Enoxaparin induced reactive thrombocytosis: a rare adverse drug reaction
-
Saleel Salman Meenpidiyil
,
Shihas Azeez
Abstract
Objectives
Enoxaparin is a low molecular weight heparin (LMWH), which belongs to the class of anticoagulants. The drug is administered as subcutaneous injection to prevent or treat deep vein thrombosis (DVT), pulmonary embolism and ischemic complications.
Case Presentation
A 57-year-old women diagnosed with acute coronary syndrome developed reactive thrombocytosis following the administration of enoxaparin subcutaneously. The blood test reports of the patient showed that there is a gradual elevation of platelet count day by day following enoxaparin administration. On an assessment using both World Health Organization–Uppsala Monitoring Centre (WHO–UMC) scale and Naranjo Causality Assessment Scale indicated that enoxaparin is the “probable” cause for the reaction.
Conclusions
We conclude that reactive thrombocytosis is a probable adverse drug reaction and close monitoring of blood counts is essential, following enoxaparin injection. More studies are to be conducted to identify further complications.
Acknowledgments
The authors wish to express their deep gratitude to the entire dignitaries, who have been supportive in the successful completion of this work.
Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The ethical approval was deemed by the hospital ethics committee.
References
1. Tripathi, KD. Essentials of medical pharmacology, 7th ed. New Delhi: Jaypee Brothers Medical Publishers; 2013:619.10.5005/jp/books/12256Search in Google Scholar
2. Lepercq, J, Conard, J, Borel-Derlon, A, Darmon, JY, Boudignet, O, Francoual, C, et al. Venous thromboembolism during pregnancy: a retrospective study of enoxaparin safety in 624 pregnancies. An Int J Obstet Gynaecol 2001;108:1134140. https://doi.org/10.1111/j.1471-0528.2003.00272.x.Search in Google Scholar PubMed
3. Aydogan, T, Kanbay, M, Alici, O, Kosar, A. Incidence and etiology of thrombocytosis in an adult Turkish population. Platelets 2006;17:328–31. https://doi.org/10.1080/09537100600746573.Search in Google Scholar PubMed
4. Araneda, M, Krishnan, V, Hall, K, Kalbfleisch, J, Krishnaswamy, G, Krishnan, K. Reactive and clonal thrombocytosis: pro-inflammatory and hematopoietic cytokines and acute phase proteins. Southern medical journal 2001;94:417–20.10.1097/00007611-200194040-00012Search in Google Scholar
5. Santhosh-Kumar, CR, Yohannan, MD, Higgy, KE, Al-Mashhadani, SA. Thrombocytosis in adults: analysis of 777 patients. J Int Med 1991;229:493–5. https://doi.org/10.1111/j.1365-2796.1991.tb00383.Search in Google Scholar
6. Vo, QT, Thompson, DF. A review and assessment of drug induced thrombocytosis. Ann Pharmacother 2019;53:523–36. https://doi.org/10.1177/1060028018819450.Search in Google Scholar PubMed
7. Frye, JL, Thompson, DF. Drug-induced thrombocytosis. J Clin Pharm Ther 1993;18:45–8.10.1111/j.1365-2710.1993.tb00565.xSearch in Google Scholar PubMed
8. Hummel, MC, Morse, BC, Hayes, LE. Reactive thrombocytosis associated with enoxaparin. Pharmacotherapy 2006;26:1667–70. https://doi.org/10.1592/phco.26.11.1667.Search in Google Scholar PubMed
© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Review
- Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L. towards future medicine
- Original Articles
- Relationship between trough level of tyrosine kinase inhibitor (imatinib and nilotinib) and BCR-ABL ratios in an Indonesian chronic-phase chronic myeloid leukemia (CML) population
- Dietary supplementation of Pleurotus tuber regium in rat feed ameliorates metabolic and hematotoxicity induced by carbon tetrachloride
- Protective effects and chemical composition of Corchorus olitorius leaf fractions against isoproterenol-induced myocardial injury through p65NFkB-dependent anti-apoptotic pathway in rats
- Natural limonoids protect mice from alcohol-induced liver injury
- Production of the secondary metabolite catechin by in vitro cultures of Camellia sinensis L
- Modulatory properties of cardiac and quercetin glycosides from Dacryodes edulis seeds during L-NAME-induced vascular perturbation
- Case Report
- Enoxaparin induced reactive thrombocytosis: a rare adverse drug reaction
Articles in the same Issue
- Review
- Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L. towards future medicine
- Original Articles
- Relationship between trough level of tyrosine kinase inhibitor (imatinib and nilotinib) and BCR-ABL ratios in an Indonesian chronic-phase chronic myeloid leukemia (CML) population
- Dietary supplementation of Pleurotus tuber regium in rat feed ameliorates metabolic and hematotoxicity induced by carbon tetrachloride
- Protective effects and chemical composition of Corchorus olitorius leaf fractions against isoproterenol-induced myocardial injury through p65NFkB-dependent anti-apoptotic pathway in rats
- Natural limonoids protect mice from alcohol-induced liver injury
- Production of the secondary metabolite catechin by in vitro cultures of Camellia sinensis L
- Modulatory properties of cardiac and quercetin glycosides from Dacryodes edulis seeds during L-NAME-induced vascular perturbation
- Case Report
- Enoxaparin induced reactive thrombocytosis: a rare adverse drug reaction
