Home Medicine High-intensity combination exercise has the highest effect on increasing serum irisin and interleukin 6 levels in women with obesity
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High-intensity combination exercise has the highest effect on increasing serum irisin and interleukin 6 levels in women with obesity

  • Uswatun Hasanah ORCID logo , Purwo Sri Rejeki ORCID logo EMAIL logo , Citrawati Dyah Kencono Wungu ORCID logo , Adi Pranoto ORCID logo , Nabilah Izzatunnisa ORCID logo , Ilham Rahmanto ORCID logo and Shariff Halim ORCID logo
Published/Copyright: March 15, 2024
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 35 Issue 1-2

Abstract

Objectives

Lifestyle, overnutrition, socioeconomic status, environmental conditions, and genetics are factors that cause obesity. Lifestyle modification with a nonpharmacological approach based on physical exercise is the starting point in overcoming obesity. However, physical exercise with the appropriate and effective intensity for obese subjects is still debated. Therefore, this study aims to prove the effect of intensity differences with aerobic-resistance combination exercise on increasing irisin and IL-6 levels in obese women.

Methods

A total of 32 obese women were selected as subjects and administered the interventions of low-intensity combination exercise (Q2), moderate-intensity combination exercise (Q3), and high-intensity combination exercise (Q4). ELISA was used to measure irisin and IL-6 levels in all samples. Statistical analysis used one-way ANOVA and Turkey’s-Honest Significant Difference (HSD) post hoc test.

Results

The mean Δ IL-6 levels in the control groups (Q1), Q2, Q3, and Q4 were 0.27 ± 2.54, 2.07 ± 2.55, 5.99 ± 6.25, and 7.98 ± 2.82 pg/mL with (p=0.015). The mean Δ irisin levels were 0.06 ± 0.81 ng/mL in Q1, 0.59 ± 0.67 ng/mL in Q2, 1.99 ± 1.65 ng/mL in Q3, 4.63 ± 3.57 ng/mL in Q4 with (p=0.001).

Conclusions

This study proved that all three types of combined exercise intensity increased myokine levels, such as irisin and IL-6. However, high-intensity combination exercise provided the most optimal improvement in myokine levels in obese women. Future studies are needed to design long-term exercise programs specifically for obese adolescent women using the findings from this study.

Keywords: exercise; metabolic syndrome; myokine; obesity; sedentary lifestyle
Corresponding author: Purwo Sri Rejeki, Department of Medical Physiology and Biochemistry, Kampus A, UNAIR. Jl. Mayjen Prof. Dr. Moestopo No. 47, 60132, Surabaya, Jawa Timur, Indonesia, E-mail:

Funding source: Directorate of Technology Research and Community Service of the Ministry of Education, Culture, Research, and Technology

Award Identifier / Grant number: 834/UN3.15/PT/2022

Acknowledgments

The authors would like to acknowledge the Faculty of Medicine, Universitas Airlangga, for supporting this project. We would also like to express our gratitude to all the subjects who participated in this research.

  1. Research ethics: All procedures applied in this study have complied with the World Medical Association Declaration of Helsinki and were approved by the Health Research Ethics Commission, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia, with No. 12/EC/KEPK/FKUA/2023.

  2. Informed consent: Informed consent was obtained from all individuals included in this study, or their legal guardians or wards.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: Authors state no conflict of interest.

  5. Research funding: All the expenses of this research were supported by the Directorate of Technology Research and Community Service of the Ministry of Education, Culture, Research, and Technology with grant number: 834/UN3.15/PT/2022.

  6. Data availability: The raw data can be obtained on request from the corresponding author.

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Received: 2023-06-09
Accepted: 2024-02-28
Published Online: 2024-03-15

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2023-0150
Keywords for this article
exercise; metabolic syndrome; myokine; obesity; sedentary lifestyle

Articles in the same Issue

  1. Frontmatter
  2. Editorials
  3. Can small molecule GLP-1 agonists be the next first-line drugs in type-2 diabetes mellitus?
  4. From Dr. Google to CE-marked medical devices: need for ethical and legal safeguards
  5. Minireview
  6. Antioxidant therapy for hepatic diseases: a double-edged sword
  7. Reviews
  8. Effect of cannabinoids in mild-to-moderate cases of Crohn’s disease as compared to placebo: a systematic review and meta-analysis of randomised controlled trials
  9. Evidences and therapeutic advantages of donanemab in the treatment of early Alzheimer’s disease
  10. Alzheimer’s disease and clinical trials
  11. Original Articles
  12. Pioglitazone attenuate level of myeloperoxidases and nitic oxide in psoriatic lesion: a proof-of-concept study in a imiquimod induced psoriasis model in rat
  13. Protecting cardiomyocytes from hypoxia-reoxygenation injury, empaglifozin and liraglutide alone or in combination?
  14. Gasotransmitters do not prevent changes in transepithelial ion transport induced by hypoxia followed by reoxygenation
  15. High-intensity combination exercise has the highest effect on increasing serum irisin and interleukin 6 levels in women with obesity
  16. Impact of heat stress on thermal balance, hydration and cortical response among outdoor workers in hot environment – an exploratory report from North East India
  17. Maternal separation influences hepatic drug-metabolizing CYP450 gene expression without pathological changes in adult mice
  18. Case Report
  19. Preoperative CT diagnosis of perforated Meckel’s diverticulitis in a young patient: a case report
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