Protective effect of Elateriospermum tapos in maternal obesity-induced deficit cognitive function of the offspring

Azrina Zainal Abidin; Nurain Syahirah Rosli; Santhra Segaran; Azmiza Syawani Jasni; Hasnah Bahari

doi:10.1515/jbcpp-2020-0053

Article

Protective effect of Elateriospermum tapos in maternal obesity-induced deficit cognitive function of the offspring

Azrina Zainal Abidin , Nurain Syahirah Rosli , Santhra Segaran , Azmiza Syawani Jasni and Hasnah Bahari

Published/Copyright: February 8, 2021

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From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 32 Issue 6

Abstract

Objectives

Pre-pregnancy obesity is a serious epidemics concern that negatively affects the neurodevelopmental of the offspring. Elateriospermum tapos (E. tapos) commonly used to enhance weight loss in obesity treatment. This study was aimed to investigate the influence of E. tapos supplement in obese maternal prior pregnancy on the offspring’s bodyweight, lipid metabolism and memory function.

Methods

Thirty female Sprague Dawley rats were used. Six rats were assigned to the normal diet group (DND). The remaining rats were fed with a high-fat and cafeteria diet (HFCD) to generate obesity for 5 weeks. Obese rats were further divided into four groups: Negative Control (DNC; HFCD), Positive Control (DPC; Orlistat 200 mg/kg), treatment 1 (DTX1; E. tapos seed 200 mg/kg) and treatment 2 (DTX2, E. tapos shell 200 mg/kg) were given daily, for 6 weeks prior to mating. At weaning, offspring of both genders were designated into six groups according to their dam’s group (n=6/group). All groups were fed with a cafeteria diet except for the control group. Memory tasks for object and place recognition were conducted on offspring at eighth weeks of age. The offspring were cull at the 12th week of age for their blood sample.

Results

Both offspring genders from DTX2 significantly reduce bodyweight, calorie intake and triglyceride level. In memory tasks, offspring from DTX2 showed a significant increase in exploration rate in place test as compared to offspring from the DNC group.

Conclusions

This study highlights E. tapos shell as an anti-obesity agent and protecting memory deficit in obese dam’s offspring.

Keywords: Elateriospermum tapos ; high-fat cafeteria diet; maternal obesity; memory deficit; offspring

Corresponding author: Hasnah Bahari, Department of Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia, E-mail: haba@upm.edu.my

Funding source: Fundamental Research Grants (FRGS)

Award Identifier / Grant number: FRGS/1/2016/SKK08/UPM/02/14 ( (04-01-16-1813FR)

Acknowledgments

The authors would like to acknowledge the Ministry of Higher Education (MoHE) Malaysia under Grant FRGS/1/2016/SKK08/UPM/02/14 (04-01-16-1813FR) for funding this project.

Research funding: Ministry of Higher Education (MoHE) Malaysia under Grant FRGS/1/2016/SKK08/UPM/02/14 (04-01-16-1813FR).
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Not applicable.
Ethical approval: The local Institutional Review Board deemed the study exempt from review.

References

1. Sanchez, CE, Barry, C, Sabhlok, A, Russell, K, Majors, A, Kollins, SH, et al.. Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis. Obes Rev 2017;19:464–48.https://doi.org/10.1111/obr.12643.Search in Google Scholar PubMed PubMed Central

2. Liang, J, Matheson, B, Kaye, W, Boutelle, K. Neurocognitive correlates of obesity and obesity-related behaviors in children and adolescents. Int J Obes 2014;38:494–506.https://doi.org/10.1038/ijo.2013.142.Search in Google Scholar PubMed PubMed Central

3. James, PT. Obesity: the worldwide epidemic. Clin Dermatol 2004;22:276–80.https://doi.org/10.1016/j.clindermatol.2004.01.010.Search in Google Scholar PubMed

4. Carol, LB, Khan, NA, Jim, MM, Raine, LB, Eric, SD, Moore, RD, et al.. Dietary lipids are differentially associated with hippocampal-dependent relational memory in prepubescent children. Am J Clin Nutr 2014;99:1026.https://doi.org/10.3945/ajcn.113.079624.Search in Google Scholar PubMed PubMed Central

5. Corner, EJH Wayside trees of Malaya, 3rd ed., Volume 2. Malaysia, Kuala Lumpur: Malaysian Nature Society; 1988.Search in Google Scholar

6. Chai, PPK, Lee, BMH, Othman, I. Native medicinal plants of Sarawak. Kuching: Forest Department; 1989.Search in Google Scholar

7. Yong, OY, Salimon, J. Characteristics of Elateriospermum tapos seed oil as a new source of oilseed. Ind Crop Prod 2006;24:146–51.https://doi.org/10.1016/j.indcrop.2006.03.001.Search in Google Scholar

8. Nor Liyana, J, Siroshini, KT, Nurul Syahirah, MB, Chang, WL, Nurul Husna, S, Daryl, JA, et al.. Phytochemical analysis of Elateriospermum tapos and its inhibitory effects on alpha-amylase, alpha-glucosidase and pancreatic lipase. J Trop Forest Sci 2019;31:240–8.https://doi.org/10.26525/jtfs2019.31.2.240248.Search in Google Scholar

9. Kokila, VP, Nor Liyana, J, Santhra, SB, Azrina, ZA, Daryl, JA, Nurul, HS, et al.. Preventive effect of Elateriospermum tapos seed extract against obese Sprague Dawley rats. Oriental Pharm Exp Med 2019. https://doi.org/10.1007/s13596-019-00394-w.Search in Google Scholar

10. Santhra, SB, Azrina, ZA, Kokila, VP, Amalia, HAL, Sharmmila, D, Malarmugila, M, et al.. Effect of elateriospermum tapos extract as coadjuvant in ameliorating maternal obesity on female offspring at weaning. Malaysian J Microsc 2019;15:111–28.Search in Google Scholar

11. Cheurfa, Allem. Study of hypocholesterolemic activity of Algerian Pistacia lentiscus leaves extracts in vivo. Rev Bras Farmacogn 2015;25:142–4.https://doi.org/10.1016/j.bjp.2015.02.011.Search in Google Scholar

12. Niloofar, H, Louse, T. High-fat deit-induced obesity in animal models. Nutr Res Rev 2010;23:270–99.10.1017/S0954422410000168Search in Google Scholar PubMed

13. Beilharz, JE, Maniam, J, Morris, MJ. Short-term exposure to a diet high in fat and sugar, or liquid sugar, selectively impairs hippocampal-dependent memory, with differential impacts on inflammation. Behav Brain Res 2016;306:1–7.https://doi.org/10.1016/j.bbr.2016.03.018.Search in Google Scholar PubMed

14. Baranowska, A, Skowron, B, Ciesielczyk, K, Domagala, J, Thor, PJ. Experimental gender related obesity effect of diet. Folio Medica Cracoviensia 2016;1:49–60.Search in Google Scholar

15. Sun, B, Liang, NC, Ewald, ER, Purcell, RH, Boersma, GJ, Yan, J, et al. Early postweaning exercise improves central leptin sensitivity in offspring of rat dams fed high-fat diet during pregnancy and lactation. Am J Physiol Regul Integr Comp Physiol 2013;305:1076–84.https://doi.org/10.1152/ajpregu.00566.2012.Search in Google Scholar PubMed PubMed Central

16. Chakrabarti, R. Pharmacotherapy of obesity: emerging drugs and targets. Expert Opin Ther Targets 2009;13:195–207.https://doi.org/10.1517/14728220802637063.Search in Google Scholar PubMed

17. Tao, NP, Wang, XC, Yao, H, Wu, WH. Effects of jade perch oil microcapsules on blood lipids and related indices. Acta Nutr Sin 2009;31:502–4.Search in Google Scholar

18. Desai, M, Jellyman, JK, Han, G, Beall, M, Lane, RH, Ross, MG. Rat maternal obesity and high fat diet programming offspring metabolic syndrome. Am J Obstet Gynecol 2014;211:237e1–3. http://www.who.int/en/.https://doi.org/10.1016/j.ajog.2014.03.025.Search in Google Scholar PubMed PubMed Central

19. Matsumoto, N, Okushio, K, Hara, Y. Effect of black tea polyphenols on plasma lipids in cholesterol-fed rats. J Nutr Sci Vitaminol 1998;44:337–42.https://doi.org/10.3177/jnsv.44.337.Search in Google Scholar PubMed

20. Beilharz, JE, Maniam, J, Morris, MJ. Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats. Brain Behav Immun 2014;37:134–41.https://doi.org/10.1016/j.bbi.2013.11.016.Search in Google Scholar PubMed

21. Buchenauer, T, Behrendt, P, Bode, FJ, Horn, R, Brabant, G, Stephan, M, et al.. Diet induced obesity alters behavior as well as serum levels of corticosterone in F344 rats. Physiol Behav 2009;98:563–9.https://doi.org/10.1016/j.physbeh.2009.09.003.Search in Google Scholar PubMed

22. Mitra, R, Sapolsky, RM. Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy. Proc Natl Acad Sci USA 2008;105:5573–8.https://doi.org/10.1073/pnas.0705615105.Search in Google Scholar PubMed PubMed Central

Received: 2020-03-08

Accepted: 2020-09-25

Published Online: 2021-02-08

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Articles in the same Issue

https://doi.org/10.1515/jbcpp-2020-0053

Keywords for this article

Elateriospermum tapos; high-fat cafeteria diet; maternal obesity; memory deficit; offspring