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Dynamic of irisin secretion change after moderate-intensity chronic physical exercise on obese female

  • Desiana Merawati EMAIL logo , Sugiharto , Hendra Susanto , Ahmad Taufiq , Adi Pranoto , Dessy Amelia and Purwo Sri Rejeki
Published/Copyright: May 22, 2023
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 34 Issue 4

Abstract

Objectives

Exercise is one of the beneficial mediators for the regulation and prevention of obesity through the role of irisin, so it potentially enhances metabolism health. This study aims to investigate the dynamic of irisin secrecy change after chronic exercise in obese females.

Methods

Thirty-one female adolescents aged 20–22 years enrolled in the study and were given interventions aerobic, resistance, and a combination of aerobic and resistance training. The exercises were performed at moderate-intensity, for 35–40 min per session, and three times a week for four weeks. The measurement of irisin level, IGF-1 level, and bio-anthropometry was carried out before and after the four weeks of exercise. The bio-anthropometry measurement was carried out using seca mBCA 514, while the measurement of insulin-like growth factor 1 (IGF-1) and irisin was completed using an enzyme-linked immunosorbent assay (ELISA). The obtained data were analyzed using a one-way ANOVA test with 5 % significance.

Results

Our results indicated higher dynamic of irisin and IGF-1 increases in the group with a combination of aerobic and resistance training exercises than the other two groups with a different exercise. Further, we also observed different dynamics of irisin and IGF-1 level increase (p<0.05). Besides, the irisin was also correlated with the IGF-1 and bio-anthropometric parameters (p<0.05).

Conclusions

The combination of aerobic and resistance training exercises is considered as the alternative for enhancing the dynamic of irisin and IGF-1 increase. Thus, it can be used to prevent and regulate obesity.

Keywords: aerobic training; metabolism health; obesity; resistance training
Corresponding author: Desiana Merawati, Department of Sport Science, Faculty of Sport Science, Universitas Negeri Malang, Malang, Indonesia, Phone: +62 81 334 274 994, E-mail:

Funding source: Universitas Negeri Malang

Award Identifier / Grant number: 19.5.577/UN32.20.1/LT/2022

Funding source: Universitas Negeri Malang

Award Identifier / Grant number: Unassigned

Acknowledgments

We would like to express special gratitude to the Management of Atlas Sports Club Malang and Faculty of Sports Science, Universitas Negeri Malang for providing good facilities for making the process of research a success. We also thank all subjects who have participated in this study.

  1. Research funding: This study was supported by the 2022 PNBP research grant, State University of Malang, Indonesia, with Grant Number: 19.5.577/UN32.20.1/LT/2022.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Written informed consent was obtained before the students were enrolled as the subjects.

  5. Ethical approval: This study has been approved by the Health Research Ethics Committee of the Faculty of Medicine, Universitas Airlangga, Surabaya, under registered number 16/EC/KEPK/FKUA/2022.

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Received: 2023-02-09
Accepted: 2023-05-08
Published Online: 2023-05-22

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2023-0041
Keywords for this article
aerobic training; metabolism health; obesity; resistance training

Articles in the same Issue

  1. Frontmatter
  2. Minireview
  3. Impact of mental toughness on athlete’s performance and interventions to improve
  4. Reviews
  5. A review of the mechanisms of anti-cancer activities of some medicinal plants–biochemical perspectives
  6. Antimicrobials in COVID-19: strategies for treating a COVID-19 pandemic
  7. Anxiolytic effects of vestibular stimulation: an update
  8. Original Articles
  9. Intermittent exposure to green and white light-at-night activates hepatic glycogenolytic and gluconeogenetic activities in male Wistar rats
  10. Study of pre-operative neutrophil–lymphocyte ratio in urothelial carcinoma
  11. The effects of Berberis vulgaris L. root extract on the opiate withdrawal syndrome and psychological factors: a randomized double-blind clinical trial
  12. Evidence of alterations in the learning and memory in offspring of stress-induced male rats
  13. The impact of vestibular symptoms and electronystagmography results on recovery from sudden sensorineural hearing loss
  14. Complementary mechanisms of modulation of spontaneous phasic contractions by the gaseous signalling molecules NO, H2S, HNO and the polysulfide Na2S3 in the rat colon
  15. Pharmacist-directed Sputnik V (GAM-COVID-VAC) surveillance program: a prospective observational study in Southern India
  16. Correlation among Poincare plot and traditional heart rate variability indices in adults with different risk levels of metabolic syndrome: a cross-sectional approach from Southern India
  17. Does etodolac affect TRPA1 functionality in vivo in human?
  18. Dynamic of irisin secretion change after moderate-intensity chronic physical exercise on obese female
  19. Letter to the Editor
  20. The prospective record-breaking obesity drug tirzepatide raises concerns about affordability
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