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Antioxidant therapy for hepatic diseases: a double-edged sword

  • Sayandeep K. Das , Savitri M. Nerune and Kusal K. Das EMAIL logo
Published/Copyright: January 19, 2024
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 35 Issue 1-2

Abstract

Liver diseases are complex conditions, significantly influenced by oxidative stress. This comprehensive review assesses the therapeutic role of antioxidants like l-ascorbic acid and α tocopherol, beta-carotene, various minerals, and plant-based ingredients in mitigating oxidative stress-induced liver diseases. The manuscript delves into the critical influence of genetic and epigenetic factors on disease susceptibility, progression, and response to antioxidant therapy. While animal studies suggest antioxidant efficacy in liver disease treatment, human trials remain inconclusive, and caution is advised due to its possible potential pro-oxidant effects. Moreover, the interactions of antioxidants with other drugs necessitate careful consideration in the management of polypharmacy in liver disease patients. The review underscores the need for further research to establish the clinical benefits of antioxidants with understanding of possible antioxidant toxicities to elucidate the intricate interplay of genetic, epigenetic, and environmental factors in liver diseases. The aim is to foster a better understanding of the knowledge on hepatic disease management with judicial antioxidant therapies.

Keywords: oxidative stress; free radicals; antioxidants; hepatic diseases; limitations
Corresponding author: Prof. Kusal K. Das, Distinguished Chair Professor, Laboratory of Vascular Physiology and Medicine, Department of Physiology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapur 586103, Karnataka, India, Phone: 91 8352 262770 (Extension 2262 & 2267), E-mail:

Acknowledgments

Authors are thankful to Professor Swastika Das. Professor and Head, Department of Chemistry, BLDEA’s College of Engineering and Technology, Vijayapur, India for providing valuable inputs and guidance.

  1. Research ethics: Not applicable. The local Institutional Review Board deemed the study exempt from review.

  2. Informed consent: No applicable.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: Authors state no conflict of interest.

  5. Research funding: None declared.

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Received: 2023-06-20
Accepted: 2024-01-02
Published Online: 2024-01-19

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2023-0156
Keywords for this article
oxidative stress; free radicals; antioxidants; hepatic diseases; limitations

Articles in the same Issue

  1. Frontmatter
  2. Editorials
  3. Can small molecule GLP-1 agonists be the next first-line drugs in type-2 diabetes mellitus?
  4. From Dr. Google to CE-marked medical devices: need for ethical and legal safeguards
  5. Minireview
  6. Antioxidant therapy for hepatic diseases: a double-edged sword
  7. Reviews
  8. Effect of cannabinoids in mild-to-moderate cases of Crohn’s disease as compared to placebo: a systematic review and meta-analysis of randomised controlled trials
  9. Evidences and therapeutic advantages of donanemab in the treatment of early Alzheimer’s disease
  10. Alzheimer’s disease and clinical trials
  11. Original Articles
  12. Pioglitazone attenuate level of myeloperoxidases and nitic oxide in psoriatic lesion: a proof-of-concept study in a imiquimod induced psoriasis model in rat
  13. Protecting cardiomyocytes from hypoxia-reoxygenation injury, empaglifozin and liraglutide alone or in combination?
  14. Gasotransmitters do not prevent changes in transepithelial ion transport induced by hypoxia followed by reoxygenation
  15. High-intensity combination exercise has the highest effect on increasing serum irisin and interleukin 6 levels in women with obesity
  16. Impact of heat stress on thermal balance, hydration and cortical response among outdoor workers in hot environment – an exploratory report from North East India
  17. Maternal separation influences hepatic drug-metabolizing CYP450 gene expression without pathological changes in adult mice
  18. Case Report
  19. Preoperative CT diagnosis of perforated Meckel’s diverticulitis in a young patient: a case report
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