Zinc oxide nanoparticles with green tea extract complex in the pancreas of rats against monosodium glutamate toxicity
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Reham Z. Hamza
Abstract
Objectives
Nanotechnology is an exciting field for investigators. Green zinc oxide nanoparticles (ZnO NPs) with Camellia sinensis extract complex are proved to be used in the treatment of the toxicity of monosodium glutamate (MSG) in the liver, kidney, and testis of rats. Therefore, the synthesized complex of green nanoparticles using green tea extract (GTE) was tested against the toxicity of MSG on the pancreas.
Methods
The glucose and insulin levels were estimated as well as some biochemical parameters for evaluating the antioxidant status of the pancreas tissue. The histopathological change of the pancreas also has been determined.
Results
It indicates the biomedical capability of ZnO NPs/GTE to act as potent antidiabetic through decreasing blood glucose and increasing serum insulin also, inhibition of lipid peroxidation and enhancement of the antioxidant parameters.
Conclusions
The ZnO NPs/GTE enhanced the pancreatic cell and Langerhans islets as well lowered the sugar levels and stimulated insulin.
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Research funding: None declared.
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Author contributions: E.N and H.R conceived the research, analyzed the results, and wrote the manuscript. A.F. performed the computational work. All authors reviewed the manuscript.
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Competing interests: Authors state no conflict of interest.
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Ethical approval: The Research Animal Ethics Committee has approved the protocol for animal experimentation at Taif University, SA (Protocol number: 39-31-0034). We confirm that experiments were performed following relevant guidelines and regulations.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- N-acetyl-cysteine as adjuvant therapy in female infertility: a systematic review and meta-analysis
- Climate change and declining fertility rate in Malaysia: the possible connexions
- Original Articles
- Potential anti-toxic effect of d-ribose-l-cysteine supplement on the reproductive functions of male rats administered cyclophosphamide
- Environmental and climatic impact on the infection and mortality of SARS-CoV-2 in Peru
- Prophylactic intravenous paracetamol use in extremely premature infants for patent ductus arteriosus
- Evaluation of heart rate variability, blood pressure and lipid profile alterations from dual transceiver mobile phone radiation exposure
- Strain specific response of mice to IMQ-induced psoriasis
- Curcumin exerts hepatoprotection via overexpression of Paraoxonase-1 and its regulatory genes in rats undergone bile duct ligation
- Zinc oxide nanoparticles with green tea extract complex in the pancreas of rats against monosodium glutamate toxicity
- Phenolic constituents and inhibitory effects of the leaf of Rauvolfia vomitoria Afzel on free radicals, cholinergic and monoaminergic enzymes in rat’s brain in vitro
- Protective and curative role of vitamin D and hormones on the cadmium-induced inhibition of proliferation of human osteoblast cells
- The effect of bee pollen on reproductive and biochemical parameters in methotrexate-induced testicular damage in adult rats
- Histomorphometric study on effects of monosodium glutamate in liver tissue of Wistar rats
- Diligent profiling of preclinical safety of the silk protein sericin
Articles in the same Issue
- Frontmatter
- Reviews
- N-acetyl-cysteine as adjuvant therapy in female infertility: a systematic review and meta-analysis
- Climate change and declining fertility rate in Malaysia: the possible connexions
- Original Articles
- Potential anti-toxic effect of d-ribose-l-cysteine supplement on the reproductive functions of male rats administered cyclophosphamide
- Environmental and climatic impact on the infection and mortality of SARS-CoV-2 in Peru
- Prophylactic intravenous paracetamol use in extremely premature infants for patent ductus arteriosus
- Evaluation of heart rate variability, blood pressure and lipid profile alterations from dual transceiver mobile phone radiation exposure
- Strain specific response of mice to IMQ-induced psoriasis
- Curcumin exerts hepatoprotection via overexpression of Paraoxonase-1 and its regulatory genes in rats undergone bile duct ligation
- Zinc oxide nanoparticles with green tea extract complex in the pancreas of rats against monosodium glutamate toxicity
- Phenolic constituents and inhibitory effects of the leaf of Rauvolfia vomitoria Afzel on free radicals, cholinergic and monoaminergic enzymes in rat’s brain in vitro
- Protective and curative role of vitamin D and hormones on the cadmium-induced inhibition of proliferation of human osteoblast cells
- The effect of bee pollen on reproductive and biochemical parameters in methotrexate-induced testicular damage in adult rats
- Histomorphometric study on effects of monosodium glutamate in liver tissue of Wistar rats
- Diligent profiling of preclinical safety of the silk protein sericin
