interventions. J Funct Morphol Kinesiol 2020;5:22. https://doi.org/10.3390/jfmk5020022.Search in Google Scholar PubMed PubMed Central
© 2023 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Breaking the mold: revolutionary new obesity drugs set to transform treatment landscape?
- Reviews
- The relationship between the history of PDE5-inhibitors assumption and melanoma: a systematic review
- Stem cell therapy in sports medicine: current applications, challenges and future perspectives
- Original Articles
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- Isotonic saline causes greater volume overload than electrolyte-free irrigating fluids
- Anti-atherosclerotic activity of aqueous extract of Ipomoea batatas (L.) leaves in high-fat diet-induced atherosclerosis model rats
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- Effect of habitual breakfast skipping on information processing capacity, cortical response, and cognitive flexibility among medical collegiate – a cross-sectional study
- Association of neck circumference and waist-hip ratio with total leukocyte count in healthy Indian adolescents
- 3-Day food record: efficacy in patients with type 2 diabetes mellitus
- Development and user acceptability testing of healthy heart mobile application – a tool for cardiovascular risk modification among patients with type 2 diabetes mellitus
- Effectiveness of electrical vestibular nerve stimulation on the range of motion in patients with Parkinson’s disease
- Intra-operative drug level monitoring of pre-operative antibiotic for surgical prophylaxis in the patients of elective spinal surgery
- Case Report
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Articles in the same Issue
- Frontmatter
- Editorial
- Breaking the mold: revolutionary new obesity drugs set to transform treatment landscape?
- Reviews
- The relationship between the history of PDE5-inhibitors assumption and melanoma: a systematic review
- Stem cell therapy in sports medicine: current applications, challenges and future perspectives
- Original Articles
- Modulatory action of Moringa oleifera Lam. on L-arginine induced acute pancreatitis
- Isotonic saline causes greater volume overload than electrolyte-free irrigating fluids
- Anti-atherosclerotic activity of aqueous extract of Ipomoea batatas (L.) leaves in high-fat diet-induced atherosclerosis model rats
- Efficacy of Habb-e-Asab in diabetic peripheral neuropathy: a randomized placebo control study
- Indoleamine 2,3-dioxygenase controls purinergic receptor-mediated ischemia-reperfusion injury in renal tubular epithelial cells
- Effect of habitual breakfast skipping on information processing capacity, cortical response, and cognitive flexibility among medical collegiate – a cross-sectional study
- Association of neck circumference and waist-hip ratio with total leukocyte count in healthy Indian adolescents
- 3-Day food record: efficacy in patients with type 2 diabetes mellitus
- Development and user acceptability testing of healthy heart mobile application – a tool for cardiovascular risk modification among patients with type 2 diabetes mellitus
- Effectiveness of electrical vestibular nerve stimulation on the range of motion in patients with Parkinson’s disease
- Intra-operative drug level monitoring of pre-operative antibiotic for surgical prophylaxis in the patients of elective spinal surgery
- Case Report
- The black swan: a case of central nervous system graft-versus-host disease